<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20903

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTHQNHQTNGASLEDCHTNFFALTDLCGIRWRQLVLGERPNAAGDPLDDPVVRSYSKCLAVDILCVWRRVVAPKPKPKPEPDPSNMFDMSIPGTGNSGSVVHPPLSLTAAKELWIFWYGEEPDLTDLVAPELLNSSETGDKGSWENGLSYECRSLLFKALHNVIERCLLSRGFVRIGRWFVHPSSNSEGVFGKSSHHASFSFTFFVHGDSTVCTSMDIREHPPVRLLTMRHLEQAQQAQQAAPSAGPNGGPGSPSAAGVNGGGSINPGSPGGTAAAGNGGAANASATIASTDASEPREVILAPFGLAGTLTGQSYKASDPHVQKMLDDWSAFYPISNKLSGMEDGSDNVPPMVEILVGKLKMRYPTKYVLVADMDDWTSANDTRSNSSSNSNNSTSSNNSSSNQTATPVTAIPSIAASVLSRANNASERSSGPINATSNQPAAGNISSNSSNPPTARNKDTPNESSSVALSPTGTLRQRNHHKSMMTPPLTVPESPSNDLGNPLSMSSALINKSPAVILPERVWQDCIMHASPSPSPMSSSSANGSTSAASNGSQTISTTPGSGVTIKTEPKDTGSSSSGSTSNTATSSGGGDENSSGAANGVDANGNSSVWEISDPTVKVSCCCIKSNQNCATNSNSGSGGTNSTGAAAGSTTPYGGPPSYCRNPMSIGESHPLPSEGSPASAAPSPMQPSSVSQPTSVPSGDQLITMSPHPPASNNPRSVQPGTPCLDHLDKNTPAPTPTDQHDSKSINASPYHTPSHPGGGGGGGSTGSSGNGNSTEAQQQQQQSQSNSNMGNSSSSSSSGSNSSSNSSSLNALKTSPRSGTLSSGIGSLKVRSESSLGAGSSIGSGGGVPMTPSIHSVYSSAHQTAMANNLASKRESILQMLQSLKRPSLFCKDYETLQSEDIPSTSQLLYDYTCVDAWMNHPVKRMRLAMEENRLVKKIRNLDLYANEHSRTMTTSFGVSGAGMPGSNSVANAVGANGMLMKGVATGDSSDTLAETLGSHNGGGGGGGGGVGACDNGTSNNGSCQPLLGHGQIKMELGCDGSGAGRDGAGTGVAGSGMGGANGTPDRNGPSSGNGDGALLGEHEIKKEKEEKGSNFLTDQDLQPSIDDLNQIFDDGGPFNDDSDLHNTPPGSNKSCSGSGGFSEEGKRFPSSNHHSVNSGMLSPKELSQMFPTPPSIDPHPNSSPGGGGCLSDGGIAIDTLVDLQMSLSSGAGSGPGSGSNLPNLGSPQEEPIDDWSFVFLPPPICPYVGSSKYAPLPSLPSQLIIPQIPTSTCTSLVYKSTRQKQKEQAAAEREKQKLREQAERDREQQQQLQQDQQQNSQSDNNNASSTGASGTTSGIGGIGGSAGGLGLGLLPIIKQELGNLTIPQPLSTPNSLLGGLNNLNGSINHPYSNPPSQGAQSQPHSRPPSVNSLPGGIIGSGAGMLSPSPAGASGGLFHPGMGGIPVPLRQGMSPISPATPGGSMRVPTPQGGSCPLPYPSPLGGAAAGSPNPMGSLNFRRTTPLLPPPPYDVAIASPANSVATPSSYHSKQFPLDGVDNSGGPGSNRGPMTPSSTGGGPLGSTVNQPLSSTGGGVGCGTGVGTNGTSGGRSTNIETNALLVNILLYDTALNIFRDHNFKSCTLCVCNAGTKCVGNIRGADSGLYLALPGTNWMDSVTAPAETAAGSGTSGNGGVTGGRSKASALAHLGLSGGSSSSAFGGMLGSPAIGSSSDKTITINTDSLQNGYLDEDPIDCQCGFSAVVNRRMAHRAGLFYEDEMEITGMAEDPAVHKKSSLFEFLNGTAKAIKMEESGSGGSNGTLVATGGASATGGNGSDSLPLTLKVMDLLREQCSVVQSSSNSIHRAVNRYRGALFGRGLESGAVHLLEYVDANDVISLALEQGRLQAINESKMEVDQQQQSSSGSSSSSSSNVACSALVKGGTLRGIMNVHKWPFLRAGGPKSNQDIVRIMKSMQPLLQDAFHKRCTTRLWDAPYTIQGPLTWRQFHRLAGRGTGQCEPQPIPSLIVGYEKDWLSLAPYALHYWDKLLLEPYSYPRDVAYVAIVPDNDYVVAKVRTYFKELSTTYEMCKLGRHTPIKGWDGILRVGSQRVLKETQNSNLDEWFTNMGVDQQRKNGSSSSSGLNELLRLYAQTCQQQLAPYLSKVPSDKSLLDPPESHHHASSSSSSSASVSGGASGSSSLSGGSMNQPGGNSMGQNRGDGPGQSPMPPPPPSTPDSSQPGDKAPNTPKFDHDSENRDQLNTSSASPADGMRIDDDGKDPPHIVLYIVEPFTCGSDSPDVERLACLSLLRCYSNILNAVPDSIRSNISVQIISLESILELGRNRNRLRLSDHMRCLALSVFSQSRKYLAHMNTVKSLTGFGTAANAEQFIKRKDDKNRVPYRLYTPPYVLARSCEKSENTESFGKTSMKQQCSIMYCSYCLSEDQSWLLAVATDDRGEFLETVTINIDIPNRGRRKRASARRYGLQKLMDFILGLISQTVQPWRLVVGRIGRIGHGELKGWSWLLSKPNLQRASKHLKDICEQCSLMHPIAVPSILSACLVTLEPDSDLRVMSDQFTPDERFSQRSMQSPLSTPQDATCTHILVFPTSAKAQSAQASFSVIGELDLGEDLNMVIMDGDDDDDGINMMDVFKCWDDLPMQQINMPHSRPGSPSQFEGNQQSPGESGSKGAGSRDGYGSQDSEEVGLVLQQPLAIGYLVSTAPTGRMPEWFWSSCPHMENVCPVFLRTALHLHSPTILQNTDDPLQQNQSSTEHPLDSNITADVLRYVLEGYNLLSWLAMDSNTHDRLSCLPIHVQVLMQLYHMTAALA
