<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20881

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSTTHISLEPPAITAQDGLDDDLFVPAARLYEVTHDGQQVLTRQDSNKLPTERLLRIWQERGDFSQLTSRRIRDEQNKDLTKTSSTDEHSGEQDEHKDDVHELGITPEQMSELRMTMMQQLELARGELTTALDLLSIIAAPTVATTVDAEALPLPQQTLTIVPSAPPIPLPSSENDDSTNEHTGASTSLLPLATSLASLRESANSFFSASSQVLASTSNSTTSTSTSPSRNPTSKQWSTLLHLHTSTPFPLIPLGARSNASFSGQGETRLAKQVGVFYGCAEAAPSFRRAGVAQVEQVLQEVEEGREGMGKGVGRKRGRKLVVEVEMEGRGRDWCVWTSGAAEKEGKEQGVEDVLKQRGRNVFAEELFAVLSNEARSDVSVKSRLELGKRSQGDSVITEGHGWKLKITMVAVPEPKLEAPIPEPNAIAPLLVPLLRLLLIQEYIRRRSPTSFSTSIPILPTVSAFLSYLYRLNSLCGVLTTLTSTIDPSIPTSTTYHPSLASAPLSAVRKILSPPTNSNELKELGGRIVLRIGSSPTSLFHISHSTLLPQPSSTSTTNPSTSPSPSMGVSAFALTSHQGLVLQAPRSAPVVVGSVGQLEGFLQEQIGEVLKGCAGREEVEEVNGKEKEGMEVDQSSLV
Length638
PositionHead
OrganismMicrobotryum silenes-dioicae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Microbotryomycetes> Microbotryales> Microbotryaceae> Microbotryum.
Aromaticity0.04
Grand average of hydropathy-0.306
Instability index50.94
Isoelectric point5.43
Molecular weight68869.77
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364140

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20881
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     111.52|      19|      21|     168|     186|       1
---------------------------------------------------------------------------
  168-  186 (31.49/15.60)	IPLPSSEND..DST.NEHTGAS
  190-  210 (23.05/ 9.38)	LPLATSLASlrESA.NSFFSAS
  230-  248 (24.27/10.28)	RN.PTSKQW..STLlHLHTSTP
  548-  564 (32.71/16.50)	LPQPSS..T..STT.NPSTSPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     169.34|      44|     330|     264|     307|       2
---------------------------------------------------------------------------
  264-  307 (76.78/40.90)	GQGETRLAKQVG.VFYG................CAEAAPSFRRAGVAQ.VEQVLQEVEEGRE
  312-  361 (34.97/15.48)	.........GVG.RKRGrklvvevemegrgrdwCVWTSGAAEKEGKEQgVEDVLK..QRGRN
  596-  631 (57.60/29.24)	GQLEGFLQEQIGeVLKG................CA.........GREE.VEEVNGKEKEGME
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     113.74|      36|     321|     113|     164|       5
---------------------------------------------------------------------------
  103-  144 (49.29/24.90)	LGITPEqmseLRMTMMQqlELARGELTTALDLLSIIAAPTVA
  435-  463 (40.88/16.50)	..........LRLLLIQ..EYIRRRSPTSFS.TSIPILPTVS
  494-  513 (23.57/20.59)	TTYHPS..............LASAPLSAVRKILS........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.71|      14|      32|     532|     547|       6
---------------------------------------------------------------------------
  532-  547 (19.68/16.28)	IGSSPTSLfhISHSTL
  567-  580 (25.04/12.96)	MGVSAFAL..TSHQGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.93|      13|      15|      43|      56|       7
---------------------------------------------------------------------------
   43-   56 (17.50/14.69)	RQDSNKLpTERLLR
   61-   73 (22.43/12.58)	RGDFSQL.TSRRIR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20881 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QLTSRRIRDEQNKDLTKTSSTDEHSGEQDEHKDDVHELGITPEQMSELRMTMMQQLE
2) TVDAEALPLPQQTLTIVPSAPPIPLPSSENDDSTNEHTGAST
66
146
122
187










Molecular Recognition Features






MoRF SequenceStartStop




1) RLLRIW
53
58