<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20905

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSIGDSHPLPSEGSPASAAPSPMQPSSVSQPTSVPSGDQLITMSPHPPASNNPRSVQPGTPCLDHLDKNTPAPTPTDQHDSKSINASPYHTPSHPGGGGGGGGGGGSSGGTTEGGQQQQASANLMGNSSSSSSSNSSSNGSNSSSNSSNSLSALKASPRSSLSSSGIGSLKVRSESSLGAGGSCSLGSGGGSGGGVPMTPSIHSVFSSAHQTALANNLASKRESILQMLQSLKRPSLFCKDYETLQGEDIPSTSQLLYDYTCVDAWMNHPVKRMRLAAEENRLVKKIRNLDLYANEHSRTMASGPGLAGSGNGTNGGIGTNGMLMKGAAEASEALAEALSGGRPGTGGGSDNGAPNNGAGCTPLLGQIKMEIGCDGSQAGTAVGSANGGTPDRNGASAGNGGAGDGALLGEHEIKKEKEDKGSIFLTDQDLQPSIDDLNQIFDDGGPFNDDPDLHNTPPGSNKSSSGSGGFSEESKRFPSSNHHSVNSGMLSPKELSQMFPTPPSLDPHPNSSPGGGGCLSDGGSIALDTLVDLQMSLSSGAGSGGNGGSGGTSSVPPIPNLGSPQEEPIDDWSFVFLPPPICPYVGSSKYAPLPSLPSQQVMPPIPTSTVAGLVYKSTRQKQKEQAAAEREKQKQREQAEREREREQKQEQQDQADGQPESGGQGGAGGGPGRPVGVAGPTTTALGVGLGLLPIVKQEVGGLTVPQPLSTPNSLLGGLSGLNGGSLAHPYSNPPSQGAQSQPHSRPPSVNSLPGGIMGSGAGMLSPSPAGTSGGGLFHPGGMGGIPVPLRQGMSPISPATPGGSMRVPTPQGSCPLPYPSPLGGAGSPNPMGSLNFRRTTPLLPPPPYDVAIASPANSVATPSSYHSKQYPLDGVDSGGPGSNRGPMTPSSTGGSGPLGAGTVNPPLSSSGVGCGTGTPAGSRSIETNALLVNVLLYDTALNIFRDHNFKSCTLCVCNAGAKCVGNIRGADSGLYLALPGTNWMDSVTAAGAEPTPSTTPGPAGGRSKASALAHLGLGGGGSSSAFGASMLGSPAVGRQEDKMAAVTINTDSLQNGYLDEDPIDCQCGFSAVVNRRMAHRAGLFYEDEMEITGMAEDPAVHKNGSLFEFLNGTAKAIKLEDADRGALATSAGGSSSAAGGDSLPLTLKVMDLLREQCSVVQSSSNSIHRAVNRYRGPLFGRGTENGAVHLLEYVDANDVISLALEQGRLQAINESKMDVDQQQQQQQQSSSGALVKGGTLRGQMNVHKWPFLRAGGPKSNQDIVRIMKSMQPLLQDAFHKRCTTRLWDAPYTIQGPLTWRQFHRLAGRGTGQCEPQPIPSLIVGYEKDWLSLAPYALHYWDKLLLEPYSYPRDVAYVAIVPDNDYVVAKVRTYFKELSTTYEMCKLGRHTPIKGWDGILRVGSQRVLKETQNSNLDEWFTNMGVDQQRKNGTTATAGSAGSSSSSSGLNELLRLYAQTCQQQLAPYLSKVPSDKSLLDPPESHHHTSSSASASASLGGGAAGASSLGGGSMGQPGGNAMGQNRPDGPGQSPMPPPPPSTPDSSQPGDKAPNTPKFDHDSENRDQLNTSSASPADGMRIDDDGKDPPHIVLYIVEPFTCGNDSPDVERLACLSLLRCYSNILNAVPDSIRSNISVQIISLESILELGRNRNRLRLSDHMRCLALSVFSQSRKYLAHMNTVKSLTGFGTAANAEQFIKRKDDKNRVPYRLYTPPYVLARSCEKSENTESFGKTSMKQQCSIMYCSYCLSEDQSWLLAVATDDRGEFLETVTINIDIPNRGRRKRASARRYGLQKLMDFILGLISQTVQPWRLVVGRIGRIGHGELKGWSWLLSKPNLQRASKHLKDICEQCSLMHPIAVPSILSACLVTLEPDSDLRVMSDQFTPDERFSQRSMQSPLSTPQDATCTHILVFPTSAKAQSAQASFSVIGELDLGEDLNMVIMDGDDDDDGINMMDVFKCWDDLPMQQINMPHSRPGSPSQFEGNQQSPGESGSKGAGSRDGYGSQDSEEVGLVLQQPLAIGYLVSTAPTGRMPEWFWSSCPHMENVCPVFLRTALHLHSPTILQNTDDPLQQNQSSTEHPLDSNITADVLRYVLEGYNLLSWLAMDSNTHDRLSCLPIHVQVLMQLYHMTAALA
Length2133
PositionMiddle
OrganismAnopheles merus (Mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.05
Grand average of hydropathy-0.453
Instability index54.57
Isoelectric point5.82
Molecular weight223869.14
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20905
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.27|      18|      24|     658|     681|       1
---------------------------------------------------------------------------
   93-  110 (34.72/ 9.02)	S..HPGGGGG.GGGGG...GSSGG
  658-  681 (20.55/14.09)	GqpESGGQGGaGGGPGrpvGVAGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     168.13|      25|      26|     557|     581|       2
---------------------------------------------------------------------------
  459-  482 (31.28/ 8.06)	PGSNKSSSGSGGFSEESK....RF.PSS..........N
  483-  504 (33.26/ 9.12)	HHSVN.SGMLSP.KELSQ....MF.PTP..........P
  558-  592 (34.15/ 9.60)	PIPNLGSPQEEPIDDWSF....VFLPPPicpyvgsskyA