Length2810
PositionMiddle
OrganismAnopheles funestus (African malaria mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.05
Grand average of hydropathy-0.459
Instability index53.50
Isoelectric point5.85
Molecular weight294987.20
Publications
PubMed=21129198
PubMed=31157884

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP20903
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            12|    1051.18|     118|     248|     714|     831|       1
---------------------------------------------------------------------------
  234-  335 (81.34/16.81)	..............................................................................QA.......QQA..Q..QAA.....PSAGPNG.GPGSPSAAG.V.....................N...GGGS..IN..P.G.SP..GGT....AAAGNG.....................................gaanasatiasTDA...........S.....EPRE.....VilAP...........FGLAGTLT...G.Q..SYKA.....................SDPHVQ.KMLD..DwSA......FYPI
  336-  493 (90.46/19.54)	SNKLS..G....MEDG..SdnvppmveilVGKlkmryptkyvlvAD.MDDWT..........................SA.......NDT..R..SNS.....SSNSN...NSTSSNNSS.SnqtatpvtaipsiaasvlsraNNASERSSgpINATS.N.QP.AAGN....ISSNSS..............................................npPTA...........R.....N............K...........DTPNESSS...V.A..LSPTGT.................L.RQRNHH.KSMM..T.PP......LTVP
  494-  586 (87.75/18.73)	ESPSN..D....LGNP..L..........SMS............SA.LINKS..........................PAvilpervWQDciM..HAS.....PSPSPM....SSSSANG.S.....................TSAASNGS...QTIS.T.TP.GSG.................................................................................................................vtI.K..TEPKDT.................G.SSSSGS.TS...............NTA
  587-  758 (131.27/31.77)	TSSGG..G.denSSGA..A..........NGV............DA.NGNSS........................vwEI.......SDP..T..VKVsccciKSNQNCA.TNSNSGSGG.T.....................NSTGAA......AGS.T.TP.YGGP....PSYCRNpmsigeshplpsegspasaapspmqpssvsqptsvpsgdqlitmsphpPAS...........N.....NPRS.....V..QP...........GTPCLDHL...D.K..NTPAPT.................P.TDQHDS.KSIN..A.SP......YHTP
  759-  831 (109.23/25.16)	SHPGG..G....GGGG..S..........TGS............SG.NGNST..........................EA.......QQQ..Q..QQS.....QSNSNMG.NSSSSSSSG.S.....................NSSSNSSS..LNALK.T.SP.RSGT....LSSGIG.................................................................................................................................................................
