<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20899

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTHQNHQTNGASLEDCHTNFFALTDLCGIRWRQLVLGERPNAAGDPLDDPVVRSYSKCLAVDILCVWRRVVAPKPKPKPEPDPSSMFDMSIPGTGNSGSVVHPPLSLTAAKELWIFWYGEEPDLTDLVAPELLNSSEAGDKGSWENGLSYECRSLLFKALHNVIERCLLSRGFVRIEQWFVHPTSNDERVFGKSSHHASFSFTFFVHGDSTVITAMDIREHPPVRLLTMKHLEEAQRAAAPGAAAATASTTGGPASPDGGLNGAPGCAPGSPGGSSNSAVVPADDAIEPREVLLAPFAITGTLTGQSYRASDPHTQKILDDWSAFYPITNKHSGLADGADSMPPLVEVLVGKMKMRYPSKYVLVPDMDDWTSAGDARSNSSSSSSSSNSSNTNSNQTTTPATAAASIAASVLSRINSASERSGGGVASNSTTTTSNTINTTSNQTAGSSSSNAAAAAASSARPKDTANDAAAPSPTGTLRQRNHHKSMMTPPLTVPESPSNDLGNPLSMSSALINKSPAVILPERVWQDCIMHASTPAATAASSASSGTTATTQTSAPGSVTIKTEPKDNTSGSNSSTNNNNSNNSNSSSGGGDENSSGAANGVDANGNSSVWEISDPTVKVSCCCIKSNQNCAASSGGGGGNSGASNTTGAAPGSTTPYGGPPSYCRNPMSIGDSHPLPSEGSPASAAPSPMQPSSVSQPTSVPSGDQLITMSPHPPASNNPRSVQPGTPCLDHLDKNTPAPTPTDQHDSKSINASPYHTPSHPGGGGGGSSGGTTEAGQQQQASANLMGNSSSSSSSNSSSNGSNSSSNSSNSLSALKASPRSSLSSSGIGSLKVRSESSLGAGGSCSLGSGGGSGGGVPMTPSIHSVFSSAHQTAMANNLASKRESILQMLQSLKRPSLFCKDYETLQGEDIPSTSQLLYDYTCVDAWMNHPVKRMRLAAEENRLVKKIRNLDLYANEHSRTMASGPGLAGSGNSTNGGIGTNGMLMKGAAEASEALAEALSGGRPGTGGGSDNGAPNNGAGCTPLLGQIKMEIGCDGSQAGAAVGSANGGTPDRNGASAGNGGAGDGALLGEHEIKKEKEDKGSIFLTDQDLQPSIDDLNQIFDDGGPFNDDPDLHNTPPGSNKSSSGSGGFSEESKRFPSSNHHSVNSGMLSPKELSQMFPTPPSLDPHPNSSPGGGGCLSDGGSIALDTLVDLQMSLSSGAGSGGGNGGGASSVPPIPNLGSPQEEPIDDWSFVFLPPPICPYVGSSKYAPLPSLPSQQVMPPIPTSTVAGLVYKSTRQKQKEQAAAEREKQKQREQAEREREREQKQEQQQDQPDGQPESGGQGGAGAGPGRPVGVAGPTTTALGVGLGLLPIVKQEVGGLTVPQPLSTPNSLLGGLSGLNGGSLAHPYSNPPSQGAQSQPHSRPPSVNSLPGGIMGGGAGMLSPSPAGTSGGGLFHPGGMGGIPVPLRQGMSPISPATPGGSMRVPTPQGSCPLPYPSPLGGAGSPNPMGSLSFRRTTPLLPPPPYDVAIASPANSVATPSSYHSKQYPLDGVDSGGPGSNRGPMTPSSTGGSGPLGAGTVHPPLSSSGVGCGTGTPAGSRSIETNALLVNVLLYDTALNIFRDHNFKSCTLCVCNAGAKCVGNIRGADSGLYLALPGTNWMDSVTAAGTEPTPSTTPGPAGGRSKASALAHLGLGGSSSAFGTGMLGSPAVGRQEDKMAAVTINTDSLQNGYLDEDPIDCQCGFSAVVNRRMAHRAGLFYEDEMEITGMAEDPAVHKNGSLFEFLNGTAKAIKLEDADRGTLATSAGGSSSSAAGGDSLPLTLKVMDLLREQCSVVQSSSNSIHRAVNRYRGPLFGRGAENGAVHLLEYVDANDVISLALEQGRLQAINESKMDVDQQQQQQQSSSGALVKGGTLRGQMNVHKWPFLRAGGPKSNQDIVRIMKSMQPLLQDAFHKRCTTRLWDAPYTIQGPLTWRQFHRLAGRGTGQCEPQPIPSLIVGYEKDWLSLAPYALHYWDKLLLEPYSYPRDVAYVAIVPDNDYVVAKVRTYFKELSTTYEMCKLGRHTPIKGWDGILRVGSQRVLKETQNSNLDEWFTNMGVDQQRKNGTTTAGSASSSSSSGLNELLRLYAQTCQQQLAPYLSKVPSDKSLLDPPESHHHTSSSASASASLGGGAAGASSLGGGSMGQPGGNAMGQNRPDGPGQSPMPPPPPSTPDSSQPGDKAPNTPKFDHDSENRDQLNTSSASPADGMRIDDDGKDPPHIVLYIVEPFTCGNDSPDVERLACLSLLRCYSNILNAVPDSIRSNISVQIISLESILELGRNRNRLRLSDHMRCLALSVFSQSRKYLAHMNTVKSLTGFGTAANAEQFIKRKDDKNRVPYRLYTPPYVLARSCEKSENTESFGKTSMKQQCSIMYCSYCLSEDQSWLLAVATDDRGEFLETVTINIDIPNRGRRKRASARRYGLQKLMDFILGLISQTVQPWRLVVGRIGRIGHGELKGWSWLLSKPNLQRASKHLKDICEQCSLMHPIAVPSILSACLVTLEPDSDLRVMSDQFTPDERFSQRSMQSPLSTPQDATCTHILVFPTSAKAQSAQASFSVIGELDLGEDLNMVIMDGDDDDDGINMMDVFKCWDDLPMQQINMPHSRPGSPSQFEGNQQSPGESGSKGAGSRDGYGSQDSEEVGLVLQQPLAIGYLVSTAPTGRMPEWFWSSCPHMENVCPVFLRTALHLHSPTILQNTDDPLQQNQSSTEHPLDSNITADVLRYVLEGYNLLSWLAMDSNTHDRLSCLPIHVQVLMQLYHMTAALA
Length2794
PositionMiddle
OrganismAnopheles arabiensis (Mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.05
Grand average of hydropathy-0.444
Instability index52.20
Isoelectric point5.80
Molecular weight292664.12
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20899
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|    1701.92|     402|     411|     236|     646|       1
---------------------------------------------------------------------------
  236-  373 (119.64/27.26)	............................................................................................................................................................................................................................................................................................................................................................................................................................QRAAA.......PGA.........AA.ATASTTGGPAS....P....DG...GLNGAPGCA...PGSPGGSSNSAVVPA.DDAI...........EPREV.............LLAP....FAI....TGTLTGQSYRASDPHTQKILDDWSAFYPITNKHSGLADGADSMPPLVEvlVGKMKMRYPSKYVLVPDMDDWTSA
  374-  790 (536.08/150.55)	GDARSNSSSSS........SSSNSSNTNSNQTTTPATAAASIAASVLSR.INS...ASERS...GGGVASNSTTTTSNT.INTTSNQTAGSSSSNAAAAAASSARPKDTANDAAapSPTGTLRQrnHHKSMMTPPLTVP.ESPSND.....LGNPLSMSSALINKSPAVILPERVWQDCIM.HASTP...AAT.............AASSASSGTTATTQTSAPGSVtiKTEPKDNTSGSNSSTNNNNSNN..............SNSSSGGGDENSSGAANGVDANGNSSVwEISDPT.............VKVSCCC....IKSNQNC...........................................AASSGGGGGNSGA...............................snttgaaPGS.........T.....TPYGGPPSycrnPmsigDShplPSEGSPASAapsPMQPSSVSQPTSVPS.GDQLitmsphppasnNPRSVqpgtpcldhldknTPAP.....TP....TDQHDSKSINASPYHT..............PSHPG.GGGGGSSGGTTE..AGQQQQ..ASANL....M......
