<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20887

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMAPHPLPARPIQSVAGVATPSWPSLAQPPLSTGATMHQQAARSQAGTTGFSTTLPPPPSAVQPMPRLPPPRPPYSGPASAAAQQSSGQVYSQSQSQGQGGPLPLPALGAARSSSFQGNATSPNGSNTPGSLPASPKWGTPGQHLPQSHQQHHLATPTHTPNPASSSTPSFALPRAPSMRKALTSQDVRVNSVQVDLPGQGRWKVHWRAWRGPALLDTSVAAPPTPPSTTNVSDKALASHLGMPLHEHTPTAKYDPLTSTAPIPTTTLKRARSALCDDDPSTSIPIASTSSAPGSSLRARLQALQKVDPSQDPIELALKQVQRVAANLTASASNTVSSGVPSLFSYVRISAVRPIEDFKGKGKAKATEAQDAAVGRMLWVFGLSSDSIEHDPTREALSALEFADIICVGKGHFAHRDVFPAMYEMTTSPSSDAKTAPSQPASVALPLALPASAFPSVLSLSAQFHADLPCPASAPQPQTRICSPCEAFLAGCGSVIRQSLLAQEDGHSSSELRRPALPLGSAIVILPPASEPFGYSGRRILPEAIKTTLHLSLNLQGLLVRSAVEDVAYRPYPVLSATVTPVPTGAPVLLAPLGTPATFVRTVAPSSHSLHASRVNASLRQTWLNALDGSDLALDEHEHWLVCRISIPPHDTTANMSPQVSDSSPEHLDVMWPASLCLLDGTRSQPLRSPQSTPPRVKAVDLADSSSLDPFVHNTSEAGLSSPDVLTRQQLAAALHRGLAADALNPHKSSSSTTYHDPIRARVEQVGALLVDLQEQREQRLRLEREAEAVRASPAAAATTAPPASPPVAEPAKVASTAGAPISMRTPISLVGGSTEALSPGDAFSAAERSLMSALGEAPFASTDPATMQSSNASALTTTKNAEMDHLYPSPFEAPNALPIVSEGVGSDSVMNTVELGSSHDATFPNFDWGEDFSAGQNPGLRHNQDFDDGMMMDLNDDDFSFFDDPAPLPTSLPLGTLNGLQSAGPSPKFLDHFSHLGSGATPFPSVASPASPSLGVASPNVHTSPAVLSFSFDNNQSHNALGLGGATPRAQQLAEQSPFKTSRTPYTPYVEVVDEENEPEIAHSGTHATATVSVAGTPASNALALKKLTQFEAVPFGSSHAKADERYDPRKGKFGLPSPGWDRKELPMGKMSNASASGVPWLTAICDPRANAARQLKQKRTPFLAKKRPCTDGTSNPCARVQPRDRKWIRSTEADSDNPGEEDSEDDDMDGPIEPQHHDGDDLAATETGPSHRASENSFGSGLLILRDHLKRMLSTAGAKVDIIAPVPVATKATKAAEHALETTVGLMADQTLHNPDFRNRSAALKVRSKSSGANGESTESLNRDEMRGPDAVVPLSTASSIATRIVYNRLARVAPNPDPLPLSTLHAPTLLLRAQQTIMQLSASALDFWNPMGFEPLSGPKDVTAFAVFEELNTDTREAVATWLDDVSEGYQSSRLGRHELGHIAASGTFSGVENGLAALPAGALSRVKDDYKGMVERWTSRPRSAANHLVDAARTRKHVVIYLLDPSEASRTSASAAPSIIAALAHILKSRASTMSLVVYPLPLSTVSRWRSIASADSIAARLRRLAFAVYDTLLVSVSSLPAPVPETFPSSQIGRHPVLGPLTRLYQSPAITASPVRETSIEFALVWPPSSLEVLHRHRLFHVAYGCFRALAEGEHGPALEWIVISGIDEKGETWKSVPQIVRYPPQMQLEEARARQVWKAAKSLHDTADIEWRVVVTKLGNMSKEEIIAWDKISREIIGGLRRPLHITISCAEIGPALSLLPVLHEASEHTSSPMSEEGELGAGNDAGTTMSPALGRSHAGRTRNQNKPIHLDSGTCLFVHTPNHPITFDTSASLVAPASSFLIHAPRLPTFAQAPFQPFMPASPAISVLALHVLSSACTKTSTLRIDLSQHVADIMQSFADLAALGHARWGASGRVPWHLEAVASVLDILAALT
Length1959
PositionKinase
OrganismMicrobotryum saponariae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Microbotryomycetes> Microbotryales> Microbotryaceae> Microbotryum.
