<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20904

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMNMRPLKRPRLGPPDVYPQEAKQREDELTSTHVKHGFATEHKLSEEFGTARNCNVSASKVGAYFNAILAKKEELMTLPDSGRKKQQINPKDNFWPVTARNKTTLDTWFKDLAGTKPLSSLAKKAPSFNKKEEIFAMLCENQVTMQRAAWFIKLSSAYTVAVSEAKIKKRQMPDPATEWTGTMIKFMKDLIPKLHEHYHQGPLQDKPSAGSAGSSSGMNSTNSGLGLGAGAGGTNPSTIPPPLSSPAGSMHSPAGGNPVGGSMHAQQQQQQQQPISPQEEQRIAQRQWNYSTQLCKYMYEEGLLDKQEFLNWIIDLLEKMKSSPNADDGLLRIYLPLAMQYLHDFVQSERFCRRLAYAVSKKLAQLINQMAESHNINLNSPDPDGNGKQSSNEMTDSKQEKQHDKPSKEGTNGTVSQSADVSPPKVNPYEMIFAEYLHCSHHRDVVLQLSSILQVITLECPTALVWCGVGETRSSSVLSGSPLDHLPVAPSALPMPARYEHSNEDIRRQLFEAEESIKVRSRHAESRWCIDKWQTAAGNASLKILATLDALDGHCFDRMDSNNSLDSLYSKIFPPFQVQPIKPSENSSGGSGNGQGSAAGGANTADGKDAATKQFEYNVEQDSSIVKILCEWAVSWQRWGEHRAMVVAWLLDKRQNEVLTALENDSYNNALNNSDDKDSVLSGSGLNGGQPVFQHILMNFLDHDAPVLEEGGSSQNKSQFTNLVHLFSELIRHDVFSHDAYMCCLISRGDLLTGAGGMLSLDSHGMCNAGLGTGPISNKPATSSSPNNGGGMEDDVLQTDFKAKLEDLDDSNVDDDLDKLLQHIKEDQQNSMDAPDSPKDPEHAAPSVTGLGKAESSSRHFLYTEHFPLCQDDPISQHDCNQRYILLYGVGKERDEKKHAVKKMSKEICKLFSKKFSIDVAEGGKVKKHSRSEFNFESTSNKCQAMSYFDQHVVTWQCAVQVQEMLNAFAVGNSNYLPVQEHVAFLFDLMESAFNIYGLIDTCIQILRELPEVELQLIGKSSLALVRSYTTSLSLYVVGVLRRYHCCLLLSQEQTTAIFEGLCRIVKHVSNPSDCSSAERCILAYLYDLYSACSSLKSRPQQEPFHNAYPKIKQALYTPLQPTPSAHTYNPQFMIEIITNPRRGGKIESAWARQLNESASNRYSFVCNAVVAVTRDIDNDCLNDIAAMCAELTACCNSLSTEWLGVLIALCGSNRDAGYYVDVLTQVDVQNTNIHNALSVFTSILVARHCFSLENFVAHVALPSLVQACKGRGETTPEIEAGARLSCHLLLRLFKTIECPQPGLYSVSTSPNPITVGNAHNIKLSCDRHLLAAAHKNIGVAPVLAVLKGILVVGDATAHKVSSIFGTGKRSGLNTPVHPGSTPKSMTGSGDLSHILGTSDLSILGNPDESMLDVSMIELEELSPTASARLYSSRQQNSHLNQENATSLSDFAQHVLRQICSQEWVLERCLQHAEELCQHGMLIDNLLTAKQAQRLLHMICYPEHESNLIAELDQKAIIVRILENLEQWSLRISWLDLQLMFKQTNCSSPDLSNWLDMVARAAIDVFRVNEFIMSNPDVKQEKVKPSTWLVAPLVSKLPSAVQGRILKVSGQVLESTSMFSKHKDGNGGNNSSNNNSHNHGANSNSSVSSNGSTFGSKQSSQLNHQPFLGLVLTCLKGQDEQKEGLLQSLYSQLSQFLQNRDQSLETIGGIEDPCGFEKMLDALQLRYSLVGGLFDAIMKNATSTTDWAILFAQLISQGVIDLSNNSELFTTTLDMLATLIHSTLVSDSQTERDENKKLYTNLMKKLRKELGDKNGPSIKYVRQLLPLAKQTCEVLTCDSAGSSTDAKGNKIAIDSIEKKNGLRLGDKQRVSVWDLLEGHKNPAPLSWAWFGAVKIERKPLAYEETHRLLKYHTHSLFKPSSYYYEPLPLPPEEVDPLPDKLKDDMKADTPSSDQSPAPSTGSKKSKTTRKRKPKATAAAQVQQSQPQQPIMPAIVPQTAAGPQQLQQMQQQQQQQQQQQQQQQMQQQQSLQQQQHLQQQQQQQLHLQQQQAQQQQHLQQQQQQQLQQLQQQQQQQLQQQQQQNQMMMQQQQQSNIPQQQQSALQQQQLGSQQPQQQQVAMTPQQTLQQMQNSNMGSMQMGGPMNTMNQQHMQQQYGQANPAQLVAQGNIGGMQTGMGGLGAGMGGSMMNQQQQQQQGPQQQQPQQAQQAQQAQQAQQQQQQQQSQGNPNMGFVGNVNPMAQLAQQQGGNQQWGGYGSMQQQHQQQQQQQQQQQQQQQGPQAQAQQQQQTPQQAQQASQQQGPQQGPQQGSQQGPQTQQQLQQQQQQQQMFYSGMGQATMTRFDRPQLNTNSKQALSNMLRSKLPINAGHPAGFMQPQQQQQQQQQQQQQQQQQQQQQQQQPQRNPQQQFMRGPLRTGMPGNPIVGAQAGMGPMNPAMAGGNAGIGATGGGAVMGAQAMAAGGMMGAGQGAQSQQTAGGIMNQNTPAMMGTTGGSIMGQSGGSMIQTSMMNPQQNPALVGQGMGSGGGIGGAGGMAGNSGMGGTAAGMGASGGGMVTSGGMVSAGMGSAGIGNAAPMGGGQSGMGGTSGMANAGGMGNPSMGNPGMGMQNMQQSGNMQGGMFQGQNVPYQNVNQNYPNYGNQGLGQQGGQGSGMMGNFNQMAQQQRTTQAEFLAQQRAAMVAGRGQYGQHAPNVTMGNMGVNQGAVPPYPRQGGKPGVGNMPQNQQQFQQQRMRLIMQQHSGMGQGSNAQGMMQNQGQGMSTQQTPNLVAQLQRQMPNQNNMMGQQYPHQPPQY
Length2792
PositionKinase
OrganismAnopheles funestus (African malaria mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.05
Grand average of hydropathy-0.631
Instability index55.00
Isoelectric point6.73
Molecular weight305918.26
Publications
PubMed=21129198
PubMed=31157884