  791- 1124 (411.70/106.74)	GNS.SSSSSSN........SSSNGSNSSSNSSNSLSALKASPRSSLSSSgIGSlkvRSESSlgaGGSCSLGSGGGSGGG.VPMTP..........SIHSVFSSAHQTAMANNLA..SKRESILQ..MLQSLKRPSLFCK.DYETLQ......GEDIPSTSQLLYDYTCV........DAWMnHPVKRmrlAAEenrlvkkirnldlYANEHS.....RTMASGPG.L..........AGSGNSTNGGIGTNgmlmkgaaeasealAEALSGGRPGTGGGSDNGAPNNGA..........................GCTPllgqIKMEIGC...........................................DGSQAG...........................................................aAVGSANGG..T....P....D.....RNGA...S...AGN.GGAGDGALLGE.HEIK...........KEKED.............KGSI....F.........LTDQDLQPSIDDLNQIFDDGGPFN....................................DDPDLHN.TPP
 1125- 1546 (533.65/140.51)	GSNKSSSGSGGfseeskrfPSSNHHSVNSGM.LSPKELSQMFPTPPSLD.PHP...NSSPG...GGGCLSDGGSIALDTlVDLQMSLSSGAGSGGGNGGGASSVPP........................I..PNLGSPqEEPIDDwsfvfLPPP..I.CPYVGSSKYAPLPSLPSQQ.VM..PPIP...TST.............VAGLVYKSTRQKQKEQAAAE...REKQKQREQAEREREREQKQEQ..............QQDQPDGQPE..SGGQGGAGAGPGRPV.GVAGPTttalgvglgllpiVKQEVGG....LTVPQPL...........................................STPNSLLGGLSGLnggslahpysnppsqgaqsqphsrppSVNSL.......PGGimgggagmlSP.SPAGTSGGGLF....H....PG...GMGGIP..V...PLRQGMSPISPATPG.GSMR...........VPTPQ.............GSCP....LPY....PSPLGGAG..SPNPMGSLSFRRTTPLLPPPPYDVAIASPANS........VATPSSYHSKQYPL..DGVDSGGP
 2095- 2243 (100.85/20.44)	GTTTAGSASSS........SSSG...................................................................................................................................................................................................................................................................................................................lnellrlyaqtcqqqlapylskvpsdkslldppeshhhtsssaSASASLGGGAAG............................ASSL.......GGG........sMG.QPGGNAMGQNR....P....DG..................PGQSPMPPPPPStPDSS...........QPGD...............KAPntpkFDHdsenRDQLNTSS..ASPADGMRIDDD....................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     270.89|      86|     109|    1547|    1641|       2
---------------------------------------------------------------------------
 1547- 1641 (141.37/83.18)	GSNRGP.MTPSSTGGSGPLGAgTVHPPL..SSSGVGCG.TGTPA.GSRSIETNALLVNVllyDTALNIFRDHNFKSCTlCvcnaGAKCVGNIRGAD.SGLY
 1657- 1748 (129.52/57.69)	GTEPTPsTTPGPAGGRSKASA.LAHLGLggSSSAFGTGmLGSPAvGRQEDKMAAVTINT...DSLQNGYLDEDPIDCQ.C....GFSAVVNRRMAHrAGLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     210.75|      63|     501|    1943|    2028|       3
---------------------------------------------------------------------------
   16-   81 (112.50/55.95)	CHTNFF.ALTDLCG.IRWRQL.VLGERPNAAGDPLDDP.VVRSYSK...CLAVDILCVWRRVVApkpKPKPEP
 1946- 2015 (98.25/90.00)	CTTRLWdAPYTIQGpLTWRQFhRLAGRGTGQCEPQPIPsLIVGYEKdwlSLAPYALHYWDKLLL...EPYSYP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.80|      23|     501|    2253|    2275|       4
---------------------------------------------------------------------------
 2253- 2275 (43.53/30.74)	YIVEPFT....CGNDSPDVERLACLSL
 2752- 2778 (36.26/23.93)	YVLEGYNllswLAMDSNTHDRLSCLPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.92|      16|    1221|    1396|    1412|       9
---------------------------------------------------------------------------
 1396- 1412 (28.35/16.93)	YSNPPSQGAqSQPHSRP
 2620- 2635 (34.58/16.94)	WDDLPMQQI.NMPHSRP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20899 with Med13 domain of Kingdom Metazoa
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