<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20898

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTHQNHQTNGASLEDCHTNFFALTDLCGIRWRQLVLGERPNAAGDPLDDPVVRSYSKCLAVDILCVWRRVVAPKPKPKPEPDPSSMFDMSIPGTGNSGSVVHPPLSLTAAKELWIFWYGEEPDLTDLVAPELLNSSEAGDKGSWENGLSYECRSLLFKALHNVIERCLLSRGFVRIEQWFVHPTSNDERVFGKSSHHASFSFTFFVHGDSTVITAMDIREHPPVRLLTMKHLEEAQRAAAPGAAAATASTTGGPASPDGGLNGAPGCAPGSPGGSSNSAVVPADDAIEPREVLLAPFAITGTLTGQSYRASDPHTQKILDDWSAFYPITNKHSGLADGADSMPPLVEVLVGKMKMRYPSKYVLVPDMDDWTSAGDARSNSSSSSSSSNSSNTNSNQTTTPATAAASIAASVLSRINSASERSGGGVASNSTTTTSNTINTTSNQTAGSSSSNAAAAAASSARPKDTANDAAAPSPTGTLRQRNHHKSMMTPPLTVPESPSNDLGNPLSMSSALINKSPAVILPERVWQDCIMHASTPAATAASSASSGTTATTQTSAPGSVTIKTEPKDNTSGSNSSTNNNNSNNSNSSSGGGDENSSGAANGVDANGNSSVWEISDPTVKVSCCCIKCCKRPPSSSSSSSSSSASSSASGRTQQQQQQQHTIGAAGSSSANATGGSNYASISSPGGGGAAAAGGGGSLHPHPKSSYSITYPGSSSGSSRSSHYHHHQSTKDHHHHHHHHHHHRPQRVAFHKRPPQEALFRPGTEPLSLSAAAALAAAAAAAAANAASSPGAVSSGDSAADSLELADTCLRSNQNCAASSGGGGGNSGASNTTGAAPGSTTPYGGPPSYCRNPMSIGDSHPLPSEGSPASAAPSPMQPSSVSQPTSVPSGDQLITMSPHPPASNNPRSVQPGTPCLDHLDKNTPAPTPTDQHDSKSINASPYHTPSHPGGGGGGSSGGTTEAGQQQQASANLMGNSSSSSSSNSSSNGSNSSSNSSNSLSALKASPRSSLSSSGIGSLKVRSESSLGAGGSCSLGSGGGSGGGVPMTPSIHSVFSSAHQTAMANNLASKRESILQMLQSLKRPSLFCKDYETLQGEDIPSTSQLLYDYTCVDAWMNHPVKRMRLAAEENRLVKKIRNLDLYANEHSRTMASGPGLAGSGNSTNGGIGTNGMLMKGAAEASEALAEALSGGRPGTGGGSDNGAPNNGAGCTPLLGQIKMEIGCDGSQAGAAVGSANGGTPDRNGASAGNGGAGDGALLGEHEIKKEKEDKGSIFLTDQDLQPSIDDLNQIFDDGGPFNDDPDLHNTPPGSNKSSSGSGGFSEESKRFPSSNHHSVNSGMLSPKELSQMFPTPPSLDPHPNSSPGGGGCLSDGGSIALDTLVDLQMSLSSGAGSGGGNGGGASSVPPIPNLGSPQEEPIDDWSFVFLPPPICPYVGSSKYAPLPSLPSQQVMPPIPTSTVAGLVYKSTRQKQKEQAAAEREKQKQREQAEREREREQKQEQQQDQPDGQPESGGQGGAGAGPGRPVGVAGPTTTALGVGLGLLPIVKQEVGGLTVPQPLSTPNSLLGGLSGLNGGSLAHPYSNPPSQGAQSQPHSRPPSVNSLPGGIMGGGAGMLSPSPAGTSGGGLFHPGGMGGIPVPLRQGMSPISPATPGGSMRVPTPQGSCPLPYPSPLGGAGSPNPMGSLSFRRTTPLLPPPPYDVAIASPANSVATPSSYHSKQYPLDGVDSGGPGSNRGPMTPSSTGGSGPLGAGTVHPPLSSSGVGCGTGTPAGSRSIETNALLVNVLLYDTALNIFRDHNFKSCTLCVCNAGAKCVGNIRGADSGLYLALPGTNWMDSVTAAGTEPTPSTTPGPAGGRSKASALAHLGLGGSSSAFGTGMLGSPAVGRQEDKMAAVTINTDSLQNGYLDEDPIDCQCGFSAVVNRRMAHRAGLFYEDEMEITGMAEDPAVHKNGSLFEFLNGTAKAIKLEDADRGTLATSAGGSSSSAAGGDSLPLTLKVMDLLREQCSVVQSSSNSIHRAVNRYRGPLFGRGAENGAVHLLEYVDANDVISLALEQGRLQAINESKMDVDQQQQQQQSSSGALVKGGTLRGQMNVHKWPFLRAGGPKSNQDIVRIMKSMQPLLQDAFHKRCTTRLWDAPYTIQGPLTWRQFHRLAGRGTGQCEPQPIPSLIVGYEKDWLSLAPYALHYWDKLLLEPYSYPRDVAYVAIVPDNDYVVAKVRTYFKELSTTYEMCKLGRHTPIKGWDGILRVGSQRVLKETQNSNLDEWFTNMGVDQQRKNGTTTAGSASSSSSSGLNELLRLYAQTCQQQLAPYLSKVPSDKSLLDPPESHHHTSSSASASASLGGGAAGASSLGGGSMGQPGGNAMGQNRPDGPGQSPMPPPPPSTPDSSQPGDKAPNTPKFDHDSENRDQLNTSSASPADGMRIDDDGKDPPHIVLYIVEPFTCGNDSPDVERLACLSLLRCYSNILNAVPDSIRSNISVQIISLESILELGRNRNRLRLSDHMRCLALSVFSQSRKYLAHMNTVKSLTGFGTAANAEQFIKRKDDKNRVPYRLYTPPYVLARSCEKSENTESFGKTSMKQQCSIMYCSYCLSEDQSWLLAVATDDRGEFLETVTINIDIPNRGRRKRASARRYGLQKLMDFILGLISQTVQPWRLVVGRIGRIGHGELKGWSWLLSKPNLQRASKHLKDICEQCSLMHPIAVPSILSACLVTLEPDSDLRVMSDQFTPDERFSQRSMQSPLSTPQDATCTHILVFPTSAKAQSAQASFSVIGELDLGEDLNMVIMDGDDDDDGINMMDVFKCWDDLPMQQINMPHSRPGSPSQFEGNQQSPGESGSKGAGSRDGYGSQDSEEVGLVLQQPLAIGYLVSTAPTGRMPEWFWSSCPHMENVCPVFLRTALHLHSPTILQNTDDPLQQNQSSTEHPLDSNITADVLRYVLEGYNLLSWLAMDSNTHDRLSCLPIHVQVLMQLYHMTAALA
Length2977
PositionMiddle
OrganismAnopheles arabiensis (Mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.05
Grand average of hydropathy-0.460
Instability index53.77
Isoelectric point6.07
Molecular weight310947.39
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20898
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     635.65|      93|      94|     445|     537|       1
---------------------------------------------------------------------------
  445-  519 (101.10/26.08)	...............................TAGS.SSSNAAAA...AA.......S.....SARPKDTA...NDAAAPSPTGTLRQRNHH..........................KS...........MMTP................PLTVP.ESPSND.........LGNPLSM..SSALINK.SPA
  587-  646 (48.87/ 8.29)	..............NSSS.............GGGD.ENSSGAAN...G.......................................................................vdangnssvweISDP................TVKVS.CCCIKC.........CKRPPSS..SSSSSSS.SAS
  683-  772 (49.72/ 8.58)	...............SSP.............GGGG.......AA...AA.......GgggslHPHPKSSY...SITYPGSSSGSSRSSHYHhhqstkdhhhhhhhhhhhrpqrvafhK..............RP................PQEAL.FRPGTE............PLSL..SAA........
  773-  869 (100.32/25.82)	AALAAAAAAAAANAASSP.............GAVS.SGDSAADSlelAD.......T.....CLRSNQ......NCAASSGGGGGNSGASN..........................TT...........GAAP................GSTTPyGGPPSY.........CRNPMSIgdSHPLPSEgSPA
  875-  968 (102.66/26.61)	PMQPSSVSQP....TSVP.........sgdqLITM.SPHPPASN...NP.......R.....SVQPGTPCldhLDKNTPAPTPT..DQHDS..........................KS...........INAS................PYHTP.SHPGGG.........GGGSSGG..TTEAGQQ.QQA
 1358- 1439 (86.23/21.02)	.............PNSSP.............GGGG.CLSDGGSI...AL.......D.....TLVDLQMS...LSSGAGSGGG..NGGG.............................A...........SSVP................PIPNL.GSPQEEpiddwsfvfL..PPPI..CPYVGSS.KYA
 1499- 1582 (60.46/12.24)	........QQQDQPDGQP.............ESGG.QG..GAGA...GPgrpvgvaG........PTTTA...LGVGLG.......................................................llpivkqevggltvpqPLSTP.NSLLGG.........LSGLNGG..SLAHPYS.NP.
