<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20900

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTHQNHQTNGASLEDCHTNLFALTDLCGIRWRQLVLGERPNAAGDPLDDPVVRSYSKCLAVDILCVWRRVVAPKPKPKPEPEPSSMFDMSIPGTGNIGPVVHPPLSLTAAKELWIFWYGEEPDLTDLVAPELLNSSEAGDKGSWENGLSYECRSLLFKALHNVIERCLLSRGFVRIGRWFVHPSSNGERVFGKSSHHASFSFAFFVHGDSTVCASMDIREHPPVRLLTMKHLEEAQAQQPTANSATGGAPNGPASPPSAATGINGCGSATPGSPGGGAGVTNTSSGSGAVSSSDGATEPREVILAPFGLAGTLTGQSYKASDPHTQKILDDWSAFYPISNKHGGGMSDGTDHVPPIVEILVGKVKMRYPSRYVLVADMDDWTASSETRSSGAGSSNQTTSPVTTAASIAASVLSRINNSTGGGGTINSSSSCSSASNSNQPTVGSGSGAGVGAPNRPKDPSTSGGSSGLPSSPTGGSLRQRNHHKSMMTPPLTVPESPSNDLGNPLSMSAALINKSPAVILPERVWKDCIMHAAPPPQPASTTSATTGTGSSSTTTSTTTTTTPGGGGGVTIKTEPKDTSGSSNSSSSGNSSATNSGNSNSGGGDENSSGAANGVDANGNSSVWEISDPTAKVSCCCIKSNQNCAANSAGSNATGTAAPGSTTPYGGPPSYCRNPMSIGDSHPLPSEGSPASAAPSPMQPSSVSQPTSVPSGDQLITMSPHPPASNNPRSVQPGTPCLDHLDKNTPAPTPTDQHDSKSINASPYHTPSHPGGGGPTGNSSGTGSDAQQQSQSGLNMGNSSSSSSSSAGSNSSSTSNSLNALKTSPRNGGTLSSSAGIGGLKVRSESSLGAGSSIGSGGGVPMTPSIHSVYSSAHQTAVANNLASKRESILQMLQSLKRPLLFCKDYETLQSEDIPSTSQLLYDYTCVDAWMNHPVKRMRLAAEEYRLVKKIRNLDLYANEHSRTMVGSSAGTSGTGGPNASNGMLLKGLTAGSEPSDGSLSDVVGNQNTLGAGGVGAACDNGSVPPLIGQIKMEIGCEIGAAGQQQGGGVAVQAAGGVTGPGGVSTGSANGTPDRNGTSGDGGALLGEHEIKKEKEDKGAGAYSLLTDQDLQPSIDDLNQIFDDGGPFNDDPDLHNTPPGSNKSSGGGSGGFSEDSKRFPGSNHHHHSVNSGMLSPKELSQMFPTPPSLDPHPNSSPGGGGCLSDGGNAIDTLVDLQMSLSSSGVGSGNGGGGGGSGPVPIVPNLGSPQEEPIDDWSFVFLPPPLCPYVGSSKYAPLPTLPSQQLMPPILPGSTAASLVYKSTRQKQKEQAAVEREKQKLREQAEREREREQQQESQQSSQSESNTQNPCGGGVAPVSSLNAPPGLGLGLLPMIKQELGGGGLTIPQPLSTPNSLLGGLNNLNGSLNHPYSNPPSQGAQSQPHSRPPSVNSLPGGIMGGGGAGMLSPSPAGGGTPGGGLFHPGMGGIPVPLRQGMSPISPATPGGSMRVPTPQGSCPLPYPSPLGPAGSPNPMGSHFRRNTPLLPPPPYDVAIASPANSVATPSSYHSKQFPLDGVDGGSGGPGSNRGPMTPSSTGGGGGGPLGPSTVNQPLSSAGGCAAGVAGMNATGTLGNRTGSIETNALLVNVLLYDTALNIFRDHNFKSCTLCVCNAGAKCVGNIRGADSGLYLPLPGTNWMDSVTAPADSSVAEAGKVGGGGARGRAGALAHLGLGSSGAFGGMLGSPAVGSSNGGSSNDKTVTINTDSLQNGYLDEDPIDCQCGFSAVVNRRLAHRAGLFYEDELEITSMAEDPAVHKKSSLFEFLNGTARAIKMDESGSGGASSGNQVSANDSLPLTLKVMDLLREQCSVVQSSSNSIHRAVNRIRGALFGRSIGECGAVHLLEYVDANDVISMALEQGRLQAINESKQDLEQSSSASSSSSSSTAGVLVKGGTLRGMMNVHKWAFLRAGGPKSNQDIKRIMMSMQPLLQDAFHKRCTTRLWDAPYTILGPLTWRQFHRLAGRGTGQCEPQPIPSLIVGYEKDWLSLAPYALHYWDKLLLEPYSYPRDVAYVAIVPDNDYVVAKVRTYFKELSTTYEMCKLGRHTPIKGWDGVLRVGSQRVLKETQNSNQDEWFTNMGVDQQRRNGTATAAGSGGPSGLNELLRLYAQTCQQQLAPYLSKVPSDKSLLDPPESHHHTSSSSSAGASLGGGGSSSGGGAPGSSSLSGGSSMGQPGGSAMGQNRGDGGPGQSPMPPPPPSTPDPSQPGDKAPNTPKFDHDSENRDQLNTSSASPADGMRIDDDGKDPPHIVLYIVEPFTCGNDSPDVERLACLSLLRCYSNILNAVPESIRSNISVQIVSLESILELGRSRNRLRLSDHMRCLALSVFSQSRKYLAHMNTVKSLTGFGTAANAEQFIKRKDDKNRVPYRLYTPPYVLARSCEKSENTESFGKTSMKQQCSIMYCSYCLSEDQSWLLAVATDDRGEFLETVTINIDIPNRGRRKRASARRYGLQKLMDFILGLISQTVQPWRLVVGRIGRIGHGELKGWSWLLSKPNLQRASKHLKDICEQCSLMHPIAVPSILSACLVTLEPDSDLRVMSDQFTPDERFSQRSMQSPLSTPQDATCTHILVFPTSAKAQSAQASFSVIGELDLGEDLNMVIMDGDDDDDGINMMDVFRCWDDLPMQQINMPHSRPGSPSQFEGNQQSPGESGSKGAGSRDGYGSQDSEEVGVVLQQPLAIGYLVSTAPTGRMPDWFWSSCPHMENVCPVFLRTALHLHSPTILQNTDDPLQQNQSSTEHPLDSNITADVLRYVLEGYNMLSWLAMDSNTHDRLSCLPIHVQLLMQLYHMTAALA
Length2830
PositionMiddle
OrganismAnopheles dirus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.05
Grand average of hydropathy-0.424
Instability index54.63
Isoelectric point5.94
Molecular weight295120.04
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20900
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|    1615.93|     203|     203|     407|     609|       1
---------------------------------------------------------------------------
  253-  456 (181.07/42.22)	PASP.P..SaatgiNGC.GSA.TPGSPGGGA...........................................................GvtNTS.......S.GSGA.VSSS....DGATEPREV.......IL......APFGL...AG................TLTGQSYKASDPHTQKilddwSAFYPISNK.....HG..GGMSDGTDhvPpiveilvgkvkmrypsryvlvadmDDWTASSETRSS...G..............AGSSNQT...............tspvttaaSIAASV.LSRINNSTG..GG......G.TINSSSSC..SSA..............SNSNQP....TVGSGSG..AGVGA.PN..R
  457-  671 (298.17/74.70)	PKDP.S..T.....SGG.SSG.LPSSPTGGSLRQ........................RN.HHKSMMTPPLTVP.ES...PSND.....LG..NPL.......S.MSAALINKS....PAVILPERV.WKD..CIM.H...AAPPPQ...PA................STTSATTGTGSSSTTT.....STTTTTTPG.....GG..GGVTIKTE..P........................KDTSGSSNSSSS...GNSSATNS.GNSNSGGGDENSS...............gaangvdaNGNSSV.W.EISDPTAkvSC......C.CIKSNQNCaaNSA..............GSNATG....TAAPGST..TPYGGpPS..Y
  672-  857 (218.53/52.61)	CRNP.M..S.....IGD.SHP.LPSEGSPASAAP........................SP.MQPSSVSQPTSV.......PSGD.........QLI.......T.MSP....HP....PASNNPRSV.QPGtpCLD.HldkNTPAPT...P......................TDQHDSKSINA.....SPYHTPSHP.....GG..GGPTGNSS..G........................TGSDAQQQSQSGlnmGNSS...S.SSSSSAGS..NSS.......................STSNS..LNALKTSPR..NG......G.TLSSSAGI..GGL..............KVRSES....SLGAGSS..IGSG.......