Aromaticity0.05
Grand average of hydropathy-0.245
Instability index56.36
Isoelectric point6.36
Molecular weight207755.47
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20887
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     476.53|     137|     161|    1320|    1460|       1
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  269-  335 (57.08/19.40)	........RARSALCDDDPSTSI.......PIASTSSAPGSSLRARL.......QALQKVDPSQDPIELALKQvqrvAANLTASASN...TV..............................................................
 1320- 1460 (222.02/105.17)	NRSAALKVRSKSSGANGESTESLNRDEMRGPDAVVPLSTASSIATRIV.Y....NRLARVAPNPDPLPLSTLH....APTLLLRAQQ...TIMQLSASALDFWNPM.GFEPLSGPKDVTAFAVFEELNTdtreAVATWLDDVSEGYQSSRLGRH
 1476- 1619 (197.43/87.29)	NGLAALPAGALSR.VKDDYKGMVERWTSRPRSAANHLVDAARTRKHVViYlldpSEASRTSASAAPSIIAAL.....AHILKSRASTmslVVYPLPLSTVSRWRSIaSADSIAARLRRLAFAVYDTLLV....SVSSLPAPVPETFPSSQIGRH
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     892.48|     176|     179|     407|     585|       2
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   54-  167 (92.66/28.15)	.......................................................................LPPPPSAV........QPMPRLPPPRPPYSGPASAAAQQS...SGQVY.SQSQSQgqggPLPL..P.AL..G.AA....RSSsfqgnatS.....PN.......GSNTPGSLP.ASPKwgtPGQHLPQSHQqhhlatpTHTPN.PASSST...................
  407-  585 (279.98/110.04)	VGKGHFAHRDVFPAMYE.MTTSPSSDAKTAP......SQPASVALPL..ALPASAFPSVLSL..SAQFHADLPCPASAP........QPQTRICSPCEAFLAGCGSVIRQS...LLAQE.DGHSSS....ELRR..P.ALPLGSAIVILPPAS.......E.....PF.......GYSGRRILP.EAIK...TTLHLSLNLQ.......GLLVR.SAVEDVAYRPYPVlSATVTPVptGA
  594-  767 (195.06/69.83)	..........T.PATFV.RTVAPSSHSLHAS......RVNASLRQTWlnALDGSD....LAL..DEHEHW.LVCRISIPphdttanmSPQVSDSSP.EHL.....DVMWPA...SLCLL.DGTRSQ....PLRS..PqSTPPRVKAVDLADSS.....slD.....PFvhntseaGLSSPDVLTrQQLA...AALHRGLAAD.......ALNPH.KSSSSTTYHD.PI.RARVEQV..GA
  772-  938 (187.38/66.25)	LQEQR.EQRLRLEREAEaVRASPAAAATTAPpasppvAEPAKVASTA..GAPISMRTPISLV..GGSTEALSPGDAFSA........AERSLMSALGEAPFASTDPATMQS...SNASAlTTTKNA....EMDHlyP.S.PF.EAPNALPIVS.......E.....GV.......G.......S.DSVM...NTVELGSSHD.......ATFPNfDWGEDFSAGQNP.............
  940- 1068 (137.40/46.15)	.....LRHNQDFDDGMM.MDL..NDDDFSFF......DDPA..PLPT..SLPLGTLNGLQSAgpSPKFLDHFSHLGSGA........TPFPSVASPASPSLGVASPNVHTSpavLSFSF.DNNQSH....N.......ALGLGGA...TPRAQ.......QlaeqsPF.......KTSRTPYTP........................................................
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     404.14|      92|     931|     171|     263|       3
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  171-  263 (157.80/81.47)	ALPRAPSMRKALTSQDVRVNSVQVDLPG.QGRWKVHWRAWRGPALLD.TSVAAPPTPPSTTNVSD.KALASHLgMPLHEH......TP.TAKYDPLTSTAPIP
 1113- 1197 (132.00/63.84)	AVPFGSSHAKADERYDPRKG..KFGLPS.PG.....WDRKELP.MGK.MSNASASGVPWLTAICDpRANAAR..QLKQKR......TPfLAKKRPCTDGTSNP
 1200- 1289 (114.33/54.23)	RV..QPRDRKW.....IRSTEADSDNPGeEDSEDDDMDGPIEPQHHDgDDLAATETGPS.HRASE.NSFGSGL.LILRDHlkrmlsTA.GAKVD.IIAPVPV.
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.28|      27|     923|     365|     391|       4
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  365-  391 (48.36/36.70)	ATEAQDAAVGRMLWVFGLSSDSIEHDP
 1290- 1316 (45.93/34.40)	ATKATKAAEHALETTVGLMADQTLHNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      74.96|      16|    1755|      33|      48|       5
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   33-   48 (28.53/13.70)	GATMHQQAARSQAGTT
 1791- 1805 (18.48/ 6.11)	.ASEHTSSPMSEEGEL
 1812- 1827 (27.95/13.27)	GTTMSPALGRSHAGRT
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20887 with Med13 domain of Kingdom Fungi
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