<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20907

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTHQNHQTNGASLEDCHTNFFALTDLCGIRWRQLVLGERPNAAGDPLDDPVVRSYSKCLAVDILCVWRRVVAPKPKPKPDPDPSSMFDMSIPGTGNSGSVVHPPLSLTAAKELWIFWYGEEPDLTDLVAPELLNSSEAGDKGSWENGLSYECRSLLFKALHNVIERCLLSRGFVRIEQWFVHPTSNDERVFGKSSHHASFSFTFFVHGDSTVITAMDIREHPPVRLLTMKHLEEAQRAAAPGAAAAAAAAASTTGGPASPDGGLNAAPGCAPGSPGGSSNSAVVPADDAIEPREVLLAPFAITGTLTGQSYRASDPHTQKILDDWSAFYPITNKHSGLADGADSMPPLVEVLVGKMKMRYPSKYVLVPDMDDWTSAGDARSNSSSSSSSSSNTNSNQTTTPATAAASIAASVLSRINSASERSGGGVASNSTTSSTINTTSNQTAGSSSSNAAAAAAASSARPKDTANDAAAPSPTGTLRQRNHHKSMMTPPLTVPESPSNDLGNPLSMSSALINKSPAVILPERVWQDCIMHASTPAATAASSSASSGTTATTTAPGSVTIKTEPKDNTSGSNSSTNNNNNNNSSSGGGDENSSGAANGVDANGNSSVWEISDPTVKVSCCCIKSNQNCAANSGGGGGNSGASNMTGAAPGSTTPYGGPPSYCRNPMSIGDSHPLPSEGSPASAAPSPMQPSSVSQPTSVPSGDQLITMSPHPPASNNPRSVQPGTPCLDHLDKNTPAPTPTDQHDSKSINASPYHTPSHPGGGGGGGSSGGTTEGGQQQQAGANLMGNSSSSSSSNSSSNGSNSSSNSLGALKASPRSSLSSSGIGSLKVRSESSLGAGGSCSLGSGGGSGGGVPMTPSIHSVFSSAHQTAMANNLASKRESILQMLQSLKRPSLFCKDYETLQGEDIPSTSQLLYDYTCVDAWMNHPVKRMRLAAEENRLVKKIRNLDLYANEHSRTMASGPGLAGSGNSTNGIGTNGMLMKGAAEASEALAEALSGGRAGTGGASDNGAPNNGAGCTPLLGQIKMEIGCDGSQGGAAVGSANGGTPDRNGASAGNGGAGDGALLGEHEIKKEKEDKGSIFLTDQDLQPSIDDLNQIFDDGGPFNDDPDLHNTPPGSNKSSSGSGGFSEESKRFPSSNHHSVNSGMLSPKELSQMFPTPPSLDPQHPSSSPGGGGCLSDGGSIALDTLVDLQMSLSSGTGSGGGSGGGASSVPPIPNLGSPQEEPIDDWSFVFLPPPICPYVGSSKYAPLPSLPSQQVMPPIPTSTVAGLVYKSTRQKQKEQAAAEREKQKQREQAEREREREQKQEQQQQQDQPDGQPESGGQGGAGGGPGRAVGVAGPTTTSLGVGLGLLPIVKQEVGGLTVPQPLSTPNSLLGGLSGLNGGSLAHPYSNPPSQGAQSQPHSRPPSVNSLPGGIMGGGAGMLSPSPAGTSGGGLFHPGGMGGIPVPLRQGMSPISPATPGGSMRVPTPQGSCPLPYPSPLGGAGSPNPMGSLSFRRTTPLLPPPPYDVAIASPANSVATPSSYHSKQYPLDGVDSGGPGSNRGPMTPSSTGGSGPLGAGTVHPPLSSSGVGCGTGTPAGSRSIETNALLVNVLLYDTALNIFRDHNFKSCTLCVCNAGAKCVGNIRGADSGLYLALPGTNWMDSVTAAGAEPTPSTTPGPAGGRSKASALAHLGLGGSSSAFGAGMLGSPAVGRQEDKSAAVTINTDSLQNGYLDEDPIDCQCGFSAVVNRRMAHRAGLFYEDEMEITGMAEDPAVHKNGSLFEFLNGTAKAIKLEDADRGALATSAGGSSSTAAGGDSLPLTLKVMDLLREQCSVVQSSSNSIHRAVNRYRGPLFGRGAENGAVHLLEYVDANDVISLALEQGRLQAINESKMDVDQQQSSSGALVKGGTLRGQMNVHKWPFLRAGGPKSNQDIVRIMKSMQPLLQDAFHKRCTTRLWDAPYTIQGPLTWRQFHRLAGRGTGQCEPQPIPSLIVGYEKDWLSLAPYALHYWDKLLLEPYSYPRDVAYVAIVPDNDYVVAKVRTYFKELSTTYEMCKLGRHTPIKGWDGILRVGSQRVLKETQNSNLDEWFTNMGVDQQRKNGTTTTTAAGSTGSSSSGLNELLRLYAQTCQQQLAPYLSKVPSDKSLLDPPESHHHTSSSASASASLGGGAAGASSLGGGAMGQPGGNAMGQNRPDGPGQSPMPPPPPSTPDSSQPGDKAPNTPKFDHDSENRDQLNTSSASPADGMRIDDDGKDPPHIVLYIVEPFTCGNDSPDVERLACLSLLRCYSNILNAVPDSIRSNISVQIISLESILELGRNRNRLRLSDHMRCLALSVFSQSRKYLAHMNTVKSLTGFGTAANAEQFIKRKDDKNRVPYRLYTPPYVLARSCEKSENTESFGKTSMKQQCSIMYCSYCLSEDQSWLLAVATDDRGEFLETVTINIDIPNRGRRKRASARRYGLQKLMDFILGLISQTVQPWRLVVGRIGRIGHGELKGWSWLLSKPNLQRASKHLKDICEQCSLMHPIAVPSILSACLVTLEPDSDLRVMSDQFTPDERFSQRSMQSPLSTPQDATCTHILVFPTSAKAQSAQASFSVIGELDLGEDLNMVIMDGDDDDDGINMMDVFKCWDDLPMQQINMPHSRPGSPSQFEGNQQSPGESGSKGAGSRDGYGSQDSEEVGLVLQQPLAIGYLVSTAPTGRMPEWFWSSCPHMENVCPVFLRTALHLHSPTILQNTDDPLQQNQSSTEHPLDSNITADVLRYVLEGYNLLSWLAMDSNTHDRLSCLPIHVQVLMQLYHMTAALA
Length2789
PositionMiddle
OrganismAnopheles quadriannulatus (Mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.05
Grand average of hydropathy-0.429
Instability index51.80
Isoelectric point5.80
Molecular weight291728.27
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP20907
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|    1352.32|     204|     204|     450|     653|       1
---------------------------------------------------------------------------
  245-  418 (160.95/41.23)	....................................AAAAAAASTtggpASPDGGLN........AApgC...APgS.PGGS....................SNSAV..VP.ADDAIE..PREVLLAPFAITGTLTGQSYRASDPhtQKIL..DD..WS..AF...YP.ITNK....H....SGLADG...A..DSMP......PLVEVLVG.KMK....MRY..........PSKYVLVPDMD..DWT.SAGD.ARSNSSSSSSS.SSNTNSN..QTTT...PaTAAA.SiAAS....VLSRIN.S
  419-  630 (305.81/85.36)	ASERSGGG...VASNSTTSSTINttsnqtagsssSNAAAAAAASS....ARPKDTAN........DA..A...AP.S.PTGTLRQRN..............HHKSMM..TP.PLTVPES.PSNDLGNPLSMSSALINKSPAVILP..ERVW..QDCIMH..AS...TPAATAA....S....SSASSGTTAT..TTAP......GSVTIKTE.PKD....NTS..........GSNSSTNNNNN..NNS.SSGG.GDENSSGAANGVDANGNSSVWEISD...P.TVKV.S.CCC....IKSNQN.C
  631-  844 (210.69/56.38)	AANSGGGGGNSGASNMTGAAPGSttpyggppsycRN.PMSIGDSH....PLPSEGSP........AS..A...AP.S.P..........................MQ..PS.SVSQPTSvPSGD..QLITMSP....HPPASNNP..RSVQpgTPCLDHldKN...TPAPTPTdqhdS....KSINASPYHT..PSHPggggggGSSGGTTEgGQQ....QQA..........GANLMGNSSSS..SSSnSSSN.GSNSSSNSLGALKASPRSSLSSSGI...G.SLKVrS.ESS....LGAGGS.C