 1006- 1179 (98.15/21.84)	.NGGG..G....GGGG..G..........VGA............CD.NGTSN..........................NG.......SCQ..PllGHG.....QIKMELGcDGSGAGRDG.A.....................GTGVAGSG..MGGAN.G.TPdRNGP.....SSGNG................................dgallgeheikkekeeKGS...........N...flTDQD.....L..QPsiddlnqifddGGPFNDDS...DlH..NTPPGSnkscsgsggfseegkrfP.SSNHHSvNSGM..L.SPkelsqmFPTP
 1184- 1275 (107.46/24.64)	PHPNS..S....PGGG..G..........CLS............DG..GIAI..........................DT.......LVD..L..QMS.....LS.........SGAGSG.P.....................GSGSN.....LPNL....................G...........................................spqeePID...........D.....WSFV.....F..LP...........PPIC.PYV...G.S..SKYAPL.................P.S..LPS.QLI.....IP.......QIP
 1276- 1417 (68.93/13.09)	T.................S..........TCT............SL.VYKSTrqkqkeqaaaerekqklreqaerdreQQ.......QQL..Q..QDQ.....QQNSQSD.NNNASSTGA.S............................................GT.....TSGIG...................giggsagglglgllpiikqelgnltipqpLST..................PNS.....L..LG...........G...LNNL...N.GsiNHPYSN.................P.PSQGAQ.SQPH..S.RP......PSVN
 1418- 1536 (83.11/17.34)	SLPGGiiG....SGAGmlS..........PSP............AGaSGGLF..........................H...........................PGMG.GIPVPLRQG.M.....................SPISPATP..GGSMR.VpTP.QGGScplpYPSPLG.......................................gaaagspnpMGS...........L.....NFRR.....T..TP...........LLP.................PP.................P.YDVAIA.SPANsvA.TP....ssYHSK
 1537- 1669 (76.91/15.48)	QFPLD..GvdnsGGPG..S.....nrgpmTPS............ST.GGGPL..........................GS.......TVN..Q..PLS.....STGGGVG.CGTGVGTNGtS.....................GGRSTNIE..TNAL........................................................................lvnillydtalNifrdhNFKSctlcvC..NA...........GTKCVGNIrgaD.S..GLYLAL.................PgTNWMD...SVT..A..P......AETA
 1670- 1733 (46.43/ 6.35)	AGSGT..S....GNGG..V..........TGG............RS.KA.SA..........................LA.......HLG..L..SGG.....SSSSAFG.GMLGSPAIG.S......................SSDKTIT..INT...D.SL.QNGY....L......................................................................................................................................................................
