<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20883

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMAPHPLPARPIQSVAGAATPSWPSLAQPPLSTGATTHQQAARNQAGTTGFSTTLPPPPSAVQPIPRLPMPPPPYSGPASAAAQQSLGQVYSQSQSQGQSGPLPLPALDAARSSSFQGNATSPNGSNTPGSLPASPKWGTSGQHLPQSHQQHHLATPTHTPNPASSSTPSFALPRAPSMRKALTSQDVRVNSVQVDLPGQGRWKVHWRAWRGPALLDTSVAAPPTPPSTTNVSDKALASHLGMPLHEHTPTAKYDPLASTAPTPTTTLKRARSALGDDDPSTSIPVASTSSAPGLSLRARLQGLQKVDPSQDPIELALKQVQRVAANLTASASNTVSSAVPSLFSYVRISAVRPIEDFKGKGKEKATEAQDAAVGRMLWVFGLSSDSIEHDPTREALSALEFADLICVGKGHFAHRDVFPAMYEMTTSPSTSDAKTAPSQPASVALPLALPASAFPSVLSLSAQFHADLPCPASAPQPQTRICSPCEAFLAGFGSVIRQSLLAQEDGHSSSELRRPALPLGSAIVILPPASEPFGYSGRRISPEAIKTTLHLSLNLQGLLVRSAVEDVAYRPYPVLSATVTPVPTGAPVLLAPLGTPATFIRTVASSSHSLHASRVDASLRQTWLNALGGLDLALDEHEHWLVCRILIPPHGTTANMSPQVSVSSPEHLDVMWPASLCLLDGTRSQPLRSPQSTPPRPKAVDLVDSLSLDPFVRTTFETGLSSPDVLTRQQLAAALHRGLAADAVNPHKSSSSTTYHDPIRARVEQVGTLFVELQEQQEQRLRLDREAEAVRASTVAAATTAPPASPPVAEPGKLNSTAAPISMRTPISLVGGSTEALSPGDAFSAAERSLMSALGEAPFASTDPATMQASNASALTTIKNAEMDHLYPSPFEAPNALPIVSEGVGSDSVMNTVELGSSHDATFPNFDWGEDFSAGQNPGLRHNQDFDDGMMMDLNDDDFSFFDDPAPLPTSLPLGTLAGLQSAGPSPKFLDHFSHLGSGATPFPSVASPASPSLGIASPNVHTSPAVLSFSFDNSQSHNALGLGGTTPRAQLAEQSPFKTPRTPYTPYVEVVDEENEPESAHSGTHATATVSVAGTPASTALALKKLTQFEAVPFGSSHAKADDRYDPRKGKFGLPSPGWDHKELPMGKMSNALASGVPWLTAMCDPRANAARQLKQKRTPSLAKKRPGTDGTSYPCARVQTRDRKWIRFTEVDSDNPGEEDSEDDDMDGPVEPQHHGGDDLVATETGPSHRAPENFFGSGLLILRDHLNRMLSTTGAKVDIIAPVPVATKATKAAEHALETTVGLMADQTLHNPDFRNRSAALKVRSKSSGAKGESTESLNGDEMRGPDAVVPLFTASSIATRIVYNLLTRVAPNPDPLPLSTLHAPTLLLRAQQTIMQLSTSALDFWNPMGFEPLSGPKDVTAFAVFEELNTDTREAVASWLDDVSEGYQSSRLGRHELGHIAASGTFSGVENGLAALPVGALSRVRDDYKGMANHLVDAARTRKHVVIYLLDPSEASRTSASAAPSIIAALAHILKSRASTMSLVVYPLPLSTVSRWRSIASADSIAARLRRLAFAVYDTLLVSVSSLPAPVPETFPSSQIGRHPVLGPLTRLYQSPAITASPVRETSIEFALVWPPSSLEVLHRHRLLHVAYGCFCAPAEGERGPALEWIVISGIDEKGETWKSVPQIVRYPPQMQLEEARARQVWKAAKSLHDTADIEWRVVVTKLGNMSKEEIIAWDKISRDIISALRRPLHITISCAEIGPALSMLPVLHEASEHTSSPMSEEGELGAGNDAGTTMSPALGRSHAGRTRNQSKPIHLDSGTCLFVHTPNHPITFDTSASLVAPASSFLIHAPRLPTFAQAPFQPFMPASPAISVLALHVLSSACTKTSTLRIDLSQHVADIMQSFADLAALGHARWGASGRVPWHLEAVASVLDILAALT
Length1947
PositionKinase
OrganismMicrobotryum silenes-dioicae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Microbotryomycetes> Microbotryales> Microbotryaceae> Microbotryum.
