<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20839

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMIPHPSAGVQPWSRSMRAPNNGLGRVEAFQALSQSEPQSQKPPMPVPSSLPRQPAVIDLTTIPGDAQESEPPAKRLKLDVTSGAYAATGSPAPVSGGEARTTPGTATAKPQSLTWRGRPAWSFQALLSETTGAVEVQDDDATAQGKTSSSPPPLPLLPWKYTPQETPATDATKIAEIAPVKEVKTTPYRIEVPTIAPKIKGEKVADFSPWTGNHPEDILNEHTAKQGHYDRTQVSQNESNTARPSLYAQLKHRSGLQMLSSVFAAALEKRQSHNMVTAPSSFKPPPRVTLTDNKREAWLRDLANPSVPLRRLSRTIPHGIRGKVLLDQCLGKWIPVPRAIWLARCVGANEIRAFKRKGTSGALALGLESKWVRDWTATVQQFLDGVVGMCGAADWKVKMTYAVSLTSRLFFERLLDHDQYLSWFLLSLENASLNTIPVWLLMLGIYWNNIMRYRKRGRKLAEVLLEKLRQIKKSGHPDTLQPLVDRLSRCIRRLVLEHTSSLILPNSWMAYKELISSCLNFKETPDQTMFHNLVERNSRVQVLKSQQEAKARPPQQKVISLFDSLRSAHDVSATASACLDAVDDKTVLVSKLLEWAATPFRHGSRRVYTSVRLLRKWKMSGIDIESHILNFVAGFDSNSRLNMEHIYHIFSELVRSQTFSVGRYLQWLMAKGLAHSPASENEAISSELRLLIQLPSHRLPEHVRNLRNMLIDRAGFSLDQENSLVAKLQMSIAGRLPHIFGSERSGVLKTNLSLPAELTWAVKSEIGLWIRRGVAEHYRKPGRRYSNIPFLSDSGISALTPAEFCIIREILEGFGDLSMLADVLKQATTCDNSIVLASVADTVNYHFDTFCVISAVHDLFKGLVESYVRLKRFGAPSLDLIFSLIELGLRVPSEFNTVALLRQDLARIENRAAVAAPSPLSDHISVSTGQIDSLFQEKLDQTLLSGGGMDESTMDTSFASLTKALQDGHKKLSANEICRYMAYLRTFHPKRFDAMLVRWVCGLLKSQTRSTMARILPPLIGVGCVTIHAFVTLVKKLLQSEKVVAVIPSVAELKLDLFELLVPPKHDQSRLADMVTYRFRLAQQEFLAKHPEESLDIIRDAVPLIAPENTGAIYGPRRDDLTECATMLLQLLLTQNPERIVQSCLQKFIGQHTASTALLQKALDSLLGFDSDASDKTTPEAEKVIRMNNDFSLPFCQLKLQLLFNAEAAGQDNNSIVDVMFKAAVADTKSHNDHWYGLVSLMSHDAIQQIRERAERSFFSIPMFEENSDSLQSIETARLYLTMIEKLAPCIPEAGVPTVVPVLVEKMEFLLQKFVAMQANHTGAGDARPTNQASPSFERSLAFWFSALLRIVVIHRASFNTPGLAPRSHGLPEQTRLLISIFCISLARLPNRVLRLYPSADYFPQPKPVESYRPCPGILLQTHALDVAACLVDIFPDEARQQCARFLKEKCPPFLQFQNDARFLYLLGPIVDSSNPPQPASLPSPAAGGSTPTPSGSLAYGQQTPQQSSTAVPSGLSAGLSEGVNCIASHLRVQYRGRAIGAYPVRPWELLEDAAPIVGTNDTALSLKYFDARRVRA
Length1577
PositionKinase
OrganismAspergillus indologenus CBS 114.80
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.173
Instability index50.82
Isoelectric point9.05
Molecular weight175016.20
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20839
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.24|      34|     434|       8|      42|       1
---------------------------------------------------------------------------
    8-   42 (57.13/42.67)	GVQpWSRSMRAPNNG..LGRV..EAFQALSQS.EPQSQKP
  444-  482 (48.11/30.02)	GIY.WNNIMRYRKRGrkLAEVllEKLRQIKKSgHPDTLQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     411.23|     138|     308|     816|     964|       2
---------------------------------------------------------------------------