  858- 1093 (163.03/37.22)	...................GG.VPMTPSIHSVYS........................SA.HQTAVANNLASKR.ESilqMLQS.....LK..RPLlfckdyeT.LQSEDI.PS....TSQLLYDYT.CVD..AWMnH...PVKRMR...LAaeeyrlvkkirnldlyANEHSRTMVGSSAGTS.....GTGGPNASN.....GMllKGLTAGSE..P........................SD..GSL.SDVV...GNQNTLGA.G....GVGAACDN.............gsvppligqiKMEIGCeIGAAGQQQG..GGvavqaaG.GVTGPGGV..STG..............SANGTPdrngTSGDG.G..ALLGE.HEikK
 1094- 1212 (135.60/29.61)	EKED.K..G.....AGA.YSL.LTDQDLQPSIDD........................LN.QIFDDGGP...FN.DD...P..D.....LH..N....................................................................................................TPPGsnkssGG..GSGGFSED..S........................KRFPGSNHHHHS...VNSG...................................................MLSPKE..LS......Q.MFPTPPSL..DPH..............PNSS.P....GGGGCLS..DGGNA.ID..T
 1213- 1429 (205.98/49.13)	LVDL.Q..M.....SLS.SSG.VGSGNGGGG...........................GG.SGPVPIVPNLGSPqEE...PIDDwsfvfLP..PPL.......C....PYVGSS.kyaPLPTLPSQ.......QLM.......PPIL...PG................ST..AASLVYKSTRQK.....QKEQAAVER.....EK..QKLREQAE..R........................EREREQQQESQQ...SSQSESNT.QNPCGGGVAPVSS..................lnappGLGLGL.LPMIKQELG..GG......GlTIPQPLST..PNSllgglnnlngslnhPYSNPP....SQGAQSQ..PHSRP.PS..V
 1430- 1587 (184.08/43.06)	NSLP.GgiM.....GGG.GAGmLSPSPAGGGTPG........................GGlFHPGMGGIP..VP.LR...QG..............................MS....P..ISPAT...PG..GSM.R....VPTPQgscPL................PYPSPLGPAGSPNPMG.....SHFRRNTP.............LLPPP..P........................YDVAIASPANSV...ATPSSYHS.KQFPLDGVDGGSG................gpgsnrgPMTPS........STG..GG......G............................................G..GPLG..PS..T
 1588- 1808 (162.28/37.01)	VNQPlS..S.....AGGcAAG.VAGMNATGTLGNrtgsietnallvnvllydtalnifRD.HNFKSCT..LCVC.NA...GAKC.....VG..NIR.......G.ADSGLY..L....P...LPGTN.WMD........................................SVTAPADSSVAEA.....GKV...........GG..GGARGRAG..A........................LAHLGLGSSGAF...GGMLGSPAvGSSN..GGSSNDKtvtintdslqngyldedpidcqcGFSAVV.NRRLAHRAG.............LFYEDEL..EIT..............SMAEDP....AVHKKSSlfEFLNG.TA..R
 1811- 1929 (67.17/10.63)	KMDE.S..G.....SGG.ASS.GNQVSANDSLPL........................TL.KVMDLLREQCSVV.QS...SSNS.....IH..RAV.......NrIRGALFGRSigecGAVHLLEYVdAND..VIS.M...ALEQGR...LQ................AINESKQDLEQSSSAS.....SSSSSST...........AGVLVK..............................................................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     534.25|     164|     501|    2130|    2311|       2