Function

Annotated function 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats
>MDP20904
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|    1061.14|     120|     120|    2416|    2535|       1
---------------------------------------------------------------------------
 1975- 2033 (54.93/ 6.72)	.........................................................................TA.AAQ.....VQQSQPQ.............QPIMPaivpQTAaGPQQLQQMQQQQ.QQQQQQQQQQQ.MQQ.QQSLQQQQ....
 2035- 2100 (88.21/15.18)	..........................................LQQ......QQQ.QQLHL.QQQ..Q.AQQQQHL.QQQ......QQQQLQQL........QQQQQQQL....QQQ..QQ.QNQMMMQQ.QQQSNIPQQQQ.S...............
 2104- 2214 (142.21/28.90)	.........QQQLGSQQ...P..Q.......QQQVAMTPQQTLQQ......MQNSNMGSMqMGG.PMNTMNQQHM.QQQ.....YGQANPAQL....vaqGNIGGMQTG....MGGlGAGMGGSMMNQQ.QQQQQGPQQQQ.PQQAQQAQQAQQA...
 2223- 2334 (139.53/28.22)	SQGNPNMGF...VGNVN...PmaQLAqqqGGN...QQWGGYGSMQqqhqqqQQQQQQQQQ.QQQ.GPQAQAQQ............QQQTPQQAqqasqqqGPQQGPQQG....SQQ.GPQTQQQLQQQQ.QQQQMFYSGMG.................
 2335- 2417 (113.29/21.55)	.........QATMTRFD..rP..QL......NTNSKQALSNMLRS......KLPINAGHP.AGF.MQPQQQQQ............QQQQQQQQ.......QQ...........QQQ.....QQQQQQPQ.RNP....QQQF.MRGPL..RTGM.....
 2418- 2535 (195.18/42.36)	.PGNPIVGAQAGMGPMN...P..AMA...GGNAGIGATGGGAVMG......AQAMAAGGM.MGA.GQGAQSQQTA.GGI.....MNQNTPAMM.......GTTGGSIMG....QSG.GSMIQTSMMNPQ.QNPALVGQGMG.SGGGIGGAGGMAG...
 2537- 2618 (102.19/18.73)	..........SGMG...............GTAAGMGASGGG............MVTSGGM.VSA.GMG......S.AGIgnaapMGGGQSGMG.......GTSG...MA....NAG.G......MGNPSmGNP.....GMG.M.QNMQQSGNMQG..G
 2619- 2715 (119.40/23.10)	MFQGQNVPYQ....NVNqnyP..NY.....GNQGLGQQGG...............QGSGM.MGNfNQMAQQQRTTqAEF.....LAQQRAAMV.......AGRGQ..YG....Q................HAPNVTMGNMGvNQGAVPPYPRQGGkpG
 2719- 2790 (106.20/19.75)	MPQNQ...QQFQQQRMR...L..IM...........QQHSG..MG......QGSNAQGMM.QNQ.GQGMSTQQTP..NL.....VAQLQRQM.........PNQNNMMG....Q...........QYPH.QPP.........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.76|      18|      21|    1347|    1367|       2
---------------------------------------------------------------------------