  816-  964 (204.42/172.15)	DLSMLADVLKQATTCDN..SIVLASVADTVNYHFDTFCVISAVHDLFKGL...........VESYVRLKRfgapslDliFSLIELGLRVPSEFNTVAlLRQD...LARIENRAAVAAPSPLSDHIS..VSTGQIDSLFQ..EKLDQTLLSGGGMDESTmDtSFASLTKA
 1120- 1277 (206.80/141.35)	DLTECATMLLQLLLTQNpeRIVQSCLQKFIGQHTASTALLQKALDSLLGFdsdasdkttpeAEKVIRMNN......D..FSLPFCQLKLQLLFNAEA.AGQDnnsIVDVMFKAAVADTKSHNDHWYglVSLMSHDAIQQirERAERSFFSIPMFEENS.D.SLQSIETA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     146.99|      33|      48|      43|      84|       3
---------------------------------------------------------------------------
   43-   77 (55.57/29.63)	PMPVPSSLPR.QPAVIdlTTIPGDAQ.ESEP.PAKRLK
   91-  124 (53.55/31.09)	PAPVSGGEARtTPGTA..TAKPQSLT.WRGR.PAWSFQ
 1469- 1498 (37.88/12.39)	PI.VDSSNPP.QPA.....SLPSPAAgGSTPtPSGSL.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     172.55|      56|     307|     231|     287|       4
---------------------------------------------------------------------------
  231-  287 (93.27/61.36)	RTQV..SQNESNtARP......SLYAQLKHRSGLQMLSSVFAAALEKRQ...SHNMVTAPSSFKPPPR
  539-  605 (79.29/47.37)	RVQVlkSQQEAK.ARPpqqkviSLFDSLRSAHDVSATASACLDAVDDKTvlvSKLLEWAATPFRHGSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     203.16|      69|     577|     724|     806|       5
---------------------------------------------------------------------------
  724-  806 (105.66/96.31)	LVAK....LQMSIAGRLPHI.FGSERsgvlKTNLSLPaeltwAVKSEIGLW...IRRGVAEH...YRKPG..RRYSNIPFLSDSGISAltpaeFCI
 1303- 1384 (97.50/60.09)	LVEKmeflLQKFVAMQANHTgAGDAR....PTNQASP.....SFERSLAFWfsaLLRIVVIHrasFNTPGlaPRSHGLPEQTRLLISI.....FCI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.04|      34|      40|     333|     370|       8
---------------------------------------------------------------------------
  333-  370 (48.87/48.55)	WIPVPRAIwLARCVGANEIRAFKRKGTsgaLALGLESK
  375-  408 (61.17/43.15)	WTATVQQF.LDGVVGMCGAADWKVKMT...YAVSLTSR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20839 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GEKVADFSPWTGNHPEDILNEHTAKQGHYDRTQVSQNESNTARPSLY
2) LLSETTGAVEVQDDDATAQGKTSSSPPPLPLLPWKYTPQETPATDATKIAEIAPV
3) MIPHPSAGVQPWSRSMRAPNNGLGRVEAFQALSQSEPQSQKPPMPVPSSLPRQPAVIDLTTIPGDAQESEPPAKRLKLDVTSGAYAATGSPAPVSGGEARTTPGTATAKPQSLTW
4) PPQPASLPSPAAGGSTPTPSGSLAYGQQTPQQSSTAVPS
201
126
1
1476
247
180
115
1514










Molecular Recognition Features






MoRF SequenceStartStop




1) AKRLKLDVT
2) LGRVEAFQALS
3) LPWKYTP
73
23
157
81
33
163