<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20901

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTHQNHQTNGASLEDCHTNLFALTDLCGIRWRQLVLGERPNAAGDPLDDPVVRSYSKCLAVDILCVWRRVVAPKPKPKPEPEPSSMFDMSIPGTGNIGPVVHPPLSLTAAKELWIFWYGEEPDLTDLVAPELLNSSEAGDKGSWENGLSYECRSLLFKALHNVIERCLLSRGFVRIGRWFVHPSSNGERVFGKSSHHASFSFAFFVHGDSTVCASMDIREHPPVRLLTMKHLEEAQAQQPTANSATGGAPNGPASPPSAATGINGCGSATPGSPGGGAGVTNTSSGSGAVSSSDGATEPREVILAPFGLAGTLTGQSYKASDPHTQKILDDWSAFYPISNKHGGGMSDGTDHVPPIVEILVGKVKMRYPSRYVLVADMDDWTASSETRSSGAGSSNQTTSPVTTAASIAASVLSRINNSTGGGGTINSSSSCSSASNSNQPTVGSGSGAGVGAPNRPKDPSTSGGSSGLPSSPTGGSLRQRNHHKSMMTPPLTVPESPSNDLGNPLSMSAALINKSPAVILPERVWKDCIMHAAPPPQPASTTSATTGTGSSSTTTSTTTTTTPGGGGGVTIKTEPKDTSGSSNSSSSGNSSATNSGNSNSGGGDENSSGAANGVDANGNSSVWEISDPTAKVSCCCIKCCKRPPSSSSSSSSSSSSTSSSASGRSQHHQLQQQAIGAAAASSSCSVVATAGSNMYASISSPGTPSGGGVGGSIHHHPKSSSSSFPITYPGSGGVSSRGDKSYHHYHHGGGIGSQSSKDHHHHHHHHHRPARIAFHKRPPQEALFRPGSKLISLSAAAALAASAAASASSTAANAAASSPGAVSSGDSAADSLELADPCLRSNQNCAANSAGSNATGTAAPGSTTPYGGPPSYCRNPMSIGDSHPLPSEGSPASAAPSPMQPSSVSQPTSVPSGDQLITMSPHPPASNNPRSVQPGTPCLDHLDKNTPAPTPTDQHDSKSINASPYHTPSHPGGGGPTGNSSGTGSDAQQQSQSGLNMGNSSSSSSSSAGSNSSSTSNSLNALKTSPRNGGTLSSSAGIGGLKVRSESSLGAGSSIGSGGGVPMTPSIHSVYSSAHQTAVANNLASKRESILQMLQSLKRPLLFCKDYETLQSEDIPSTSQLLYDYTCVDAWMNHPVKRMRLAAEEYRLVKKIRNLDLYANEHSRTMVGSSAGTSGTGGPNASNGMLLKGLTAGSEPSDGSLSDVVGNQNTLGAGGVGAACDNGSVPPLIGQIKMEIGCEIGAAGQQQGGGVAVQAAGGVTGPGGVSTGSANGTPDRNGTSGDGGALLGEHEIKKEKEDKGAGAYSLLTDQDLQPSIDDLNQIFDDGGPFNDDPDLHNTPPGSNKSSGGGSGGFSEDSKRFPGSNHHHHSVNSGMLSPKELSQMFPTPPSLDPHPNSSPGGGGCLSDGGNAIDTLVDLQMSLSSSGVGSGNGGGGGGSGPVPIVPNLGSPQEEPIDDWSFVFLPPPLCPYVGSSKYAPLPTLPSQQLMPPILPGSTAASLVYKSTRQKQKEQAAVEREKQKLREQAEREREREQQQESQQSSQSESNTQNPCGGGVAPVSSLNAPPGLGLGLLPMIKQELGGGGLTIPQPLSTPNSLLGGLNNLNGSLNHPYSNPPSQGAQSQPHSRPPSVNSLPGGIMGGGGAGMLSPSPAGGGTPGGGLFHPGMGGIPVPLRQGMSPISPATPGGSMRVPTPQGSCPLPYPSPLGPAGSPNPMGSHFRRNTPLLPPPPYDVAIASPANSVATPSSYHSKQFPLDGVDGGSGGPGSNRGPMTPSSTGGGGGGPLGPSTVNQPLSSAGGCAAGVAGMNATGTLGNRTGSIETNALLVNVLLYDTALNIFRDHNFKSCTLCVCNAGAKCVGNIRGADSGLYLPLPGTNWMDSVTAPADSSVAEAGKVGGGGARGRAGALAHLGLGSSGAFGGMLGSPAVGSSNGGSSNDKTVTINTDSLQNGYLDEDPIDCQCGFSAVVNRRLAHRAGLFYEDELEITSMAEDPAVHKKSSLFEFLNGTARAIKMDESGSGGASSGNQVSANDSLPLTLKVMDLLREQCSVVQSSSNSIHRAVNRIRGALFGRSIGECGAVHLLEYVDANDVISMALEQGRLQAINESKQDLEQSSSASSSSSSSTAGVLVKGGTLRGMMNVHKWAFLRAGGPKSNQDIKRIMMSMQPLLQDAFHKRCTTRLWDAPYTILGPLTWRQFHRLAGRGTGQCEPQPIPSLIVGYEKDWLSLAPYALHYWDKLLLEPYSYPRDVAYVAIVPDNDYVVAKVRTYFKELSTTYEMCKLGRHTPIKGWDGVLRVGSQRVLKETQNSNQDEWFTNMGVDQQRRNGTATAAGSGGPSGLNELLRLYAQTCQQQLAPYLSKVPSDKSLLDPPESHHHTSSSSSAGASLGGGGSSSGGGAPGSSSLSGGSSMGQPGGSAMGQNRGDGGPGQSPMPPPPPSTPDPSQPGDKAPNTPKFDHDSENRDQLNTSSASPADGMRIDDDGKDPPHIVLYIVEPFTCGNDSPDVERLACLSLLRCYSNILNAVPESIRSNISVQIVSLESILELGRSRNRLRLSDHMRCLALSVFSQSRKYLAHMNTVKSLTGFGTAANAEQFIKRKDDKNRVPYRLYTPPYVLARSCEKSENTESFGKTSMKQQCSIMYCSYCLSEDQSWLLAVATDDRGEFLETVTINIDIPNRGRRKRASARRYGLQKLMDFILGLISQTVQPWRLVVGRIGRIGHGELKGWSWLLSKPNLQRASKHLKDICEQCSLMHPIAVPSILSACLVTLEPDSDLRVMSDQFTPDERFSQRSMQSPLSTPQDATCTHILVFPTSAKAQSAQASFSVIGELDLGEDLNMVIMDGDDDDDGINMMDVFRCWDDLPMQQINMPHSRPGSPSQFEGNQQSPGESGSKGAGSRDGYGSQDSEEVGVVLQQPLAIGYLVSTAPTGRMPDWFWSSCPHMENVCPVFLRTALHLHSPTILQNTDDPLQQNQSSTEHPLDSNITADVLRYVLEGYNMLSWLAMDSNTHDRLSCLPIHVQLLMQLYHMTAALA
Length3032
PositionMiddle
OrganismAnopheles dirus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.05
Grand average of hydropathy-0.427
Instability index56.17
Isoelectric point6.23
Molecular weight315174.46
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20901
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|    2534.66|     493|     500|    1255|    1748|       2
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  117-  628 (557.45/139.10)	WYGEEPDLTDLvaP...ELLN...........SSEAG........DKGSWENGLSYECRSL.....LFKALHNV.IErcllsrgfVRIGRWF...VHPSSNG..ERV..FGKSSH.HASFSF.AFFVHG...DSTVCASmDIREHPP..vrLLT.MKHLE...............EAQAqQPTANSATGGA...................................pngpASPPSAATG.INGCGS............ATPG...S.PGGGA..G.....VTNTSSG......SGAVSssdgateprevilapfglagTLTGQSYKAS....................................DPH....TQ........KILDDwsafypisnkhGGGMSDGTD.H...........VPPiveilvGKV.....KMRYPSRYVLVA....DMDDWTASSETR......SSGAGSSNQT....TSPVTTAASIAasvlSRINNSTGGGG.......TINSSSSCS..S......ASNSnqpTVGSGSGAGVG.......AP................N....RPK.DPST...SGGSSGLPS..SPTGGSlrqrnhhkSMM.........TPpltVPESPSNDLGNPL...SMSAALINKSPAVILPER..V.WKDcimHAAPPPQPASTTSATTGTGSSSTTTSTTTTTTPGGGGGVTIKT...EPKDTSG.....S.SNSSSSGNSSATNSGNSNS.GGGDENSSGAANGVDANGNSSVWEiSD
  680-  838 (72.37/11.54)	.......AASS..SC..SVVA...........TAGSN........MYASISSPGTPSGGGVggsihHHPKSSSSSFP........ITY.........PGSGGVSSR...GDKSYH.HYHHGG.GIGSQS...SKDHHHH.HHHHHRPariaFHK.RPPQEalfrpgsklislsaaAALA.ASAAASASSTAA......................................................................................................................................................................................................................................................................................NAAASSPGAV....SSGDSAADSLE...lADP.............................................................................................................................................................................................................................................................................................