  845- 1033 (221.37/59.64)	SLGSGGGSG..GGVPMT...................PSIHSVFSS....AHQTAMAN........NL..A......S.KRESILQ................MLQSLK..RP.SLFCKDY.ETLQ.GEDIPSTSQLLYDYTCV......DAW..MNHPVK..RM...RLAAEEN....R....LVKKIRNLDL..YANE......HSRTMASG.P......GLA..........GSGNSTNGIGT..NGM.LMKG.AAEASEALAEAL.SGGRAGTGGASDngaP.NNGA.G.CTPllgqIKMEIG.C
 1123- 1248 (104.50/24.04)	..................................SSSGSGGFSEE....SKRFPSSN........HH..S...VN.S...GMLSPKE..............LSQMFP..TP.PSLDPQH.PSSSPGGGGCLSD.....GGSIALD..TLV....DLQM....S...LSSGTGS....G....GGSGGGASSV..PPIP....nlGS..PQEE.PID....DWSfvflpppicpYVGSS.....................................................................
 1372- 1550 (170.90/44.26)	STPNSLLGGLSGLNGGSLAHP............ySNPPSQGAQSQ..phSRP.PSVNslpggimgGG..AgmlSP.S.PAGTSGGGL..............FHPGGMggIPvPLRQGMS.P.........ISPATPGGSMRVPTP..Q.....GSCPLP..YP...SPLGGAG....SpnpmGSLSFRRTTPllPPPP......YDVAIASP.A......NSV..........ATPSSYHSKQYplDGV.DSGGpG.............................................SNRGpM
 1551- 1728 (178.11/46.46)	TPSSTGGSGPLGAG..TVHPPLS....................SS....GVGCGTGT........PA..G...SR.SiETNAL....lvnvllydtalnifRDHNFK..SC.TLCVCNA.GAKCVGNIRGADSGLY.....LALP..GTNW..MDSVTA..AGaepTPSTT..........................P......GPAGGRSK.ASAlahlGLG..........GSSSAFGAGML..GSP.AVGR.QEDKSAAVTINTDSLQNGYLDE..D...P....I.D.CQC............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     434.16|     136|     431|    2042|    2298|       2
---------------------------------------------------------------------------
 2122- 2270 (212.23/163.67)	PYlSKvPSDKSLLDPPESHHHTSSSASASASLGGGAAGASSLgGGAMGQPggNAMG...QNRPDG..PG..QSPMPPPPPSTPDSSQPGDKApNTPKFDHDSENRDQLNTSSA.SPADGmRIDDDgkdpphIVLYIVEPFT....CGNDSPDVERLACLSL
 2626- 2773 (221.94/54.25)	PH.SR.PGSPSQFEGNQQSPGESGSKGAGSRDGYGSQDSEEV.GLVLQQP..LAIGylvSTAPTGrmPEwfWSSCPHMENVCPVFLRTALHL.HSPTILQNTDDPLQQNQSSTeHPLDS.NITAD......VLRYVLEGYNllswLAMDSNTHDRLSCLPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.88|      17|      21|    1279|    1298|       3
---------------------------------------------------------------------------
 1279- 1298 (23.91/24.20)	RQKQKEQaaaEREKQKQREQ
 1301- 1317 (29.97/20.75)	REREREQ...KQEQQQQQDQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.73|      13|      21|    1079|    1091|       4
---------------------------------------------------------------------------