  799-  821 (39.50/12.46)	PATPGGS.MRVPTPQGS.....CPLPYP..........S
  822-  847 (29.94/ 7.34)	PLGGAGS..PNPMGSLNFrrttPLLPPP...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     164.52|      24|      25|      24|      47|       3
---------------------------------------------------------------------------
    2-   22 (29.75/ 9.97)	...SIGDSHPLP..........SEGSP........ASA.APSP
   24-   47 (45.69/19.79)	QPSSVSQPTSVP..........SGDQL........ITM.SPHP
   52-   75 (38.45/15.33)	NPRSV.QP.GTP..........CLDHL......dkNTP.APTP
  705-  734 (24.02/ 6.44)	....VPQPLSTPnsllgglsglNGGSL........AHP.YSNP
  742-  769 (26.62/ 8.04)	QPHS..RP...P..........SVNSLpggimgsgAGMlSPSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     946.89|     299|     418|    1280|    1600|       6
---------------------------------------------------------------------------
 1280- 1600 (481.21/193.31)	HKRCTTRLWDAPYTIQGPLTWRQFHRLAGRGT..GQCEPqPIPSLIVGYEKDWLslAPYALHywDK.LLLEPYSYPRDVAYVA...IVPDNDYVVAKVRTYFKEL.STTYEMCKL..GR.....HTPIKGWDGIL.RVGSQRVLKETQnsNLDEWFTNMGvDQQRKNGTTATAGSAGSSSSSSGLNELLRLYAQTCQQQLAPYLSkVPSDKS...LLDPPESHHHTSSSASAS..ASLGGGAAGASSLGGGSMGQPGGNAMGQNRpdgpGQSPMPPPPPSTPdSSQPGdkAPNtpKFdhdsENRDQLNTSSASPADGMRIDDDGKDPPHIVLYIVEPFTCG
 1702- 2020 (465.68/154.21)	KNRVPYRLYTPPYVLARSCEKSENTESFGKTSmkQQCSI.MYCSYCLSEDQSWL..LAVATD..DRgEFLETVTINIDIPNRGrrkRASARRYGLQKLMDFILGLiSQTVQPWRLvvGRigrigHGELKGWSWLLsKPNLQRASKHLK..DICEQCSLMH.PIAVPSILSACLVTLEPDSDLRVMSDQFTPDERFSQRSMQSPLS.TPQDATcthILVFPTSAKAQSAQASFSviGELDLGEDLNMVIMDGDDDDDGINMMDVFK....CWDDLPMQQINMP.HSRPG..SPS..QF....EGNQQSPGESGSKGAGSRDGYGSQDSEEVGLVLQQPLAIG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      98.05|      18|      24|     152|     169|       7
---------------------------------------------------------------------------
  152-  169 (25.66/ 8.43)	SALKASPRSSLSSSGIGS
  176-  192 (25.57/ 8.36)	SSLGAGGSCSLGSGG.GS
  386-  402 (23.03/ 6.44)	ANGGTPDRNGA.SAGNGG
  884-  900 (23.79/ 7.01)	NRGPMTPSSTGGSGPLG.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.56|      26|      33|     960|     992|      11
---------------------------------------------------------------------------
  962-  992 (33.91/34.53)	AKCVgNIRGADSGlylALpGTNWMDSVTAAG
 1115- 1140 (44.65/19.16)	AKAI.KLEDADRG...AL.ATSAGGSSSAAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.53|      24|     416|     197|     223|      15
---------------------------------------------------------------------------
  197-  220 (40.63/26.48)	PMTPSIH..SVFSSAHQTALANNLAS
  227-  252 (36.90/16.14)	QMLQSLKrpSLFCKDYETLQGEDIPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.91|      22|     245|     771|     792|      17
---------------------------------------------------------------------------
  771-  792 (45.19/18.37)	GTSGGGLFHPGG..MGGIPVPLRQ
 1017- 1040 (36.71/13.43)	GLGGGGSSSAFGasMLGSPAVGRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.11|      20|     680|     256|     276|      19
---------------------------------------------------------------------------
  256-  276 (35.29/30.24)	LLYDyTCVDAWMNHPVKRMRL
  936-  955 (36.82/25.36)	LLYD.TALNIFRDHNFKSCTL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20905 with Med13 domain of Kingdom Metazoa
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