 2167- 2231 (70.15/13.46)	................................................................................................................SSSSSASV.S.....................GGASGSSS..LSGGSmN.QP.GGNS....MGQNRG..............................................dgPG............Q........S.........P...........MPP.................PP.................P.STP.DS.SQPG..D.KA......PNTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.71|      47|     500|    2238|    2291|       2
---------------------------------------------------------------------------
 2238- 2291 (73.47/55.66)	ENRD...QLNTSSA.SPADGmRIDDDgkdpphIVLYIVEPFTCGS....DSPDVERLACLSL
 2740- 2794 (70.24/36.60)	QNTDdplQQNQSSTeHPLDS.NITAD......VLRYVLEGYNLLSwlamDSNTHDRLSCLPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     185.82|      59|     500|    1980|    2052|       3
---------------------------------------------------------------------------
 1980- 2052 (94.03/87.62)	TIQgPltWRQFHRLAGR.GTGQCEpqpipslivGYekDWLSLAP....YALHYWDKL....LLEPYSYPR..DVAYVAIVPDND
 2482- 2551 (91.78/53.68)	TVQ.P..WRLVVGRIGRiGHGELK.........GW..SWLLSKPnlqrASKHLKDICeqcsLMHPIAVPSilSACLVTLEPDSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.22|      14|      15|     886|     899|       8
---------------------------------------------------------------------------
  886-  899 (27.05/18.33)	LQSLKRPSL..FCKDY
  902-  917 (21.17/12.39)	LQSEDIPSTsqLLYDY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20903 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DDWTSANDTRSNSSSNSNNSTSSNNSSSNQTATPVTAIPSIAASVLSRANNASERSSGPINATSNQPAAGNISSNSSNPPTARNKDTPNESSSVALSPTGTLRQRNHHKSMMTPPLTVPESPSNDLGNPLSMSSALINKSPA
2) ERVWQDCIMHASPSPSPMSSSSANGSTSAASNGSQTISTTPGSGVTIKTEPKDTGSSSSGSTSNTATSSGGGDENSSGAANGVDANGNSSVW
3) GNLTIPQPLSTPNSLLGGLNNLNGSINHPYSNPPSQGAQSQPHSRPPSVNSLPGGIIGSGAGML
4) LAPYLSKVPSDKSLLDPPESHHHASSSSSSSASVSGGASGSSSLSGGSMNQPGGNSMGQNRGDGPGQSPMPPPPPSTPDSSQPGDKAPNTPKFDHDSENRDQLNTSSASPADGMRIDDDGKD
5) MELGCDGSGAGRDGAGTGVAGSGMGGANGTPDRNGPSSGNGDGALLGEHEIKKEKEEKGSNFLTDQDLQPSIDDLNQIFDDGGPFNDDSDLHNTPPGSNKSCSGSGGFSEEGKRFPSSNHHSVNSGMLSPKELSQMFPTPPSIDPHPNSSPGGGGCLS
6) NSNSGSGGTNSTGAAAGSTTPYGGPPSYCRNPMSIGESHPLPSEGSPASAAPSPMQPSSVSQPTSVPSGDQLITMSPHPPASNNPRSVQPGTPCLDHLDKNTPAPTPTDQHDSKSINASPYHTPSHPGGGGGGGSTGSSGNGNSTEAQQQQQQSQSNSNMGNSSSSSSSGSNSSSNSSSLNALKTSPRSGTLSSGIGSLKVRSESSLGAGSSIGSGGGVPMTPSIHSVYSSAHQTAM
7) PSSYHSKQFPLDGVDNSGGPGSNRGPMTPSSTGGGPLGSTVNQPLS
8) QINMPHSRPGSPSQFEGNQQSPGESGSKGAGSRDGYGSQDSE
9) SLVYKSTRQKQKEQAAAEREKQKLREQAERDREQQQQLQQDQQQNSQSDNNNASSTGASGTTSGIGGI
10) SPAGASGGLFHPGMGGIPVPLRQGMSPISPATPGGSMRVPTPQGGSCPLPYPSPLGGAAAGSPNPMGSLNFRRTTPLLPPPPYDVAIASPANSVA
11) VATGDSSDTLAETLGSHNGGGGGGGGGVGACDNGTSNNGSCQPLLGHG
12) VDLQMSLSSGAGSGPGSGSNLPNLGSPQEEPID
13) VRLLTMRHLEQAQQAQQAAPSAGPNGGPGSPSAAGVNGGGSINPGSPGGTAAAGNGGAANASATIASTDAS
375
521
1368
2141
1040
635
1530
2643
1281
1434
989
1207
224
516
612
1431
2262
1197
871
1575
2684
1348
1528
1036
1239
294










Molecular Recognition Features






MoRF SequenceStartStop




NANANA