<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20891

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSTTHISLEPPAITAQDGLDDDLFVPAARLYEVTHDGQQVLTRQVGEDPNKPPTERLLRIWQERGDFSQLTTRRMRDEQGKDLTKSSTDEHSGEQDEDKDDVHELGITPEQMSELRMTMMQQLDLARGELTTALDLLSIIAAPTVATTVDAEGLPLPQQTLTIVPSAPPIPLPSSENDDSANEHTGASTSLLPLATSVASLRESANSFFSVSSQVLASTSNSTTSTSTSSSRNPTSKQWSTLLHLHTSTPFPLIPLGARSNASFSGQGETRLAKQVGVFYGCAEAAPSFRRAGVAQVEQVLQEVEKGSEGTGKGVGRKRGRKLVVEVEMEGRGRDWCVWTSGAAEKEGKEQGVEDVLKQRGRNVFAEELFAVLSNEARSDASVKSRLELGKRSQGDSVITEGHGWKLKITMVADPNPKLEAPTPEPNAIAPLLVPLLRLLLIQEYIRRRSPTSFSASIPILPTVSAFLSHLYRLNSLCGVLTTLTSTIDPSIATSITYHPSLASAPLSAVRKILSPLTTSTELKELGGRIVLRIGSSPTSLFYISHSTLLPQPSSTSPTNPSTNPSPSMGMSAFTLASHQGLVLQAPRSAPVVVGSVGQLKGFLQEQIGEVLKGYAGREEVEEVNGKEKEGMET
Length634
PositionHead
OrganismMicrobotryum saponariae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Microbotryomycetes> Microbotryales> Microbotryaceae> Microbotryum.
Aromaticity0.04
Grand average of hydropathy-0.321
Instability index47.47
Isoelectric point5.49
Molecular weight68240.07
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364140

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20891
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.40|      26|      27|     165|     190|       1
---------------------------------------------------------------------------
  165-  181 (23.96/ 8.59)	...........PSAPPI.PLPSSEND.DSA
  182-  211 (28.88/11.87)	NEHTGASTSllPLATSVaSLRESANSfFSV
  212-  237 (39.57/19.02)	SSQVLASTS..NSTTST.STSSSRNP.TSK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      98.54|      26|      26|     310|     335|       2
---------------------------------------------------------------------------
  274-  311 (19.06/ 8.72)	.KQVGvfygcaeaapsfRRAGVAQVEQVlqEVE.KGSEGT
  312-  337 (47.91/32.39)	GKGVG............RKRGRKLVVEV..EMEGRGRDWC
  340-  363 (31.57/18.99)	TSGAA............EKEGKEQGVED..VLKQRGRN..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.57|      26|      32|     454|     485|       3
---------------------------------------------------------------------------
  454-  485 (38.39/38.28)	FSASIPILPTV.SAFLSHLYRlnslcgVLTTLT
  492-  518 (40.18/24.90)	IATSITYHPSLaSAPLSAVRK......ILSPLT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.28|      24|      32|      39|      70|       4
---------------------------------------------------------------------------
   13-   37 (36.04/12.04)	ITAQDGlDDDLFVPAARLYEVTHD.G
   41-   65 (40.25/37.96)	LTRQVG.EDPNKPPTERLLRIWQErG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.01|      23|      32|     534|     558|       5
---------------------------------------------------------------------------
  534-  558 (36.00/25.05)	IGSSPTSLfyISHSTLLPQPSSTSP
  569-  591 (41.01/21.75)	MGMSAFTL..ASHQGLVLQAPRSAP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20891 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) SQLTTRRMRDEQGKDLTKSSTDEHSGEQDEDKDDVHELGITPEQMSELRMTMMQQLD
2) TTVDAEGLPLPQQTLTIVPSAPPIPLPSSENDDSANEHTGAST
68
147
124
189










Molecular Recognition Features






MoRF SequenceStartStop




1) TERLLRIWQER
54
64