<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20871

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDPVVSSNGGGPSLQDHGHGHRPSSNLAGYSSLSSSSSPSLSLSSSAQPLPSPPQGTDCTHTAATIPSLKLNHASSQSQPVPDHEPRSLDDELPTVTHDLIPLSHIVQRLVAQVHADLLNLTETLPSSSDPARKRAIVDYVLQTRRQLLKLLVLVRWSSQADALHKCMNIIGFLARQNFEFDQSVQRLHEVKDVLAGARVRNYDLTSALTVLSTGHYPFLPSVIPEFFTQPLPLSDSTVLETLAEVDQILAYRLACLENLPRAMRTYWIKDGRVAFRVERMWEATFTYGGERGKEEWYLLGIKYGFNVQDARGVWSSEPSGPIKETILQLCNQELARHPPTDPSSSSTPESAPLIRAYNFLQRLALSYQLEAIASQASVLAQTKWMGHLRCVREFDGRGLRVDYWLPKEGSNSTSANSGSGSAAAGGGAKTIPTATAPCLRFAYGQRDEVRGTERVELMRRRALDKLLIGGGTRGKRKEATTTGSQGPGSEPRQDETTEEQEDVDDALSITWTVPNSSDSAMPVDTTSVDLTLNESLDLEILLRRVTTRHVRSNMLELYDQLVHELDPNDLELVSSTNSNAPSIVDREEELQDEGVQQIKVHLYSSHYILVSLSTLSGKLEFKAVGEATSLREARLRGAAEKVDHSRRLLGETLLRIRATTILDEVDSKAGYLGLATTKRLPLKSNDLARFGSTTRGLLFIQLKGVSNGSSTGAQTASSFGWMSSGSSYYLVLVMNESGFRFALIGTREEADQMSAWTTIDEMGWIERGSMTGAGQQDPGTGFDVGIEDLRDLYAYCMKRIRFYIIESQLHLRRIPFQHVSPSAPASAPRTASLTPTSPYLVIHSSDLIASPTPIAHRNIAIHLLPPRSHSAHSNLGDAQQDQVAFLLKLKATLSPPPQNLSLATTHADPPTPNLLPSNVLYSPPTNLLEFRFDDLETCVQDFLDAYALVVKSVVMKRHRLLEIKRQDQAVSLVKAVMEAKLGGGGELASTTRTA
Length995
PositionTail
OrganismMicrobotryum silenes-dioicae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Microbotryomycetes> Microbotryales> Microbotryaceae> Microbotryum.
Aromaticity0.06
Grand average of hydropathy-0.306
Instability index51.25
Isoelectric point6.13
Molecular weight109188.97
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20871
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.08|      33|      57|     832|     867|       1
---------------------------------------------------------------------------
  832-  867 (50.19/32.63)	ASLTPTSPYLVIHSSDlIASPTP.IAHRNIAIHllPP
  892-  925 (54.89/27.39)	ATLSPPPQNLSLATTH.ADPPTPnLLPSNVLYS..PP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     164.39|      51|     296|     398|     449|       2
---------------------------------------------------------------------------
  398-  449 (87.61/58.24)	RG.LRVDYWLPKEGSnSTSANSGS..GSAAAGGGAKTIPTATAPCLRFA.YGQRDE
  696-  750 (76.78/46.20)	RGlLFIQLKGVSNGS.STGAQTASsfGWMSSGSSYYLVLVMNESGFRFAlIGTREE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.03|      12|      15|     470|     482|       3
---------------------------------------------------------------------------
  470-  482 (16.91/14.31)	GGGTRgKRKEATT
  487-  498 (23.12/13.92)	GPGSE.PRQDETT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.59|      20|      29|      39|      65|       4
---------------------------------------------------------------------------
   39-   58 (38.96/30.68)	PSLSL...SSSAQPLPS.PPQGTD
   67-   90 (28.63/ 8.22)	PSLKLnhaSSQSQPVPDhEPRSLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     144.43|      44|     694|     247|     291|       7
---------------------------------------------------------------------------
  247-  291 (76.89/54.41)	DQILAYRLACLENLPRAMRTYWIK..DGRVAFrVERMWEATFTYGGE
  942-  987 (67.54/42.91)	DFLDAYALVVKSVVMKRHRLLEIKrqDQAVSL.VKAVMEAKLGGGGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.22|      14|      16|     506|     519|       8
---------------------------------------------------------------------------
  506-  519 (25.37/15.93)	DALSITWTVPNSSD
  525-  538 (22.85/13.58)	DTTSVDLTLNESLD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20871 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGGTRGKRKEATTTGSQGPGSEPRQDETTEEQEDVDDALSITWTVPNSSDSAMPVDTTSV
2) MDPVVSSNGGGPSLQDHGHGHRPSSNLAGYSSLSSSSSPSLSLSSSAQPLPSPPQGTDCTHTAATIPSLKLNHASSQSQPVPDHEPRSLDDELPT
470
1
529
95










Molecular Recognition Features






MoRF SequenceStartStop




NANANA