<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20846

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMESVVDEWKAFLSRCIASRIPPDVFAAAVAQLHAKSPLPGRKLAALVLLPRAAGIDPRSIAILEQLLALKKVDASDVLTVTFLHSKDRRPINTGDEKAPKDAQWSNPPELEEIIFHRLHKAFASEERPVNNTEGLRTLIVVTRWMQVMVTSHTSDTMIQAMAGIQQPHQQSINAREGLAMLVIGVIENPRILAILSNPKGKDVRKNFVQSLSSFIPFLHNNSAGSQTSLSLANRLEMSQKQHDFFEKLPNVNGERNESTGLEVAALQLDAVMELPQVNTRPGLYVFLNALLVARPLTDDFTIISHLHSRYKLEPQNMATDLITAAFDILANAMYRNEQSETLFYLKSFLINKVPILLTQLSGSIFPMTVEMCITQALSHVDPHAFPSFSQGFDDIMGSNNSLSDVRQDFLNACALHGLIAAGTVERLLGEAPMQGPPAKRYERKELLNQCKTNFDKISLYIDELENVDGNAGAIVAAVTDFIAHLCETQTTMYLKQLSCLIFRKPQAMDVMLQFTSPPSILRPLCQFLDDWHYDSDQGEHQPVYDEFGAILVCIMTFMYRYDLTYHDIGIGHDSFVAKLMQRGHHGMLPDELTEEQGKHLGNWLKGLYDSDKEGLSNEVFASCRPQEFYLTVPTLFRQTVVACSTGVLSFETVKGGLEYLGETFLLPSLIGGLTWMASYALLQTHNDLDAMIRIFNEVILSSPTSGDAQAMHSTIIAIVSSRLEKCFRTLQRREPNRTTLEPFIQAIKAHSHYERTAYATLKELDQWTNVPHSTLNTSLRHTVQQLSQWASTASLQPNPPSYTHRQIYASLKMLGATRTLRAIVEEVKNQTDAGNGAAALDIGISIICAPMVEDSPVSVDWVASQIVAPAPQRTRMNLREILKQEFDCAANLVATDPLTAETIVRLHRRVEAHFASLSETGLQAPPINIPSVHIGDMQSQTISDDLNRAIDDAAAASIVEDISNMDNKALQRSMDELTASEGLDLSSIGMGNGDSGTGDMGTDLGNLPDLDLGGGGDDDWGLDFDNM
Length1027
PositionTail
OrganismPyrenophora tritici-repentis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Pyrenophora.
Aromaticity0.07
Grand average of hydropathy-0.139
Instability index42.14
Isoelectric point5.22
Molecular weight113603.09
Publications
PubMed=29685100

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20846
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.53|      15|      17|     990|    1006|       1
---------------------------------------------------------------------------
  990- 1006 (25.18/18.56)	MGNGdsGTGDMGTDLGN
 1012- 1026 (30.35/16.11)	LGGG..GDDDWGLDFDN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.61|      12|      17|     655|     666|       2
---------------------------------------------------------------------------
  655-  666 (21.63/13.37)	GGLEYLGETFLL
  671-  682 (22.98/14.66)	GGLTWMASYALL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.43|      15|      17|     793|     807|       3
---------------------------------------------------------------------------
  793-  807 (28.95/17.96)	ASLQPNPPSYTHRQI
  809-  823 (24.47/14.03)	ASLKMLGATRTLRAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.01|      18|      19|     750|     767|       4
---------------------------------------------------------------------------
  750-  767 (33.46/23.07)	HSHYERTAYATLKELDQW
  772-  789 (32.56/22.26)	HSTLNTSLRHTVQQLSQW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     189.19|      69|     134|       4|      84|       5
---------------------------------------------------------------------------
    4-   84 (92.93/102.28)	VVDEWKAFLsrcIASRiPPDVFAAAVA...QLHAKSpLPGRK.LAALVllpraaGI..DPRSIAILEQLLAlKKVDASDV..LT..VTFLH
  140-  219 (96.26/67.36)	VVTRWMQVM...VTSH.TSDTMIQAMAgiqQPHQQS.INAREgLAMLV.....iGVieNPRILAILSNPKG.KDVRKNFVqsLSsfIPFLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.70|      10|      16|     841|     850|       6
---------------------------------------------------------------------------
  841-  850 (19.31/10.40)	DIGISIICAP
  860-  869 (19.39/10.47)	DWVASQIVAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.41|      13|      16|     934|     946|       7
---------------------------------------------------------------------------
  934-  946 (22.39/15.04)	IGDMQSQTISDDL
  950-  962 (20.02/12.66)	IDDAAAASIVEDI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.62|      14|      17|     353|     366|       9
---------------------------------------------------------------------------
  353-  366 (24.50/15.10)	VPILLTQ....LSGSIFP
  369-  386 (22.12/12.91)	VEMCITQalshVDPHAFP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20846 with Med5 domain of Kingdom Fungi
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