<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20903

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTHQNHQTNGASLEDCHTNFFALTDLCGIRWRQLVLGERPNAAGDPLDDPVVRSYSKCLAVDILCVWRRVVAPKPKPKPEPDPSNMFDMSIPGTGNSGSVVHPPLSLTAAKELWIFWYGEEPDLTDLVAPELLNSSETGDKGSWENGLSYECRSLLFKALHNVIERCLLSRGFVRIGRWFVHPSSNSEGVFGKSSHHASFSFTFFVHGDSTVCTSMDIREHPPVRLLTMRHLEQAQQAQQAAPSAGPNGGPGSPSAAGVNGGGSINPGSPGGTAAAGNGGAANASATIASTDASEPREVILAPFGLAGTLTGQSYKASDPHVQKMLDDWSAFYPISNKLSGMEDGSDNVPPMVEILVGKLKMRYPTKYVLVADMDDWTSANDTRSNSSSNSNNSTSSNNSSSNQTATPVTAIPSIAASVLSRANNASERSSGPINATSNQPAAGNISSNSSNPPTARNKDTPNESSSVALSPTGTLRQRNHHKSMMTPPLTVPESPSNDLGNPLSMSSALINKSPAVILPERVWQDCIMHASPSPSPMSSSSANGSTSAASNGSQTISTTPGSGVTIKTEPKDTGSSSSGSTSNTATSSGGGDENSSGAANGVDANGNSSVWEISDPTVKVSCCCIKSNQNCATNSNSGSGGTNSTGAAAGSTTPYGGPPSYCRNPMSIGESHPLPSEGSPASAAPSPMQPSSVSQPTSVPSGDQLITMSPHPPASNNPRSVQPGTPCLDHLDKNTPAPTPTDQHDSKSINASPYHTPSHPGGGGGGGSTGSSGNGNSTEAQQQQQQSQSNSNMGNSSSSSSSGSNSSSNSSSLNALKTSPRSGTLSSGIGSLKVRSESSLGAGSSIGSGGGVPMTPSIHSVYSSAHQTAMANNLASKRESILQMLQSLKRPSLFCKDYETLQSEDIPSTSQLLYDYTCVDAWMNHPVKRMRLAMEENRLVKKIRNLDLYANEHSRTMTTSFGVSGAGMPGSNSVANAVGANGMLMKGVATGDSSDTLAETLGSHNGGGGGGGGGVGACDNGTSNNGSCQPLLGHGQIKMELGCDGSGAGRDGAGTGVAGSGMGGANGTPDRNGPSSGNGDGALLGEHEIKKEKEEKGSNFLTDQDLQPSIDDLNQIFDDGGPFNDDSDLHNTPPGSNKSCSGSGGFSEEGKRFPSSNHHSVNSGMLSPKELSQMFPTPPSIDPHPNSSPGGGGCLSDGGIAIDTLVDLQMSLSSGAGSGPGSGSNLPNLGSPQEEPIDDWSFVFLPPPICPYVGSSKYAPLPSLPSQLIIPQIPTSTCTSLVYKSTRQKQKEQAAAEREKQKLREQAERDREQQQQLQQDQQQNSQSDNNNASSTGASGTTSGIGGIGGSAGGLGLGLLPIIKQELGNLTIPQPLSTPNSLLGGLNNLNGSINHPYSNPPSQGAQSQPHSRPPSVNSLPGGIIGSGAGMLSPSPAGASGGLFHPGMGGIPVPLRQGMSPISPATPGGSMRVPTPQGGSCPLPYPSPLGGAAAGSPNPMGSLNFRRTTPLLPPPPYDVAIASPANSVATPSSYHSKQFPLDGVDNSGGPGSNRGPMTPSSTGGGPLGSTVNQPLSSTGGGVGCGTGVGTNGTSGGRSTNIETNALLVNILLYDTALNIFRDHNFKSCTLCVCNAGTKCVGNIRGADSGLYLALPGTNWMDSVTAPAETAAGSGTSGNGGVTGGRSKASALAHLGLSGGSSSSAFGGMLGSPAIGSSSDKTITINTDSLQNGYLDEDPIDCQCGFSAVVNRRMAHRAGLFYEDEMEITGMAEDPAVHKKSSLFEFLNGTAKAIKMEESGSGGSNGTLVATGGASATGGNGSDSLPLTLKVMDLLREQCSVVQSSSNSIHRAVNRYRGALFGRGLESGAVHLLEYVDANDVISLALEQGRLQAINESKMEVDQQQQSSSGSSSSSSSNVACSALVKGGTLRGIMNVHKWPFLRAGGPKSNQDIVRIMKSMQPLLQDAFHKRCTTRLWDAPYTIQGPLTWRQFHRLAGRGTGQCEPQPIPSLIVGYEKDWLSLAPYALHYWDKLLLEPYSYPRDVAYVAIVPDNDYVVAKVRTYFKELSTTYEMCKLGRHTPIKGWDGILRVGSQRVLKETQNSNLDEWFTNMGVDQQRKNGSSSSSGLNELLRLYAQTCQQQLAPYLSKVPSDKSLLDPPESHHHASSSSSSSASVSGGASGSSSLSGGSMNQPGGNSMGQNRGDGPGQSPMPPPPPSTPDSSQPGDKAPNTPKFDHDSENRDQLNTSSASPADGMRIDDDGKDPPHIVLYIVEPFTCGSDSPDVERLACLSLLRCYSNILNAVPDSIRSNISVQIISLESILELGRNRNRLRLSDHMRCLALSVFSQSRKYLAHMNTVKSLTGFGTAANAEQFIKRKDDKNRVPYRLYTPPYVLARSCEKSENTESFGKTSMKQQCSIMYCSYCLSEDQSWLLAVATDDRGEFLETVTINIDIPNRGRRKRASARRYGLQKLMDFILGLISQTVQPWRLVVGRIGRIGHGELKGWSWLLSKPNLQRASKHLKDICEQCSLMHPIAVPSILSACLVTLEPDSDLRVMSDQFTPDERFSQRSMQSPLSTPQDATCTHILVFPTSAKAQSAQASFSVIGELDLGEDLNMVIMDGDDDDDGINMMDVFKCWDDLPMQQINMPHSRPGSPSQFEGNQQSPGESGSKGAGSRDGYGSQDSEEVGLVLQQPLAIGYLVSTAPTGRMPEWFWSSCPHMENVCPVFLRTALHLHSPTILQNTDDPLQQNQSSTEHPLDSNITADVLRYVLEGYNLLSWLAMDSNTHDRLSCLPIHVQVLMQLYHMTAALA