---------------------------------------------------------------------------
 2130- 2311 (252.35/113.13)	GSGGPSGLNeLLRLYaqTCQQQLAPYLSKVPSDKSlLDPPESHHHTSSSSSAGASlgGGGSSSGGGAPGSSSLsgGSSMGQPggSAMGQNRGDGGPGQSP......MPPPPPSTPDPSQPGDKApNTPKFDHDSENRDQLNTSSA.SPADGmRIDDDgkdpphIVLYIVEPFT....CGNDSPDVERLACLSL
 2640- 2814 (281.89/94.68)	GDDDDDGIN.MMDVF..RCWDDLPMQQINMPHSRP.GSPSQFEGNQQSPGESGSK..GAGSRDGYGSQDSEEV..GVVLQQP..LAIGYLVSTAPTGRMPdwfwssCPHMENVCPVFLRTALHL.HSPTILQNTDDPLQQNQSSTeHPLDS.NITAD......VLRYVLEGYNmlswLAMDSNTHDRLSCLPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.32|      35|    1907|     157|     191|       4
---------------------------------------------------------------------------
  157-  191 (65.84/43.21)	FKALHNVIERCLLSR........GFVRIGRWFV...HPSSNGERVF
 2067- 2112 (52.48/32.76)	FKELSTTYEMCKLGRhtpikgwdGVLRVGSQRVlkeTQNSNQDEWF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20900 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DDWTASSETRSSGAGSSNQTTSPVTTAASIAASVLSRINNSTGGGGTINSSSSCSSASNSNQPTVGSGSGAGVGAPNRPKDPSTSGGSSGLPSSPTGGSLRQRNHHKSMMTPPLTVPESPSNDLGNPLSMSAALINKSPAVILPERVWKDCIMHAAPPPQPASTTSATTGTGSSSTTTSTTTTTTPGGGGGVTIKTEPKDTSGSSNSSSSGNSSATNSGNSNSGGGDENSSGAANGVDANGNSSVWE
2) LAPYLSKVPSDKSLLDPPESHHHTSSSSSAGASLGGGGSSSGGGAPGSSSLSGGSSMGQPGGSAMGQNRGDGGPGQSPMPPPPPSTPDPSQPGDKAPNTPKFDHDSENRDQLNTSSASPADGMRIDDDGKD
3) LVDLQMSLSSSGVGSGNGGGGGGSGPVPIVPNLGSPQEEPIDDWS
4) NSAGSNATGTAAPGSTTPYGGPPSYCRNPMSIGDSHPLPSEGSPASAAPSPMQPSSVSQPTSVPSGDQLITMSPHPPASNNPRSVQPGTPCLDHLDKNTPAPTPTDQHDSKSINASPYHTPSHPGGGGPTGNSSGTGSDAQQQSQSGLNMGNSSSSSSSSAGSNSSSTSNSLNALKTSPRNGGTLSSSAGIGGLKVRSESSLGAGSSIGSGGGVPMTPSIHSVYS
5) PLPTLPSQQLMPPILPGSTAASLVYKSTRQKQKEQAAVEREKQKLREQAEREREREQQQESQQSSQSESNTQNPCGGGVAPVSSLNAPPGLGLGLLPMIKQELGGGGLTIPQPLSTPNSLLGGLNNLNGSLNHPYSNPPSQGAQSQPHSRPPSVNSLPGGIMGGGGAGMLSPSPAGGGTPGGGLFHPGMGGIPVPLRQGMSPISPATPGGSMRVPTPQGSCPLPYPSPLGPAGSPNPMGSHFRRNTPLLPPPPYDVAIASPANSVATPSSYHSKQFPLDGVDGGSGGPGSNRGPMTPSSTGGGGGGPLGPSTVNQP
6) QGGGVAVQAAGGVTGPGGVSTGSANGTPDRNGTSGDGGALLGEHEIKKEKEDKGAGAYSLLTDQDLQPSIDDLNQIFDDGGPFNDDPDLHNTPPGSNKSSGGGSGGFSEDSKRFPGSNHHHHSVNSGMLSPKELSQMFPTPPSLDPHPNSSPGGGGCLSDGGNA
7) QINMPHSRPGSPSQFEGNQQSPGESGSKGAGSRDGYGSQDSE
8) TQNSNQDEWFTNMGVDQQRRNGTATAAGSGGPSG
9) VRLLTMKHLEEAQAQQPTANSATGGAPNGPASPPSAATGINGCGSATPGSPGGGAGVTNTSSGSGAVSSSDGATEPREVILAP
379
2152
1213
647
1276
1046
2663
2103
224
625
2282
1257
871
1591
1209
2704
2136
306










Molecular Recognition Features






MoRF SequenceStartStop




NANANA