<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20902

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTHQNHQTNGASLEDCHTNFFALTDLCGIRWRQLVLGERPNAAGDPLDDPVVRSYSKCLAVDILCVWRRVVAPKPKPKPEPDPSNMFDMSIPGTGNSGSVVHPPLSLTAAKELWIFWYGEEPDLTDLVAPELLNSSETGDKGSWENGLSYECRSLLFKALHNVIERCLLSRGFVRIGRWFVHPSSNSEGVFGKSSHHASFSFTFFVHGDSTVCTSMDIREHPPVRLLTMRHLEQAQQAQQAAPSAGPNGGPGSPSAAGVNGGGSINPGSPGGTAAAGNGGAANASATIASTDASEPREVILAPFGLAGTLTGQSYKASDPHVQKMLDDWSAFYPISNKLSGMEDGSDNVPPMVEILVGKLKMRYPTKYVLVADMDDWTSANDTRSNSSSNSNNSTSSNNSSSNQTATPVTAIPSIAASVLSRANNASERSSGPINATSNQPAAGNISSNSSNPPTARNKDTPNESSSVALSPTGTLRQRNHHKSMMTPPLTVPESPSNDLGNPLSMSSALINKSPAVILPERVWQDCIMHASPSPSPMSSSSANGSTSAASNGSQTISTTPGSGVTIKTEPKDTGSSSSGSTSNTATSSGGGDENSSGAANGVDANGNSSVWEISDPTVKVSCCCIKCCKRPPSSSSSTSTSSSSASSTASGRVSQHQQQQQQHTIGAAVSSSCSLSTTGSLANLYTSNPSPKSSYSITYPGTGGGGGGSNRGEKSTHGHQYHHYHHHHGGGGQSIKDHHHHHHHHHRPQRIAFHKRPPQEALFRPGTKPMSLSAAAAALAAAVAAAAGSSSTAANAAATSPGAVSSGDSAADSLELADSCLRSNQNCATNSNSGSGGTNSTGAAAGSTTPYGGPPSYCRNPMSIGESHPLPSEGSPASAAPSPMQPSSVSQPTSVPSGDQLITMSPHPPASNNPRSVQPGTPCLDHLDKNTPAPTPTDQHDSKSINASPYHTPSHPGGGGGGGSTGSSGNGNSTEAQQQQQQSQSNSNMGNSSSSSSSGSNSSSNSSSLNALKTSPRSGTLSSGIGSLKVRSESSLGAGSSIGSGGGVPMTPSIHSVYSSAHQTAMANNLASKRESILQMLQSLKRPSLFCKDYETLQSEDIPSTSQLLYDYTCVDAWMNHPVKRMRLAMEENRLVKKIRNLDLYANEHSRTMTTSFGVSGAGMPGSNSVANAVGANGMLMKGVATGDSSDTLAETLGSHNGGGGGGGGGVGACDNGTSNNGSCQPLLGHGQIKMELGCDGSGAGRDGAGTGVAGSGMGGANGTPDRNGPSSGNGDGALLGEHEIKKEKEEKGSNFLTDQDLQPSIDDLNQIFDDGGPFNDDSDLHNTPPGSNKSCSGSGGFSEEGKRFPSSNHHSVNSGMLSPKELSQMFPTPPSIDPHPNSSPGGGGCLSDGGIAIDTLVDLQMSLSSGAGSGPGSGSNLPNLGSPQEEPIDDWSFVFLPPPICPYVGSSKYAPLPSLPSQLIIPQIPTSTCTSLVYKSTRQKQKEQAAAEREKQKLREQAERDREQQQQLQQDQQQNSQSDNNNASSTGASGTTSGIGGIGGSAGGLGLGLLPIIKQELGNLTIPQPLSTPNSLLGGLNNLNGSINHPYSNPPSQGAQSQPHSRPPSVNSLPGGIIGSGAGMLSPSPAGASGGLFHPGMGGIPVPLRQGMSPISPATPGGSMRVPTPQGGSCPLPYPSPLGGAAAGSPNPMGSLNFRRTTPLLPPPPYDVAIASPANSVATPSSYHSKQFPLDGVDNSGGPGSNRGPMTPSSTGGGPLGSTVNQPLSSTGGGVGCGTGVGTNGTSGGRSTNIETNALLVNILLYDTALNIFRDHNFKSCTLCVCNAGTKCVGNIRGADSGLYLALPGTNWMDSVTAPAETAAGSGTSGNGGVTGGRSKASALAHLGLSGGSSSSAFGGMLGSPAIGSSSDKTITINTDSLQNGYLDEDPIDCQCGFSAVVNRRMAHRAGLFYEDEMEITGMAEDPAVHKKSSLFEFLNGTAKAIKMEESGSGGSNGTLVATGGASATGGNGSDSLPLTLKVMDLLREQCSVVQSSSNSIHRAVNRYRGALFGRGLESGAVHLLEYVDANDVISLALEQGRLQAINESKMEVDQQQQSSSGSSSSSSSNVACSALVKGGTLRGIMNVHKWPFLRAGGPKSNQDIVRIMKSMQPLLQDAFHKRCTTRLWDAPYTIQGPLTWRQFHRLAGRGTGQCEPQPIPSLIVGYEKDWLSLAPYALHYWDKLLLEPYSYPRDVAYVAIVPDNDYVVAKVRTYFKELSTTYEMCKLGRHTPIKGWDGILRVGSQRVLKETQNSNLDEWFTNMGVDQQRKNGSSSSSGLNELLRLYAQTCQQQLAPYLSKVPSDKSLLDPPESHHHASSSSSSSASVSGGASGSSSLSGGSMNQPGGNSMGQNRGDGPGQSPMPPPPPSTPDSSQPGDKAPNTPKFDHDSENRDQLNTSSASPADGMRIDDDGKDPPHIVLYIVEPFTCGSDSPDVERLACLSLLRCYSNILNAVPDSIRSNISVQIISLESILELGRNRNRLRLSDHMRCLALSVFSQSRKYLAHMNTVKSLTGFGTAANAEQFIKRKDDKNRVPYRLYTPPYVLARSCEKSENTESFGKTSMKQQCSIMYCSYCLSEDQSWLLAVATDDRGEFLETVTINIDIPNRGRRKRASARRYGLQKLMDFILGLISQTVQPWRLVVGRIGRIGHGELKGWSWLLSKPNLQRASKHLKDICEQCSLMHPIAVPSILSACLVTLEPDSDLRVMSDQFTPDERFSQRSMQSPLSTPQDATCTHILVFPTSAKAQSAQASFSVIGELDLGEDLNMVIMDGDDDDDGINMMDVFKCWDDLPMQQINMPHSRPGSPSQFEGNQQSPGESGSKGAGSRDGYGSQDSEEVGLVLQQPLAIGYLVSTAPTGRMPEWFWSSCPHMENVCPVFLRTALHLHSPTILQNTDDPLQQNQSSTEHPLDSNITADVLRYVLEGYNLLSWLAMDSNTHDRLSCLPIHVQVLMQLYHMTAALA
