<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20907

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTHQNHQTNGASLEDCHTNFFALTDLCGIRWRQLVLGERPNAAGDPLDDPVVRSYSKCLAVDILCVWRRVVAPKPKPKPDPDPSSMFDMSIPGTGNSGSVVHPPLSLTAAKELWIFWYGEEPDLTDLVAPELLNSSEAGDKGSWENGLSYECRSLLFKALHNVIERCLLSRGFVRIEQWFVHPTSNDERVFGKSSHHASFSFTFFVHGDSTVITAMDIREHPPVRLLTMKHLEEAQRAAAPGAAAAAAAAASTTGGPASPDGGLNAAPGCAPGSPGGSSNSAVVPADDAIEPREVLLAPFAITGTLTGQSYRASDPHTQKILDDWSAFYPITNKHSGLADGADSMPPLVEVLVGKMKMRYPSKYVLVPDMDDWTSAGDARSNSSSSSSSSSNTNSNQTTTPATAAASIAASVLSRINSASERSGGGVASNSTTSSTINTTSNQTAGSSSSNAAAAAAASSARPKDTANDAAAPSPTGTLRQRNHHKSMMTPPLTVPESPSNDLGNPLSMSSALINKSPAVILPERVWQDCIMHASTPAATAASSSASSGTTATTTAPGSVTIKTEPKDNTSGSNSSTNNNNNNNSSSGGGDENSSGAANGVDANGNSSVWEISDPTVKVSCCCIKSNQNCAANSGGGGGNSGASNMTGAAPGSTTPYGGPPSYCRNPMSIGDSHPLPSEGSPASAAPSPMQPSSVSQPTSVPSGDQLITMSPHPPASNNPRSVQPGTPCLDHLDKNTPAPTPTDQHDSKSINASPYHTPSHPGGGGGGGSSGGTTEGGQQQQAGANLMGNSSSSSSSNSSSNGSNSSSNSLGALKASPRSSLSSSGIGSLKVRSESSLGAGGSCSLGSGGGSGGGVPMTPSIHSVFSSAHQTAMANNLASKRESILQMLQSLKRPSLFCKDYETLQGEDIPSTSQLLYDYTCVDAWMNHPVKRMRLAAEENRLVKKIRNLDLYANEHSRTMASGPGLAGSGNSTNGIGTNGMLMKGAAEASEALAEALSGGRAGTGGASDNGAPNNGAGCTPLLGQIKMEIGCDGSQGGAAVGSANGGTPDRNGASAGNGGAGDGALLGEHEIKKEKEDKGSIFLTDQDLQPSIDDLNQIFDDGGPFNDDPDLHNTPPGSNKSSSGSGGFSEESKRFPSSNHHSVNSGMLSPKELSQMFPTPPSLDPQHPSSSPGGGGCLSDGGSIALDTLVDLQMSLSSGTGSGGGSGGGASSVPPIPNLGSPQEEPIDDWSFVFLPPPICPYVGSSKYAPLPSLPSQQVMPPIPTSTVAGLVYKSTRQKQKEQAAAEREKQKQREQAEREREREQKQEQQQQQDQPDGQPESGGQGGAGGGPGRAVGVAGPTTTSLGVGLGLLPIVKQEVGGLTVPQPLSTPNSLLGGLSGLNGGSLAHPYSNPPSQGAQSQPHSRPPSVNSLPGGIMGGGAGMLSPSPAGTSGGGLFHPGGMGGIPVPLRQGMSPISPATPGGSMRVPTPQGSCPLPYPSPLGGAGSPNPMGSLSFRRTTPLLPPPPYDVAIASPANSVATPSSYHSKQYPLDGVDSGGPGSNRGPMTPSSTGGSGPLGAGTVHPPLSSSGVGCGTGTPAGSRSIETNALLVNVLLYDTALNIFRDHNFKSCTLCVCNAGAKCVGNIRGADSGLYLALPGTNWMDSVTAAGAEPTPSTTPGPAGGRSKASALAHLGLGGSSSAFGAGMLGSPAVGRQEDKSAAVTINTDSLQNGYLDEDPIDCQCGFSAVVNRRMAHRAGLFYEDEMEITGMAEDPAVHKNGSLFEFLNGTAKAIKLEDADRGALATSAGGSSSTAAGGDSLPLTLKVMDLLREQCSVVQSSSNSIHRAVNRYRGPLFGRGAENGAVHLLEYVDANDVISLALEQGRLQAINESKMDVDQQQSSSGALVKGGTLRGQMNVHKWPFLRAGGPKSNQDIVRIMKSMQPLLQDAFHKRCTTRLWDAPYTIQGPLTWRQFHRLAGRGTGQCEPQPIPSLIVGYEKDWLSLAPYALHYWDKLLLEPYSYPRDVAYVAIVPDNDYVVAKVRTYFKELSTTYEMCKLGRHTPIKGWDGILRVGSQRVLKETQNSNLDEWFTNMGVDQQRKNGTTTTTAAGSTGSSSSGLNELLRLYAQTCQQQLAPYLSKVPSDKSLLDPPESHHHTSSSASASASLGGGAAGASSLGGGAMGQPGGNAMGQNRPDGPGQSPMPPPPPSTPDSSQPGDKAPNTPKFDHDSENRDQLNTSSASPADGMRIDDDGKDPPHIVLYIVEPFTCGNDSPDVERLACLSLLRCYSNILNAVPDSIRSNISVQIISLESILELGRNRNRLRLSDHMRCLALSVFSQSRKYLAHMNTVKSLTGFGTAANAEQFIKRKDDKNRVPYRLYTPPYVLARSCEKSENTESFGKTSMKQQCSIMYCSYCLSEDQSWLLAVATDDRGEFLETVTINIDIPNRGRRKRASARRYGLQKLMDFILGLISQTVQPWRLVVGRIGRIGHGELKGWSWLLSKPNLQRASKHLKDICEQCSLMHPIAVPSILSACLVTLEPDSDLRVMSDQFTPDERFSQRSMQSPLSTPQDATCTHILVFPTSAKAQSAQASFSVIGELDLGEDLNMVIMDGDDDDDGINMMDVFKCWDDLPMQQINMPHSRPGSPSQFEGNQQSPGESGSKGAGSRDGYGSQDSEEVGLVLQQPLAIGYLVSTAPTGRMPEWFWSSCPHMENVCPVFLRTALHLHSPTILQNTDDPLQQNQSSTEHPLDSNITADVLRYVLEGYNLLSWLAMDSNTHDRLSCLPIHVQVLMQLYHMTAALA
Length2789
PositionMiddle
OrganismAnopheles quadriannulatus (Mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.05
Grand average of hydropathy-0.429
Instability index51.80
Isoelectric point5.80
Molecular weight291728.27
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20907
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|    1352.32|     204|     204|     450|     653|       1
---------------------------------------------------------------------------
  245-  418 (160.95/41.23)	....................................AAAAAAASTtggpASPDGGLN........AApgC...APgS.PGGS....................SNSAV..VP.ADDAIE..PREVLLAPFAITGTLTGQSYRASDPhtQKIL..DD..WS..AF...YP.ITNK....H....SGLADG...A..DSMP......PLVEVLVG.KMK....MRY..........PSKYVLVPDMD..DWT.SAGD.ARSNSSSSSSS.SSNTNSN..QTTT...PaTAAA.SiAAS....VLSRIN.S
  419-  630 (305.81/85.36)	ASERSGGG...VASNSTTSSTINttsnqtagsssSNAAAAAAASS....ARPKDTAN........DA..A...AP.S.PTGTLRQRN..............HHKSMM..TP.PLTVPES.PSNDLGNPLSMSSALINKSPAVILP..ERVW..QDCIMH..AS...TPAATAA....S....SSASSGTTAT..TTAP......GSVTIKTE.PKD....NTS..........GSNSSTNNNNN..NNS.SSGG.GDENSSGAANGVDANGNSSVWEISD...P.TVKV.S.CCC....IKSNQN.C
  631-  844 (210.69/56.38)	AANSGGGGGNSGASNMTGAAPGSttpyggppsycRN.PMSIGDSH....PLPSEGSP........AS..A...AP.S.P..........................MQ..PS.SVSQPTSvPSGD..QLITMSP....HPPASNNP..RSVQpgTPCLDHldKN...TPAPTPTdqhdS....KSINASPYHT..PSHPggggggGSSGGTTEgGQQ....QQA..........GANLMGNSSSS..SSSnSSSN.GSNSSSNSLGALKASPRSSLSSSGI...G.SLKVrS.ESS....LGAGGS.C
  845- 1033 (221.37/59.64)	SLGSGGGSG..GGVPMT...................PSIHSVFSS....AHQTAMAN........NL..A......S.KRESILQ................MLQSLK..RP.SLFCKDY.ETLQ.GEDIPSTSQLLYDYTCV......DAW..MNHPVK..RM...RLAAEEN....R....LVKKIRNLDL..YANE......HSRTMASG.P......GLA..........GSGNSTNGIGT..NGM.LMKG.AAEASEALAEAL.SGGRAGTGGASDngaP.NNGA.G.CTPllgqIKMEIG.C
 1123- 1248 (104.50/24.04)	..................................SSSGSGGFSEE....SKRFPSSN........HH..S...VN.S...GMLSPKE..............LSQMFP..TP.PSLDPQH.PSSSPGGGGCLSD.....GGSIALD..TLV....DLQM....S...LSSGTGS....G....GGSGGGASSV..PPIP....nlGS..PQEE.PID....DWSfvflpppicpYVGSS.....................................................................