 1583- 1682 (86.28/21.04)	...PS..QGAQSQPHSRPpsvnslpggimggGAGMlSPSPAGTS...GG.......G.....LFHPG......GMGGIPVP...LRQGMSP..........................IS...........PATP...ggsmrvptpqgscPLPYP..SPLGG.........AGSPNPM..GS.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.11|      14|      24|    1306|    1328|       2
---------------------------------------------------------------------------
 1309- 1322 (24.07/ 6.52)	SNKSSSGSGGFS..EE
 1329- 1344 (20.04/ 9.35)	SNHHSVNSGMLSpkEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.05|      19|      24|     995|    1017|       3
---------------------------------------------------------------------------
  372-  390 (33.42/11.92)	SAGDA.RSNSSSSS...S....SSNSS
 1000- 1026 (15.63/11.35)	SALKAsPRSSLSSSgigSlkvrSESSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     148.66|      28|      28|     258|     285|       4
---------------------------------------------------------------------------
  240-  265 (33.35/10.22)	..APGAAAATASTTGGPA..spDG....GLNG.........AP
  266-  296 (30.61/ 8.56)	GCAPGSPGGSSNSAVVPADD............aieprevllAP
 1152- 1180 (28.06/ 7.00)	..GPGLAGSGNSTNGGIGTN...GmlmkGAAE.........AS
 1189- 1203 (29.64/ 7.97)	GGRPGTGGGS........DN...........G.........AP
 2355- 2378 (27.00/ 6.35)	..SMGQPGGNAMGQNRP.....DG...pGQSP.........MP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.49|      26|      61|    1861|    1886|       5
---------------------------------------------------------------------------
 1861- 1886 (49.94/22.44)	LAH.LGLGGSSSAFGTGMLGSPAVGRQ
 1924- 1950 (38.55/15.40)	MAHrAGLFYEDEMEITGMAEDPAVHKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.88|      28|    1648|      79|     106|       6
---------------------------------------------------------------------------
   79-  106 (55.84/22.42)	PEPDPSSMFDMSIPGTGNSGS.VVHPPLS
 1729- 1757 (51.05/19.81)	PGSNRGPMTPSSTGGSGPLGAgTVHPPLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.22|      14|      14|    1033|    1046|       7
---------------------------------------------------------------------------
 1033- 1046 (25.73/11.68)	SLGSGGGSGGGVPM
 1049- 1062 (24.49/10.69)	SIHSVFSSAHQTAM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.23|      23|     974|     303|     325|       8
---------------------------------------------------------------------------
  303-  325 (42.77/25.91)	LTGQSYRASDPHTQKILDDWSAF
 1274- 1296 (42.47/25.68)	LTDQDLQPSIDDLNQIFDDGGPF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.52|      10|      15|    1119|    1128|       9
---------------------------------------------------------------------------
 1119- 1128 (15.85/10.49)	VKRMRLAAEE
 1135- 1144 (16.67/11.45)	IRNLDLYANE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.65|      23|     334|    2058|    2080|      12
---------------------------------------------------------------------------
 2058- 2080 (41.98/21.28)	QAINESKMDVDQQQQQQQSSSGA
 2393- 2415 (39.68/19.74)	KAPNTPKFDHDSENRDQLNTSSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.63|      35|     500|    2417|    2458|      14
---------------------------------------------------------------------------
 2417- 2458 (53.30/54.99)	PADGmRIDDDgkdpphIVLYIVEPFT....CGNDSPDVERLACLSL
 2923- 2961 (57.33/36.90)	PLDS.NITAD......VLRYVLEGYNllswLAMDSNTHDRLSCLPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.16|      12|      23|    1221|    1232|      16
---------------------------------------------------------------------------
 1221- 1232 (22.89/ 9.28)	GCDGSQAGAAVG
 1247- 1258 (22.27/ 8.80)	GNGGAGDGALLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.74|      14|      15|     969|     982|      18
---------------------------------------------------------------------------
  969-  982 (25.82/ 9.71)	SANLMGNSSSSSSS
  985-  998 (24.92/ 9.09)	SSNGSNSSSNSSNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      54.77|      11|     237|    1259|    1269|      23
---------------------------------------------------------------------------
 1259- 1269 (18.56/13.68)	EHEIKKEKEDK
 1477- 1487 (19.81/15.14)	EREKQKQREQA
 1488- 1496 (16.40/11.16)	ERE..REREQK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20898 with Med13 domain of Kingdom Metazoa
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