Length3006
PositionMiddle
OrganismAnopheles funestus (African malaria mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.05
Grand average of hydropathy-0.474
Instability index54.30
Isoelectric point6.16
Molecular weight314893.42
Publications
PubMed=21129198
PubMed=31157884

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20902
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.61|      17|      18|     713|     729|       2
---------------------------------------------------------------------------
  713-  729 (37.92/25.19)	GEKSTHGHQYHHYHHHH
  732-  748 (37.69/24.98)	GGQSIKDHHHHHHHHHR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            12|     687.05|      80|     252|     631|     710|       3
---------------------------------------------------------------------------
  471-  560 (66.39/14.61)	SPT...................................GT.L....RQRN............................................hhksmmTP...P...lTVPES...PSN.DLGNP..LSMSSALINKSpavilPERVWQD....CIMHASP....SP..SPMSS.............S.S..ANGSTSAASN....GSQTI..STT
  561-  629 (49.22/ 8.58)	PGS...................................G......................................................vtiktepKD...T....GSSSS...GST.SNTAT..SSGGGDENSSG.....AANGVDA....NGNSSVW....EI..SDPTV..........K.VS.C..CCIKCC..................
  631-  700 (96.65/25.23)	....................................................................................................RP...P....SSSSS...TST.SSSSA..SSTASGRVSQH.....QQQQQQH....TIGAAVS....SS..CSLST..........T.GS.L..ANLYTSNPSP....KSSYS..ITY
  765-  833 (49.39/ 8.64)	....................................................................................................RPgtkP....MSLSA...AAA.ALAAA..VAAAAG..SSS.....TAANAAA....TSPGAVS....SG..DSAAD..........S.LE.L..AD..SCLRSN....QNCAT..NSN
  834-  919 (48.29/ 8.25)	SGS...................................GGtN....STGA...................................aagsttpyggppsycRN...P....MSIGE...SHP.LPSEG..SPAS..........................AAPSpmqpSS..VSQPT..........SvPS.G..DQLITMSPHP....PASNNprSVQ
  920- 1019 (42.98/ 6.39)	PGTpcldhldkntpaptptdqhdsksinaspyhtpshpGG.G....GGGG.............................................................................stGSSGNGNSTEA.....QQQQQQSqsnsNMGNSSS....SS..SSGSN..........S.SSnS..SSLNALKTSP....RS........
 1020- 1103 (56.81/11.24)	.GT...................................LS.S....GIGS...............................................lkvRS...E....SSLGA...GSS.IGSGG..GVPMTPSIHSV.....YSSAHQT....AMANNLA....SKreSILQM..........L.QS.LkrPSLFCKDYET....LQSED..I..