  853- 1200 (314.72/75.32)	...........................................................................................................................................................................................................................SNA.TGT....AAPG..STTPYGGPPS..........ycRNPM...SiGDS......HPLPSEGSPAS......AAP..........................SPMQPSsvsqptsvpsgdqlitmsphppasnnprsvqpgtpcLDH....LD........K...............NTPAPTPTDQHdsksiN.....ASP......YHT.....PSHPGG.GGPTG....NSSG.TGSDAQQQSqsgLNMGNSSSSSSssagSNSSSTSNSLN....AL.KTSPRNGGTLSSSA....GIGGLKVrS......ESSL...GAGSSIGSGGG....VPMTPsihsvyssahqtavanNL..ASKRESILQ...MLQSLKRPLLFCK.............DY...............ETLQSED.....IPSTS..QLLYDYT....CVDAWM.NHP...VKRMRLAAEEYRLVKKIRNLDLYANEHSRTMVGSSAGTSGTGGPNASNGMLL.............KGLTAG.........................SEPSDG.....
 1201- 1623 (684.78/174.04)	......SLSDV..VGnqNTLG...........AGGVG..........AACDN.GSVP...........PLIGQIKME........I..G.CE...IGAA..........................................................................................GQQ....................qgggvavQAA.GGV....TGPGGVSTGSANGTPD............RNGT...S.GDGGALLGEHEIKKEKEDKG......AGAYS....................LLTDQDLQPS....................................IDD....LN........QIFDD...........GGPFNDDPDLH.....N.....TPP......GSN.....KSSGGGSGGFSE....DSKRFPGSNHHHHS...VNSGMLSPKEL....SQMFPTPPSLD....PHPNSSPGGGGCLSDGGNAIDTLVDLQM.S......LSSS...GVGSGNGGGGGGSGPVPIVP................NL..GSPQEEPID...DWSFVFLPPPLCPYVGS........SKY.........AP...LPTLPSQQLMPPILPGSTAASLVYKSTRQKQKEQAAV.ERE...KQKLREQAEREREREQQQESQQSSQSESNTQNPCGGGVAPVSSLNAPPGLGLGLLPMIK.QELGGGGLTIPQPLSTPNSlLGGLNNLNGSLNHPYSNPPSQGAQ.SQ
 1624- 2120 (633.61/159.12)	PHSRPPSVNSL..PG..GIMG...........GGGAG........MLSPSPAGGGTPGGGL.....FHPGMGGIPVP........LRQGMSP...ISPATPGGSMRVP.TPQGSC.PLPYPS.PLGPAG...SPNPMGS.HFRRNTP....LLP.PPPYD...............VAIA.SPANSVATPSSY....................hskqfplDGVdGGS....GGPGS.NRGPM..TPS............STG......GGGGGPLGPSTVNQPLSSAGgcaagvAGMNA....................TGTLGNRTGS....................................IETnallVNvllydtalNIFRD...........HN.FK.SCTLC.....V.....CNA......GA......KCVGNIRGADSG....LYLPLPGTNW.......MDS.VTAPADS....S..............VAEAGKVGGGGARGRAG.ALAHL.GLGS.SgafggmLGSP...AVGSSNGGSSNDKTVTINTD................SLqnGYLDEDPIDcqcGFSAV.VNRRLAHRAGL........F.YedeleitsmAE...DPAVHKKSSLFEFLNGTARAIKMDESGSGGASSGNQVsAND...SLPLTLKV.MDLLREQCSVVQSSSNSIHRAVNRIRG.........ALFGRSIGECGAVHlLEYVDANDVISMALEQ.....GRLQAINES...KQDLEQSSSAS.SS
 2121- 2495 (271.73/63.92)	SSSSTAGVLVK..GG..TLRGmmnvhkwaflrAGGPKsnqdikriMMSMQPLLQDA..........FHK.....RCT........TRLWDAPytiLGPLTWRQFHRLAgRGTGQCePQPIPSlIVGYEKdwlSLAPYAL.HYWDKLL....LEPySYPRD...............VAYV.....AIVPDNDYvvakvrtyfkelsttyemcklgrhtpiKGW.DGV..lrVGSQRVLKETQNSNQDewftnmgvdqqrRNGTataA.GSGGP.SGLNELLR..............LYA....................QTCQQQLAPY...........................................LS........KVPSD...........KS.LLDPPESH.....HhtsssSSA......GASlggggSSSGGGAPGSSSlsggSSMGQPGGSAMGQ.....NRGDGGPGQ.....SPMPPPPPS.T....PDP.SQPGDKAPNTPKFDH.DSENRDQL.N......TSSA...SPADGMRIDDDGKDPPHIVL................YI..VEP..........................................................................................................................................................................................................
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20901 with Med13 domain of Kingdom Metazoa
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