Length2810
PositionMiddle
OrganismAnopheles funestus (African malaria mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.05
Grand average of hydropathy-0.459
Instability index53.50
Isoelectric point5.85
Molecular weight294987.20
Publications
PubMed=21129198
PubMed=31157884

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20903
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            12|    1051.18|     118|     248|     714|     831|       1
---------------------------------------------------------------------------
  234-  335 (81.34/16.81)	..............................................................................QA.......QQA..Q..QAA.....PSAGPNG.GPGSPSAAG.V.....................N...GGGS..IN..P.G.SP..GGT....AAAGNG.....................................gaanasatiasTDA...........S.....EPRE.....VilAP...........FGLAGTLT...G.Q..SYKA.....................SDPHVQ.KMLD..DwSA......FYPI
  336-  493 (90.46/19.54)	SNKLS..G....MEDG..SdnvppmveilVGKlkmryptkyvlvAD.MDDWT..........................SA.......NDT..R..SNS.....SSNSN...NSTSSNNSS.SnqtatpvtaipsiaasvlsraNNASERSSgpINATS.N.QP.AAGN....ISSNSS..............................................npPTA...........R.....N............K...........DTPNESSS...V.A..LSPTGT.................L.RQRNHH.KSMM..T.PP......LTVP
  494-  586 (87.75/18.73)	ESPSN..D....LGNP..L..........SMS............SA.LINKS..........................PAvilpervWQDciM..HAS.....PSPSPM....SSSSANG.S.....................TSAASNGS...QTIS.T.TP.GSG.................................................................................................................vtI.K..TEPKDT.................G.SSSSGS.TS...............NTA
  587-  758 (131.27/31.77)	TSSGG..G.denSSGA..A..........NGV............DA.NGNSS........................vwEI.......SDP..T..VKVsccciKSNQNCA.TNSNSGSGG.T.....................NSTGAA......AGS.T.TP.YGGP....PSYCRNpmsigeshplpsegspasaapspmqpssvsqptsvpsgdqlitmsphpPAS...........N.....NPRS.....V..QP...........GTPCLDHL...D.K..NTPAPT.................P.TDQHDS.KSIN..A.SP......YHTP
  759-  831 (109.23/25.16)	SHPGG..G....GGGG..S..........TGS............SG.NGNST..........................EA.......QQQ..Q..QQS.....QSNSNMG.NSSSSSSSG.S.....................NSSSNSSS..LNALK.T.SP.RSGT....LSSGIG.................................................................................................................................................................
