Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MSTNEPIGPQLTALLNQYQNLTLNLFSSLSTLSQLAPPTSTDPSSSTRTSSTASSSSSNSLYTHLSTLSHEFQALLALVHQHTAQKVLIHSLLSQLASLDQTWTESLVALSGLESSLQPLINQGKLGRAQIDSASDAELLTCSNVLTYARRVAPFTSAPPSQDPTQSAFNSGASLLASTQQMAATSAGGGGGLFLPFPTEQAMRRGRLQLDMTGAAAGFKPGHDDDDDDDVGVVGEVGSVGMVNKAPTMKASTEPDASKKLINQAKLDKEHRHHRPPQHGYDDDDFTFDLDLNPDM |
Length | 296 |
Position | Middle |
Organism | Microbotryum saponariae |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Microbotryomycetes> Microbotryales> Microbotryaceae> Microbotryum. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.363 |
Instability index | 40.69 |
Isoelectric point | 5.03 |
Molecular weight | 31460.49 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP20862 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 108.30| 40| 77| 28| 101| 1 --------------------------------------------------------------------------- 14- 57 (63.47/55.78) LLNQYQNLTLnlfsSLSTLSQL.......................................APPTSTDPSSSTRTSSTASSSS 92- 174 (44.82/ 7.42) LLSQLASLDQtwteSLVALSGLesslqplinqgklgraqidsasdaelltcsnvltyarrvAPFTSAPPSQDPTQSAFNSGAS --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 40.88| 13| 139| 114| 126| 4 --------------------------------------------------------------------------- 114- 126 (23.82/15.96) ESSLQP.....LINQGKL 250- 267 (17.07/ 9.54) KASTEPdaskkLINQAKL --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) DASKKLINQAKLDKEHRHHRPPQHGY 2) DDFTFDLDLN | 256 284 | 281 293 |
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