 1372- 1550 (170.90/44.26)	STPNSLLGGLSGLNGGSLAHP............ySNPPSQGAQSQ..phSRP.PSVNslpggimgGG..AgmlSP.S.PAGTSGGGL..............FHPGGMggIPvPLRQGMS.P.........ISPATPGGSMRVPTP..Q.....GSCPLP..YP...SPLGGAG....SpnpmGSLSFRRTTPllPPPP......YDVAIASP.A......NSV..........ATPSSYHSKQYplDGV.DSGGpG.............................................SNRGpM
 1551- 1728 (178.11/46.46)	TPSSTGGSGPLGAG..TVHPPLS....................SS....GVGCGTGT........PA..G...SR.SiETNAL....lvnvllydtalnifRDHNFK..SC.TLCVCNA.GAKCVGNIRGADSGLY.....LALP..GTNW..MDSVTA..AGaepTPSTT..........................P......GPAGGRSK.ASAlahlGLG..........GSSSAFGAGML..GSP.AVGR.QEDKSAAVTINTDSLQNGYLDE..D...P....I.D.CQC............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     434.16|     136|     431|    2042|    2298|       2
---------------------------------------------------------------------------
 2122- 2270 (212.23/163.67)	PYlSKvPSDKSLLDPPESHHHTSSSASASASLGGGAAGASSLgGGAMGQPggNAMG...QNRPDG..PG..QSPMPPPPPSTPDSSQPGDKApNTPKFDHDSENRDQLNTSSA.SPADGmRIDDDgkdpphIVLYIVEPFT....CGNDSPDVERLACLSL
 2626- 2773 (221.94/54.25)	PH.SR.PGSPSQFEGNQQSPGESGSKGAGSRDGYGSQDSEEV.GLVLQQP..LAIGylvSTAPTGrmPEwfWSSCPHMENVCPVFLRTALHL.HSPTILQNTDDPLQQNQSSTeHPLDS.NITAD......VLRYVLEGYNllswLAMDSNTHDRLSCLPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.88|      17|      21|    1279|    1298|       3
---------------------------------------------------------------------------
 1279- 1298 (23.91/24.20)	RQKQKEQaaaEREKQKQREQ
 1301- 1317 (29.97/20.75)	REREREQ...KQEQQQQQDQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.73|      13|      21|    1079|    1091|       4
---------------------------------------------------------------------------
 1079- 1091 (22.40/10.48)	DKGSIFLTDQDLQ
 1102- 1114 (25.33/12.85)	DDGGPFNDDPDLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.57|      24|     430|    2042|    2065|       5
---------------------------------------------------------------------------
 2042- 2065 (44.60/26.17)	KLGR..HTPIKGWDGIL.RVGSQRVLK
 2471- 2497 (36.96/20.30)	RIGRigHGELKGWSWLLsKPNLQRASK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.79|      13|     267|    1050|    1065|       6
---------------------------------------------------------------------------
 1037- 1058 (16.09/ 9.07)	QGGAAVGsanggtpdrNGASAG
 1327- 1339 (25.71/10.32)	QGGAGGG.........PGRAVG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20907 with Med13 domain of Kingdom Metazoa
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