<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20858

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEFLKTCNTNAQSIGDFEAIAYQAFSIARTSTTPTLSRIRDWGSAEDIRAAEAELRKQLQLVAQDASRPWLWLFKPTTVDKAGQNNADLPDIDGYHLQREHAGCIKAIDLVRPPVRTGTPNTSTSSKPSSSSAAASHSGQGGSARPTQANSQPQTSADPPQSPDCFTIYELFTSSVIALISFHIVKDCNVVALNYRTFVSRASKRLENDQAEIKSPDVHRLTSITVHWTSSGTLLVSTFTDPKTVIRCLGHVSTPAEESQLAGRCIRVAPNGMLATISSFEDPIESVVDEIGVRHRKRTRLTSLEQNIEKWKSSVERWLGWKGYALPDLDKRTSWVRIRTAPSSLPASSPAAPSPDRDILWPRALCFFHVSQDHEITAAESSTSAGNHNMLRWFETPESAGFKDPLDAAQEWFLGKQDRDKLLEAQRKAKKAEEDAARRKEEQHNLYPSSPLNARAGAYGDLPAVSGVYPTPPDGVAPGAGISQSDTPSVSGTVSNVILAPGGSTPAINLSAPADTKMEDQQLPLTSPVIPPAPDNHNTSSGNDDLFEDMDEDGFGGDRINDTDFDFFDGPDNHDVDMLDAPALPDHNTAHTDAPHEPHHVTEPQVQDDMSDPFAALENALATASEPVVSEETDVKGKEPATAQASSFDVPETSEKKAVMPSSLVKVTFSKEPTPPLSPSAVFKALQPSPPYKSGSRTQQKRPSTSQHNTQFDPVAFSRKMSMSDAKYQDGRFSAHGHTEPAIKKTTPSPGPGTAPVQAKSLRDFPLLTKLRLAVGMASANKIPEIACLARAASEDLESSSDTSDASGEDSEEEEEIERTPVAILNSLVMPAKRKLQSEGNATPLSVTSFAESMGGDWQDLYALQLDEANLSTFEPSLFDWSLVNFPSPAERVATGARYSFPALLPSPSQMPDTPTSQPDLNYEVPEEKPLNGKDIISITQIVTDQIVSATLDVLGEDPLTENISEDSAAIEMHWQTAIKDVFPTAEDCDLPKLVGIHEVFQDYAALAKAQQRPPARKTDGPAITSSHMYQINPPHLRVRRADTHWDLLPPAVAFWEPLGLSPISSPKNIVSFCVYPHSDALRPCLENFLLNLQLAYDSCKLGSHSRVETVMEFEGGLVPVRATTASSPRETFKLLKDACIQLGRLLALQYAKIREQQDSNIDAFVIYMIDPFGGPSALWELCSAFWSLFQAYGQGPPGRPEQPQKPDLVLQVIPIKYIASFDAPVILDPSTYFNLAREVYDRCPPSAPSGDKTSLSIYSAPAFHLEETLPRNIPFKLVAEPAQDLLRENTYMHLGYAISLDGTWVTAAWTDSCGKSQAVVSYHLGTRMFREIAKEIWQNTIEILQSRRVNWRVCIAKAGVLEREELESWVFLISCPTQINVFVTLLTAVDADPPYQFTPTMSSSNQSNTAATANTPVSTPQAGVSPSDPGPGLTPAATPSADPSATDPAADPEARLVDITDETWGIVLAHRLHNSYSTTQFSPALISGLLVKRGETLQTRNNILHPIPDPETGPIVVAVNFLWIGASQHNRSSKPVPLQHINTAKPQSRPWTTGSWSEEYNKSHVDAYTADAHDG
Length1576
PositionKinase
OrganismPyrenophora tritici-repentis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Pyrenophora.
Aromaticity0.07
Grand average of hydropathy-0.409
Instability index58.31
Isoelectric point5.07
Molecular weight171907.16
Publications
PubMed=29685100

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20858
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     108.27|      25|      30|     612|     640|       1
---------------------------------------------------------------------------
  612-  640 (35.91/30.18)	DPFAALEnalaTASEPVVSEETDVK...GKEP
  646-  673 (33.89/18.68)	SSFDVPE....TSEKKAVMPSSLVKvtfSKEP
  681-  703 (38.47/22.42)	AVFKALQ.....PSPPYKSGSRT.Q...QKRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     143.29|      34|      34|    1417|    1450|       2
---------------------------------------------------------------------------
  463-  507 (40.11/14.35)	PaVSgvypTPPDG.VA...PGAGISQSDTPSVSgtvsnvilaPGGS..TPA
 1417- 1450 (64.63/27.37)	P.VS....TPQAG.VSPSDPGPGLTPAATPSAD.........PSAT..DPA
 1452- 1485 (38.55/13.52)	........DPEARlVDITDETWGIVLAHRLHNS.........YSTTqfSPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     114.90|      25|      29|     313|     337|       3
---------------------------------------------------------------------------
  313-  337 (47.37/23.61)	SSVERWLGW...KGYALPDLDKRTSWVR
  343-  363 (37.17/16.92)	SS....LPA...SSPAAPSPDRDILWPR
  388-  412 (30.35/12.45)	HNMLRWFETpesAGFKDP.LDAAQEW..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.17|      18|      30|     112|     130|       4
---------------------------------------------------------------------------
  112-  130 (29.09/17.12)	RPPVRTGTPNTStSSKPSS
  145-  162 (34.07/16.32)	RPTQANSQPQTS.ADPPQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.11|      15|      30|     984|     998|       5
---------------------------------------------------------------------------
  984-  998 (28.45/16.32)	PTAEDCDLPKLVGIH
 1014- 1028 (27.66/15.63)	PPARKTDGPAITSSH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.03|      12|      30|     509|     520|       6
---------------------------------------------------------------------------
  509-  520 (21.33/12.91)	NLSAPADTKMED
  538-  549 (21.69/13.27)	NTSSGNDDLFED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     124.80|      42|     196|    1046|    1093|       7
---------------------------------------------------------------------------
 1046- 1093 (69.40/48.04)	WDLlppAVAFW...EPLGLSPISSPKNI.VSFCVYPHSDALRpclENFLLNL
 1180- 1203 (27.49/ 8.34)	WEL...CSAFWslfQAYGQGPPGRPEQ.........................
 1271- 1295 (27.92/ 8.59)	........................PRNIpFKLVAEPAQDLLR...ENTYMHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.69|      23|      38|     220|     242|      16
---------------------------------------------------------------------------
  220-  242 (40.51/23.63)	RLTSITVHWTSSGTL.LVSTFTDP
  260-  283 (37.18/21.09)	QLAGRCIRVAPNGMLaTISSFEDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     136.25|      44|     372|     728|     776|      18
---------------------------------------------------------------------------
  728-  776 (67.80/48.01)	YQDGRFSAHGHTEPAIKkttpSPGpGTAPVQ...AKSLRD.FPLLTKLRLAVG
 1097- 1144 (68.45/35.67)	YDSCKLGSHSRVETVME....FEG.GLVPVRattASSPREtFKLLKDACIQLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.21|      26|    1480|      63|      88|      20
---------------------------------------------------------------------------
   63-   88 (49.07/29.25)	AQDASRPWL...W..LFKPTTVDKAGQNNAD
 1545- 1575 (41.15/23.24)	AKPQSRPWTtgsWseEYNKSHVDAYTADAHD
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20858 with Med13 domain of Kingdom Fungi
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