<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20908

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTHQNHQTNGASLEDCHTNFFALTDLCGIRWRQLVLGERPNAAGDPLDDPVVRSYSKCLAVDILCVWRRVVAPKPKPKPDPDPSSMFDMSIPGTGNSGSVVHPPLSLTAAKELWIFWYGEEPDLTDLVAPELLNSSEAGDKGSWENGLSYECRSLLFKALHNVIERCLLSRGFVRIEQWFVHPTSNDERVFGKSSHHASFSFTFFVHGDSTVITAMDIREHPPVRLLTMKHLEEAQRAAAPGAAAAAAAAASTTGGPASPDGGLNAAPGCAPGSPGGSSNSAVVPADDAIEPREVLLAPFAITGTLTGQSYRASDPHTQKILDDWSAFYPITNKHSGLADGADSMPPLVEVLVGKMKMRYPSKYVLVPDMDDWTSAGDARSNSSSSSSSSSNTNSNQTTTPATAAASIAASVLSRINSASERSGGGVASNSTTSSTINTTSNQTAGSSSSNAAAAAAASSARPKDTANDAAAPSPTGTLRQRNHHKSMMTPPLTVPESPSNDLGNPLSMSSALINKSPAVILPERVWQDCIMHASTPAATAASSSASSGTTATTTAPGSVTIKTEPKDNTSGSNSSTNNNNNNNSSSGGGDENSSGAANGVDANGNSSVWEISDPTVKVSCCCIKCCKRPPSSSSSSSSSSASSSASGRTQQQQQQQHTIGAAGSSAANATGGSNYTSISSPGGGGAAAAGGSGSLHPHPKSSYSITYPGSSSGSSRSSHYHHHQSTKDHHHHHHHHHHRPQRVAFHKRPPQEALFRPGTEPLSLSAAAALAAAAAAAAANAASSPGAVSSGDSAADSLELADTCLRSNQNCAANSGGGGGNSGASNMTGAAPGSTTPYGGPPSYCRNPMSIGDSHPLPSEGSPASAAPSPMQPSSVSQPTSVPSGDQLITMSPHPPASNNPRSVQPGTPCLDHLDKNTPAPTPTDQHDSKSINASPYHTPSHPGGGGGGGSSGGTTEGGQQQQAGANLMGNSSSSSSSNSSSNGSNSSSNSLGALKASPRSSLSSSGIGSLKVRSESSLGAGGSCSLGSGGGSGGGVPMTPSIHSVFSSAHQTAMANNLASKRESILQMLQSLKRPSLFCKDYETLQGEDIPSTSQLLYDYTCVDAWMNHPVKRMRLAAEENRLVKKIRNLDLYANEHSRTMASGPGLAGSGNSTNGIGTNGMLMKGAAEASEALAEALSGGRAGTGGASDNGAPNNGAGCTPLLGQIKMEIGCDGSQGGAAVGSANGGTPDRNGASAGNGGAGDGALLGEHEIKKEKEDKGSIFLTDQDLQPSIDDLNQIFDDGGPFNDDPDLHNTPPGSNKSSSGSGGFSEESKRFPSSNHHSVNSGMLSPKELSQMFPTPPSLDPQHPSSSPGGGGCLSDGGSIALDTLVDLQMSLSSGTGSGGGSGGGASSVPPIPNLGSPQEEPIDDWSFVFLPPPICPYVGSSKYAPLPSLPSQQVMPPIPTSTVAGLVYKSTRQKQKEQAAAEREKQKQREQAEREREREQKQEQQQQQDQPDGQPESGGQGGAGGGPGRAVGVAGPTTTSLGVGLGLLPIVKQEVGGLTVPQPLSTPNSLLGGLSGLNGGSLAHPYSNPPSQGAQSQPHSRPPSVNSLPGGIMGGGAGMLSPSPAGTSGGGLFHPGGMGGIPVPLRQGMSPISPATPGGSMRVPTPQGSCPLPYPSPLGGAGSPNPMGSLSFRRTTPLLPPPPYDVAIASPANSVATPSSYHSKQYPLDGVDSGGPGSNRGPMTPSSTGGSGPLGAGTVHPPLSSSGVGCGTGTPAGSRSIETNALLVNVLLYDTALNIFRDHNFKSCTLCVCNAGAKCVGNIRGADSGLYLALPGTNWMDSVTAAGAEPTPSTTPGPAGGRSKASALAHLGLGGSSSAFGAGMLGSPAVGRQEDKSAAVTINTDSLQNGYLDEDPIDCQCGFSAVVNRRMAHRAGLFYEDEMEITGMAEDPAVHKNGSLFEFLNGTAKAIKLEDADRGALATSAGGSSSTAAGGDSLPLTLKVMDLLREQCSVVQSSSNSIHRAVNRYRGPLFGRGAENGAVHLLEYVDANDVISLALEQGRLQAINESKMDVDQQQSSSGALVKGGTLRGQMNVHKWPFLRAGGPKSNQDIVRIMKSMQPLLQDAFHKRCTTRLWDAPYTIQGPLTWRQFHRLAGRGTGQCEPQPIPSLIVGYEKDWLSLAPYALHYWDKLLLEPYSYPRDVAYVAIVPDNDYVVAKVRTYFKELSTTYEMCKLGRHTPIKGWDGILRVGSQRVLKETQNSNLDEWFTNMGVDQQRKNGTTTTTAAGSTGSSSSGLNELLRLYAQTCQQQLAPYLSKVPSDKSLLDPPESHHHTSSSASASASLGGGAAGASSLGGGAMGQPGGNAMGQNRPDGPGQSPMPPPPPSTPDSSQPGDKAPNTPKFDHDSENRDQLNTSSASPADGMRIDDDGKDPPHIVLYIVEPFTCGNDSPDVERLACLSLLRCYSNILNAVPDSIRSNISVQIISLESILELGRNRNRLRLSDHMRCLALSVFSQSRKYLAHMNTVKSLTGFGTAANAEQFIKRKDDKNRVPYRLYTPPYVLARSCEKSENTESFGKTSMKQQCSIMYCSYCLSEDQSWLLAVATDDRGEFLETVTINIDIPNRGRRKRASARRYGLQKLMDFILGLISQTVQPWRLVVGRIGRIGHGELKGWSWLLSKPNLQRASKHLKDICEQCSLMHPIAVPSILSACLVTLEPDSDLRVMSDQFTPDERFSQRSMQSPLSTPQDATCTHILVFPTSAKAQSAQASFSVIGELDLGEDLNMVIMDGDDDDDGINMMDVFKCWDDLPMQQINMPHSRPGSPSQFEGNQQSPGESGSKGAGSRDGYGSQDSEEVGLVLQQPLAIGYLVSTAPTGRMPEWFWSSCPHMENVCPVFLRTALHLHSPTILQNTDDPLQQNQSSTEHPLDSNITADVLRYVLEGYNLLSWLAMDSNTHDRLSCLPIHVQVLMQLYHMTAALA
Length2971
PositionMiddle
OrganismAnopheles quadriannulatus (Mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.05
Grand average of hydropathy-0.445
Instability index53.16
Isoelectric point6.06
Molecular weight309918.46
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20908
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     138.00|      25|      28|    1609|    1633|       1
---------------------------------------------------------------------------
  940-  964 (31.09/ 7.14)	.TP.SHPGGGGGGG.SSGGTteGGQQQQ
 1378- 1399 (32.09/ 7.69)	MSL.SSGTGSGGGS..GGGA..SSVP.P
 1609- 1633 (41.53/12.83)	LSP.SPAGTSGGGLFHPGGM..GGIPVP
 1638- 1662 (33.29/ 8.34)	MSPiSPA.TPGGSMRVPTPQ..GSCPLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     134.47|      26|      26|     970|     995|       3
---------------------------------------------------------------------------
  377-  398 (32.94/ 9.17)	GDAR.....................SNSSSSSSSS.........SNTNSNQ...T
  605-  650 (30.04/ 7.54)	GNSSvweisdptvkvscccikcckrPPSSSSSSSSS........SASSSAS.GRT
  971-  995 (40.34/13.36)	GNSS.....................SSSSSNSSSNG........SNSSSNSLGA.
