Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MDDVLNTQFARVEKALTTLVDSIAAYNPAPQAAIDLFTADDELSEGLDQLAKHQANHVRIQLLRAEADALEEQLKNSVKKLAELRHDLFNTPVTTFPQDSRAVPFDELLQYATNISRYTVPPTYREPVPVPDKDKEEEDVASSSLPTNGLNTPAIVPETTDPANDGLQAQKEGGDADAPAPEVTPEEEEWLKKLKASNLPWYPWPNNDRIRAGNLYSLQYWREKGKDLDTFNIPAYMEEERLKALGQNVESKASPAKEPEEHRDRGAPRPAIKLGVFTGLDDMED |
Length | 285 |
Position | Middle |
Organism | Pyrenophora tritici-repentis |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Pyrenophora. |
Aromaticity | 0.07 |
Grand average of hydropathy | -0.743 |
Instability index | 50.44 |
Isoelectric point | 4.58 |
Molecular weight | 31843.95 |
Publications | PubMed=29685100 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP20860 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 55.60| 17| 23| 139| 160| 1 --------------------------------------------------------------------------- 127- 147 (24.47/ 6.83) PVPVPdkdkEEEDVASSSLPT 153- 169 (31.13/22.37) PAIVP....ETTDPANDGLQA --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 135.07| 43| 106| 66| 111| 2 --------------------------------------------------------------------------- 66- 111 (64.33/46.98) EADA.LEEQLKNSVKKLAELRHDlfNTPVTTFPQDSRaVPFDEL..LQY 175- 220 (70.74/41.43) DADApAPEVTPEEEEWLKKLKAS..NLPWYPWPNNDR.IRAGNLysLQY --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) EEEEWLKKLK 2) ELLQYATNISRYTV 3) IRAGNLYSLQYWR 4) KEPEEHRDRGAPRPAIKLGVFTGLDDMED 5) LPWYPW | 186 107 210 257 199 | 195 120 222 285 204 |
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