 1348- 1367 (26.09/22.60)	GI.LVVGDATAHKvsSIFGTG
 1371- 1389 (27.67/11.81)	GLnTPVHPGSTPK..SMTGSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.63|      20|      25|    1731|    1754|       3
---------------------------------------------------------------------------
 1731- 1754 (25.70/31.09)	GLFDaIMKNA...TSTTDwaiLFAQLI
 1757- 1779 (28.93/17.89)	GVID.LSNNSelfTTTLD...MLATLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.64|      16|      16|    1457|    1472|       5
---------------------------------------------------------------------------
 1452- 1469 (25.41/14.78)	QHVlrQICSQEWVLERCL
 1470- 1486 (24.23/13.70)	QHA.eELCQHGMLIDNLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20904 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AGLGTGPISNKPATSSSPNNGGGMEDDVLQTDF
2) AQAMAAGGMMGAGQGAQSQQTAGGIMNQNTPAMMGTTGGSIMGQSGGSMIQTSMMNPQQNPALVGQGMG
3) DLDKLLQHIKEDQQNSMDAPDSPKDPEHAAPSVTGL
4) GIGNAAPMGGGQSGMGGTSGMANAGGMGNPSMGNPGMGMQNMQQSGNMQGGMFQGQNVP
5) HEHYHQGPLQDKPSAGSAGSSSGMNSTNSGLGLGAGAGGTNPSTIPPPLSSPAGSMHSPAGGNPVGGSMHAQQQQQQQQPISPQEEQRI
6) HNINLNSPDPDGNGKQSSNEMTDSKQEKQHDKPSKEGTNGTVSQSADV
7) LPLPPEEVDPLPDKLKDDMKADTPSSDQSPAPSTGSKKSKTTRKRKPKATAAAQVQQSQPQQPIMPAIVPQTAAGPQQLQQMQQQQQQQQQQQQQQQMQQQQSLQQQQHLQQQQQQQLHLQQQQAQQ
8) MNMRPLKRPRLGPPDVYPQEAKQREDELTSTHVKH
9) QNQMMMQQQQQSNIPQQQQSALQQQQLGSQQPQQQQVAMTPQQTLQQMQNSNMGSMQMGGPMNTMNQQHMQQQYGQANPAQLVAQGNIGGMQTGMGGLGAGMGGSMMNQQQQQQQGPQQQQPQQAQQAQQAQQAQQQQQQQQSQGNPNMGFVGNVNPMAQLAQQQGGNQQWGGYGSMQQQHQQQQQQQQQQQQQQQGPQAQAQQQQQTPQQAQQASQQQGPQQGPQQGSQQGPQTQQQLQQQQQQQQMFYSGMGQATMTRFDRPQLNTNSKQALSNMLRSKLPINAGHPAGFMQPQQQQQQQQQQQQQQQQQQQQQQQQPQRNPQQQFMRGPLRTGMPGNPIVGAQAGMGPMNPAMAGGNAGIGATGGGA
10) QNVNQNYPNYGNQGLGQQGGQGSGMMGNFNQMAQQQRTTQAEFLAQQRAAMVAGRGQYGQHAPNVTMGNMGVNQGAVPPYPRQGGKPGVGNMPQNQQQFQQQRMRLIMQQHSGMGQGSNAQGMMQNQGQGMSTQQTPNLVAQLQRQMPNQNNMMGQQYPHQPPQY
11) SMFSKHKDGNGGNNSSNNNSHNHGANSNSSVSSNGSTFGS
768
2454
815
2568
194
373
1926
1
2081
2628
1616
800
2522
850
2626
282
420
2052
35
2450
2792
1655










Molecular Recognition Features






MoRF SequenceStartStop




1) IMPAI
2) KPKATAAAQVQ
3) MNMRPLKRPRLG
4) MRLIM
1989
1971
1
2731
1993
1981
12
2735