 1730- 1762 (31.16/ 8.17)	GPMT.....................PSSTGGSGPLGagtvhpplSS.SGVGCGTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.54|      20|      28|    1178|    1204|       4
---------------------------------------------------------------------------
 1182- 1219 (12.45/13.88)	GGraGTGGASdnGApNNGAGCTPllgqikmeigcDgsQ
 2346- 2365 (35.09/ 9.35)	GG..GAMGQP..GG.NAMGQNRP...........D..G
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     315.29|      36|      37|     831|     866|       5
---------------------------------------------------------------------------
  239-  267 (36.62/ 8.84)	AAPGAAA....A...AAA.......AAS.TT.........GGP..........ASPDGGLNAA
  521-  554 (32.28/ 6.70)	ILPERV.........WQD.......CIM.HA.........STPAATAA.S..SSASSGTTATT
  555-  596 (34.83/ 7.96)	TAPGSVTiktePkdnTSG.......SNS.ST.........NNNNNNNS.S..SGGGDENSSG.
  688-  718 (31.30/ 6.22)	AA.............AGG.......SGS.LH.........PHPKS..SySitYPGSSSGSSRS
  784-  826 (37.24/ 9.15)	SSPGAVS....S....GD.......SAA.DSleladtclrSNQ.NCAA.N..SGGGGGNSGAS
  831-  866 (61.95/21.34)	AAPGSTT....P...YGG.......PPS.YC.........RNPMSIGD.S..HPLPSEGSPAS
  998- 1037 (31.07/ 6.10)	ASPRSSL....S...SSGigslkvrSES.SL.........GAGGSCSL.G..SGGGSGGG...
 1572- 1607 (49.99/15.44)	AHPYSNP....P...SQG.......AQSqPH.........SRPPSVN..S..LPGGIMGGGAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     259.57|      57|     353|    1299|    1357|       6
---------------------------------------------------------------------------
  446-  504 (80.93/29.94)	GSSSSNAAAAAAASSARPKDTANDAAAPSptGTLRQRNhhKSMM..TPP.L....TVPES....PSNDLG
  882-  908 (32.41/ 7.18)	.........................SVPS..G....DQ..LITMSPHPPaS....NNPR......SVQPG
 1301- 1357 (106.73/48.27)	GSNKSSSGSGGFSEESKRFPSSNHHSVNS..GMLSPKE..LSQMFPTPP.S....LDPQH....PSSSPG
 1668- 1709 (39.51/10.81)	.........GGAGS...PNPM..........GSLSFRR..TTPLLPPPP.YdvaiASPANsvatPSS...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.90|      15|      21|    1404|    1423|       7
---------------------------------------------------------------------------
 1404- 1423 (25.27/21.91)	GSPQEEPIDDwsfvfLP.....PPI
 1428- 1447 (24.62/ 9.21)	GSSKYAPLPS.....LPsqqvmPPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     305.13|      99|     111|    1764|    1872|       9
---------------------------------------------------------------------------
 1764- 1872 (151.52/108.43)	PA.GSRSIETNALLVNVllyDTALNIFRDHNFKSCTlCvcnaGAKCVGNIRGAD.SGLY....LALPGTNWMDSVTAAGA..EPTPSTTPGPAGGRSKASALAhLGLGGSSSAfGAG
 1877- 1983 (153.61/83.18)	PAvGRQEDKSAAVTINT...DSLQNGYLDEDPIDCQ.C....GFSAVVNRRMAHrAGLFyedeMEITGMAEDPAVHKNGSlfEFLNGTAKAIKLEDADRGALA.TSAGGSSST.AAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.88|      17|      21|    1461|    1480|      10
---------------------------------------------------------------------------
 1461- 1480 (23.91/21.75)	RQKQKEQaaaEREKQKQREQ
 1483- 1499 (29.97/18.65)	REREREQ...KQEQQQQQDQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.71|      13|      21|    1261|    1273|      11
---------------------------------------------------------------------------
 1261- 1273 (23.61/13.86)	DKGSIFLTDQDLQ
 1284- 1296 (27.10/17.30)	DDGGPFNDDPDLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     172.36|      54|     525|    2392|    2452|      15
---------------------------------------------------------------------------
 2392- 2452 (85.93/64.87)	PKFDHDSENRDQLNTSSA.SPADGmRIDDDgkdpphIVLYIVEPFT....CGNDSPDVERLACLSL
 2897- 2955 (86.43/47.91)	PTILQNTDDPLQQNQSSTeHPLDS.NITAD......VLRYVLEGYNllswLAMDSNTHDRLSCLPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.72|      18|      28|     273|     290|      25
---------------------------------------------------------------------------
  273-  290 (31.21/16.04)	GSPGGSSNSAVVPADDAI
  304-  321 (32.51/17.09)	GTLTGQSYRASDPHTQKI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20908 with Med13 domain of Kingdom Metazoa
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