Aromaticity0.05
Grand average of hydropathy-0.210
Instability index53.94
Isoelectric point6.22
Molecular weight206545.41
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20883
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     139.82|      26|      27|     255|     280|       1
---------------------------------------------------------------------------
  121-  148 (34.38/12.14)	SPNGSNTPG..slPASPKWGTSGQHLPQS...H
  149-  179 (31.97/10.63)	QQHHLATPT..htPNPASSSTPSFALPRApsmR
  242-  271 (37.64/14.17)	MPLHEHTPTakydPLASTAPTPTTTLKRA...R
  272-  299 (35.83/13.04)	SALGDDDPS.tsiPVASTSSAPGLSL.RA...R
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     160.10|      31|      31|     657|     687|       2
---------------------------------------------------------------------------
  476-  512 (36.16/14.89)	QPQTRICSPcEAFlagfgSVIRQSLL...AQED.GHSSSEL
  514-  540 (36.82/15.32)	RPALPLGSA...I.....VILPPASE...PF...GYSGRRI
  541-  574 (32.60/12.62)	SPE.AIKTT.LHL.....SLNLQGLLvrsAVEDvAYRPYPV
  657-  687 (54.51/26.62)	SPQVSVSSP.EHL.....DVMWPASL...CLLD.GTRSQPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     103.73|      26|      33|       4|      29|       3
---------------------------------------------------------------------------
    4-   27 (41.40/15.26)	..........H..PLPARPIQSVAGAAT..PSWPSLAQ
   28-   62 (32.43/ 9.92)	P.PlstgattH..QQAARNQAGTTGFSTtlPPPPSAVQ
   63-   88 (29.90/ 8.42)	PiP........rlPMPPPPYSGPASAA....AQQSLGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     145.49|      31|      33|     834|     864|       4
---------------------------------------------------------------------------
  394-  419 (27.62/ 9.75)	.......EALSALEFADLICVGKGHFAHRDvfP
  425-  448 (30.37/11.53)	TTSPSTSDAKTAPSQPASVAL...PLA......
  834-  864 (51.74/25.44)	TEALSPGDAFSAAERSLMSALGEAPFASTD..P
  866-  891 (35.76/15.05)	TMQASNASALTTIKNAEMDHLYPSPF.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     379.11|     120|     143|    1440|    1566|       5
---------------------------------------------------------------------------
 1440- 1566 (178.98/115.78)	VASWLDDVSEGYQSSRLGRHE.LGHIaaSGTFSGveNGLAALPVGALSrVRDDYKGMANHLVDAARTRKHVVIY..LLDPSEASRTSAsAAPSIIAALAHILKSRASTMSLVVYP..LPLSTvSRWRSIASA
 1588- 1712 (200.13/108.33)	VSSLPAPVPETFPSSQIGRHPvLGPL..TRLYQS..PAITASPVRETS.IEFALVWPPSSLEVLHRHRLLHVAYgcFCAPAEGERGPA.LEWIVISGIDEKGETWKSVPQIVRYPpqMQLEE.ARARQVWKA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     202.76|      53|     140|     589|     641|       6
---------------------------------------------------------------------------
  589-  641 (90.51/46.17)	LLAPL..GTPATFIRTVASSSHSLHASRVDASLRQTWLNALGGLDLALDE.HEHWL
  731-  781 (66.20/31.46)	LAAALhrGLAADAVNPHKSSSSTTYHDPIRARVEQ.....VGTLFVELQEqQEQRL
  799-  832 (46.05/19.27)	TTAPP..ASP.....PVAEPG.KLNSTAAPISMR.TPISLVGG.............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     173.76|      46|     415|     964|    1009|       7
---------------------------------------------------------------------------
  964- 1008 (72.65/31.16)	........................DPAPLPTSLPL.GTLAGLQSAGPSPKFLDHFS..HLGSGATPFPSVAS
 1009- 1073 (49.68/18.88)	PaspslgiaspnvhtspavlsfsfDNSQSHNALGLgGTTPRAQLAEQSP.....FK..TPRTPYTPYVEVVD
 1078- 1127 (51.43/19.82)	P.................esahsgTHATATVSVA..GTPA...STALALKKLTQFEavPFGSSHAKADDRYD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     289.47|      92|     588|    1132|    1335|       9
---------------------------------------------------------------------------
 1237- 1335 (143.57/205.23)	HGGDDLVATETGPSHRAPenffGSGLLIlrdHLNRMLSTTGAKVDIIAPV.P.VATKATKAAEHALETTVGLMADQTLHNPDFRNRSAALKVRSKSS.GAKG
 1833- 1927 (145.90/48.47)	HTPNHPITFDTSASLVAP....ASSFLI...HAPRLPTFAQAPFQPFMPAsPaISVLALHVLSSACTKTSTLRIDLSQHVADIMQSFADLAALGHARwGASG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.97|      24|     833|     308|     342|      11
---------------------------------------------------------------------------
  308-  342 (32.75/35.68)	PSQDPIELALKQVqrvaanltasaSNTVSSAVPSL
 1138- 1161 (48.22/27.58)	PGWDHKELPMGKM...........SNALASGVPWL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.18|      18|     344|     102|     119|      14
---------------------------------------------------------------------------
  102-  119 (31.92/15.30)	LPLPALDAARSSSFQGNA
  449-  466 (31.26/14.82)	LPASAFPSVLSLSAQFHA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20883 with Med13 domain of Kingdom Fungi
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