 1202- 1272 (61.66/12.95)	NGG...................................GG.G....GGG..................................................................gvgACD.NGTSN..NGSCQPLLGHG.....QIKME.......LG............CDGSGagrdgagtgvA.GS.....GMGGANGTP....DRNGP....S
 1273- 1385 (48.73/ 8.40)	SGN...................................GD.G........allgeheikkekeekgsnfltdqdlqpsiddlnqifddggpfnddsdlhnTP...P....GSNKS.......CSGSG..GFSEEGK...R.....FPSSNHH....SVNSGML....SP..KELSQ..........M....F..PTPPSIDPHP....NSS.......
 1536- 1604 (70.00/15.87)	.GT....................................T.S....GIGG..................................................I......................GGSA..GGLGLGLLPII.....KQELGNL....TIPQPLS....TP..NSL............L.GG.L..NNLNGSINHPysnpPSQGA..QSQ
 1632- 1695 (41.93/ 6.02)	AGA...................................SG.GlfhpGMGG..................................................IP..vPlrqgMSPIS...PATpGGSMR..VPTPQG..GSC.....PLPYPSP....LGGAAAG....SP..NPM............................................
 2362- 2418 (55.01/10.61)	................................................................................................................SSS...SSS.ASVSG..GASGSSSLSG.......GSMNQP...............GG..NSMGQ..........NrGD.G..PGQSPMPPPP....PS..TpdSSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.25|      10|      15|     251|     263|       4
---------------------------------------------------------------------------
  251-  263 (17.57/13.35)	PGSPSAAgvnGGG
 2847- 2856 (21.68/ 7.67)	PGSPSQF...EGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.71|      47|     498|    2434|    2487|       5
---------------------------------------------------------------------------
 2434- 2487 (73.47/70.58)	ENRD...QLNTSSA.SPADGmRIDDDgkdpphIVLYIVEPFTCGS....DSPDVERLACLSL
 2936- 2990 (70.24/46.40)	QNTDdplQQNQSSTeHPLDS.NITAD......VLRYVLEGYNLLSwlamDSNTHDRLSCLPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     185.82|      59|     498|    2176|    2248|       6
---------------------------------------------------------------------------
 2176- 2248 (94.03/91.30)	TIQgPltWRQFHRLAGR.GTGQCEpqpipslivGYekDWLSLAP....YALHYWDKL....LLEPYSYPR..DVAYVAIVPDND
 2678- 2747 (91.78/55.92)	TVQ.P..WRLVVGRIGRiGHGELK.........GW..SWLLSKPnlqrASKHLKDICeqcsLMHPIAVPSilSACLVTLEPDSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      80.00|      18|      22|     423|     440|       7
---------------------------------------------------------------------------
  399-  415 (22.19/ 8.10)	.NSSSNQTATPVTA....IPSI
  423-  440 (30.71/14.72)	ANNASERSSGPINA....TSNQ
  443-  464 (27.09/11.90)	AGNISSNSSNPPTArnkdTPNE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      68.84|      14|      15|    1983|    1997|       8
---------------------------------------------------------------------------
 1780- 1791 (23.94/11.18)	GTGVGTN.GTS..GG
 1983- 1997 (19.00/12.68)	GTAKAIKmEESGSGG
 2000- 2013 (25.90/12.89)	GTLVATG.GASATGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.17|      19|     498|    1412|    1435|       9
---------------------------------------------------------------------------
 1386- 1404 (34.08/ 8.58)	PGGGGCLSDGGIAIDTLVD
 1417- 1435 (36.09/19.14)	PGSGSNLPNLGSPQEEPID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.67|      13|      22|    1292|    1304|      10
---------------------------------------------------------------------------
 1292- 1304 (23.09/12.43)	EKGSNFLTDQDLQ
 1315- 1327 (25.58/14.71)	DDGGPFNDDSDLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.21|      15|      16|    1851|    1865|      13
---------------------------------------------------------------------------
 1851- 1865 (27.80/14.45)	GTNWMDSVTAPAETA
 1869- 1883 (26.41/13.28)	GTSGNGGVTGGRSKA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.16|      37|     695|    1109|    1146|      14
---------------------------------------------------------------------------
 1109- 1146 (63.96/52.67)	LLYDyTCVDAWMNHPVKRMRLAMEE..NRLVKKIRNLD..LY
 1806- 1846 (60.20/43.43)	LLYD.TALNIFRDHNFKSCTLCVCNagTKCVGNIRGADsgLY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.39|      29|     262|    1441|    1471|      18
---------------------------------------------------------------------------
 1441- 1471 (52.24/29.59)	FLPPPicPY.VGSSKYAPLPSLPSQLIIPQIP
 1706- 1735 (51.16/23.12)	LLPPP..PYdVAIASPANSVATPSSYHSKQFP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.97|      20|      23|     276|     297|      20
---------------------------------------------------------------------------
  276-  297 (28.60/17.72)	AGNGGAanASATIASTDASEPR
  302-  321 (36.37/17.39)	APFGLA..GTLTGQSYKASDPH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20902 with Med13 domain of Kingdom Metazoa
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