 1006- 1179 (98.15/21.84)	.NGGG..G....GGGG..G..........VGA............CD.NGTSN..........................NG.......SCQ..PllGHG.....QIKMELGcDGSGAGRDG.A.....................GTGVAGSG..MGGAN.G.TPdRNGP.....SSGNG................................dgallgeheikkekeeKGS...........N...flTDQD.....L..QPsiddlnqifddGGPFNDDS...DlH..NTPPGSnkscsgsggfseegkrfP.SSNHHSvNSGM..L.SPkelsqmFPTP
 1184- 1275 (107.46/24.64)	PHPNS..S....PGGG..G..........CLS............DG..GIAI..........................DT.......LVD..L..QMS.....LS.........SGAGSG.P.....................GSGSN.....LPNL....................G...........................................spqeePID...........D.....WSFV.....F..LP...........PPIC.PYV...G.S..SKYAPL.................P.S..LPS.QLI.....IP.......QIP
 1276- 1417 (68.93/13.09)	T.................S..........TCT............SL.VYKSTrqkqkeqaaaerekqklreqaerdreQQ.......QQL..Q..QDQ.....QQNSQSD.NNNASSTGA.S............................................GT.....TSGIG...................giggsagglglgllpiikqelgnltipqpLST..................PNS.....L..LG...........G...LNNL...N.GsiNHPYSN.................P.PSQGAQ.SQPH..S.RP......PSVN
 1418- 1536 (83.11/17.34)	SLPGGiiG....SGAGmlS..........PSP............AGaSGGLF..........................H...........................PGMG.GIPVPLRQG.M.....................SPISPATP..GGSMR.VpTP.QGGScplpYPSPLG.......................................gaaagspnpMGS...........L.....NFRR.....T..TP...........LLP.................PP.................P.YDVAIA.SPANsvA.TP....ssYHSK
 1537- 1669 (76.91/15.48)	QFPLD..GvdnsGGPG..S.....nrgpmTPS............ST.GGGPL..........................GS.......TVN..Q..PLS.....STGGGVG.CGTGVGTNGtS.....................GGRSTNIE..TNAL........................................................................lvnillydtalNifrdhNFKSctlcvC..NA...........GTKCVGNIrgaD.S..GLYLAL.................PgTNWMD...SVT..A..P......AETA
 1670- 1733 (46.43/ 6.35)	AGSGT..S....GNGG..V..........TGG............RS.KA.SA..........................LA.......HLG..L..SGG.....SSSSAFG.GMLGSPAIG.S......................SSDKTIT..INT...D.SL.QNGY....L......................................................................................................................................................................
 2167- 2231 (70.15/13.46)	................................................................................................................SSSSSASV.S.....................GGASGSSS..LSGGSmN.QP.GGNS....MGQNRG..............................................dgPG............Q........S.........P...........MPP.................PP.................P.STP.DS.SQPG..D.KA......PNTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.71|      47|     500|    2238|    2291|       2
---------------------------------------------------------------------------
 2238- 2291 (73.47/55.66)	ENRD...QLNTSSA.SPADGmRIDDDgkdpphIVLYIVEPFTCGS....DSPDVERLACLSL
 2740- 2794 (70.24/36.60)	QNTDdplQQNQSSTeHPLDS.NITAD......VLRYVLEGYNLLSwlamDSNTHDRLSCLPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     185.82|      59|     500|    1980|    2052|       3
---------------------------------------------------------------------------
 1980- 2052 (94.03/87.62)	TIQgPltWRQFHRLAGR.GTGQCEpqpipslivGYekDWLSLAP....YALHYWDKL....LLEPYSYPR..DVAYVAIVPDND
 2482- 2551 (91.78/53.68)	TVQ.P..WRLVVGRIGRiGHGELK.........GW..SWLLSKPnlqrASKHLKDICeqcsLMHPIAVPSilSACLVTLEPDSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.22|      14|      15|     886|     899|       8
---------------------------------------------------------------------------
  886-  899 (27.05/18.33)	LQSLKRPSL..FCKDY
  902-  917 (21.17/12.39)	LQSEDIPSTsqLLYDY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20903 with Med13 domain of Kingdom Metazoa
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