 1079- 1091 (22.40/10.48)	DKGSIFLTDQDLQ
 1102- 1114 (25.33/12.85)	DDGGPFNDDPDLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.57|      24|     430|    2042|    2065|       5
---------------------------------------------------------------------------
 2042- 2065 (44.60/26.17)	KLGR..HTPIKGWDGIL.RVGSQRVLK
 2471- 2497 (36.96/20.30)	RIGRigHGELKGWSWLLsKPNLQRASK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.79|      13|     267|    1050|    1065|       6
---------------------------------------------------------------------------
 1037- 1058 (16.09/ 9.07)	QGGAAVGsanggtpdrNGASAG
 1327- 1339 (25.71/10.32)	QGGAGGG.........PGRAVG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20907 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAAAAAAAASTTGGPASPDGGLNAAPGCAPGSPGGSSNSAVVPADD
2) DDWTSAGDARSNSSSSSSSSSNTNSNQTTTPATAAASIAASVLSRINSASERSGGGVASNSTTSSTINTTSNQTAGSSSSNAAAAAAASSARPKDTANDAAAPSPTGTLRQRNHHKSMMTPPLTVPESPSNDLGNPLSMSSALINKSPA
3) ERVWQDCIMHASTPAATAASSSASSGTTATTTAPGSVTIKTEPKDNTSGSNSSTNNNNNNNSSSGGGDENSSGAANGVDANGNSSVW
4) GSQGGAAVGSANGGTPDRNGASAGNGGAGDGALLGEHEIKKEKEDKGSIFLTDQDLQPSIDDLNQIFDDGGPFNDDPDLHNTPPGSNKSSSGSGGFSEESKRFPSSNHHSVNSGMLSPKELSQMFPTPPSLDPQHPSSSPGGGGCLSDGGSI
5) GSSKYAPLPSLPSQQVMPPIPTSTVAGLVYKSTRQKQKEQAAAEREKQKQREQAEREREREQKQEQQQQQDQPDGQPESGGQGGAGGGPGRAVGVAGPTTT
6) KQEVGGLTVPQPLSTPNSLLGGLSGLNGGSLAHPYSNPPSQGAQSQPHSRPPSVNSLPGGIMGGGAGMLSPSPAGTSGGGLFHPGGMGGIPVPLRQGMSPISPATPGGSMRVPTPQGSCPLPYPSPLGGAGSPNPMGSLSFRRTTPLLPPPPYDVAIASPA
7) LAPYLSKVPSDKSLLDPPESHHHTSSSASASASLGGGAAGASSLGGGAMGQPGGNAMGQNRPDGPGQSPMPPPPPSTPDSSQPGDKAPNTPKFDHDSENRDQLNTSSASPADGMRIDDDGKD
8) LGAGGSCSLGSGGGSGGGVPMTPSIHSVFS
9) NSGGGGGNSGASNMTGAAPGSTTPYGGPPSYCRNPMSIGDSHPLPSEGSPASAAPSPMQPSSVSQPTSVPSGDQLITMSPHPPASNNPRSVQPGTPCLDHLDKNTPAPTPTDQHDSKSINASPYHTPSHPGGGGGGGSSGGTTEGGQQQQAGANLMGNSSSSSSSNSSSNGSNSSSNSLGALKASPRSSLSSSGIGSLKVRS
10) PSSYHSKQYPLDGVDSGGPGSNRGPMTPSSTGGSGPLGAGTVHPPLSSSGVGCGTGTP
11) QINMPHSRPGSPSQFEGNQQSPGESGSKGAGSRDGYGSQDSE
12) TLVDLQMSLSSGTGSGGGSGGGASSVPPIPNLGSPQEEPIDDWSF
13) WFTNMGVDQQRKNGTTTTTAAGSTGSSSSG
243
371
524
1035
1246
1359
2120
838
633
1525
2622
1190
2075
288
519
610
1186
1346
1519
2241
867
834
1582
2663
1234
2104










Molecular Recognition Features






MoRF SequenceStartStop




1) DWSFVFL
2) EQKQEQQQQQ
1231
1306
1237
1315