Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MSTNEPIGPQLTALLNQYQNLTLNLFSSLSTLSQLAPPTSTDPSSSTATTSPYSSNSSSSSNSLYTHLSTLSHEFQALLTLVHQHTAQRVLIHSLLSQLASLDQTWTDSLISLSCLESSLQPLINQGRLGRAQIDAASHAELLTCSNVLTYARRVAPFTSAPPSQDPTQSAFNSGASLLASTQQIATTSAGGGGRVFLPFPTEQAMRRGRLQLDMTGAAAGSKPGDDDDDDDDVGVVGEVGSVGMVNKAPIMKASTEPDPSKKLINQAKLDKEHRHHRPPQHGYNDDDFTFDLDLNPDM |
Length | 299 |
Position | Middle |
Organism | Microbotryum silenes-dioicae |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Microbotryomycetes> Microbotryales> Microbotryaceae> Microbotryum. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.388 |
Instability index | 42.68 |
Isoelectric point | 5.11 |
Molecular weight | 31972.02 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP20878 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 135.12| 31| 61| 199| 230| 2 --------------------------------------------------------------------------- 157- 191 (29.93/10.70) PFtsappsqdPTQSAFNSGASLLASTQQIATTSAG.... 199- 229 (53.90/26.89) PF........PTEQAMRRGRLQLDMTGAAAGSKPGDDDD 258- 287 (51.28/19.65) PD........PSKKLINQAKLDKEHRHHRP.PQHGYNDD --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 80.35| 25| 43| 51| 76| 4 --------------------------------------------------------------------------- 51- 76 (38.18/26.40) SPYSSNSSSSSNSLYThLSTLSHEFQ 97- 121 (42.18/24.27) SQLASLDQTWTDSLIS.LSCLESSLQ --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) FDLDL 2) PSKKLINQAKLDKEHRHHRPP | 291 260 | 295 280 |
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