<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20837

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGSVTNIRVIDGFSQIYWRIYTEEPGITNIPGESPANGYTILKHLSRLKDLELRLRNLDCLVSSYPRRLCLWTFSSTPGFEALASVAASRSKDDTGRLLVGSTTLKVSSSGSVSSSDLVKNLSVEPQHVTSAAGPQRPSAPTPFVTIYASFISALMGTLSLQLIQQLGAVPLGSRTLLTLDERGLHETVGYSAESSTFAPALTTLQVQLISAGKLTVALQTVPQPGLLRLCNPEDYPESHDIPPGTDLWLSPSGSIARLVTTRPAQRVGSSPYPYNTGGIGSDRSDPVNRKQWMANVLGWLANFGLPVNGIDEDSWVEVEVWEPFYSRLAGETWRPNDGGLSTLPLKRILWPAIYCFRRTKSASSDSYGEMESVCAVIDNPLEFAEKWHVLEKPNLNETSPKPLPIAQESETKDHDAPTPDMAGLPEGLESLSRAAQYPDLQTAGLVYPTPPDGATTAGLNPTTVSSDAFSEDLYNSSAFPQQTRQISFGQPHSKDRSAMDVTMGFGPSAGLAVGSGLYDTNDDDDLFGDMNERDFGAKGITDADFSFFDEPGFDRMDEGDHPDPMHEMPDFTVTDQLEAQPTPAEHTFPGLMQEAVEDRMFEPEADTMDVTTEAQSEQPPHEKDVPLPSPQADNVGTISPPLSPVEVKKFLFPEPQAESHPSPQQGQMPGYYKPIHFKQGISSWDQKYSTEGKFWFKMRGKDTIENATTTSSDIPTIGLPRHTTTSKRSAGVKPSDEHGSPLDDIFQEATSDSELSYAASIDGAESEAESDLSPATYPTRKRKRSLSNSGTSLALSPEKTSINAEQDTATQRPEDSVFLGNFLSTFSDWSLTGYFSLSQNQTFPALLQKELQVQIAQILVDQITQSSLDHKYDGTVGLSGCGNEAHSPQSVDDESFMGGIERLDLNSFVSLQDPVALSPTTQARHSSQRKDTSKGTISRLGPPHLRVCRGKDFLETLPPAIPFWETFGLGPAHGQKDILAYCIHPHTATEAADTFLDRLGLVYSGCNLGNHDRGNRSNLFSRGMGSWDIDLSHTRYSSIMQSLKTICEDLGTALLQSPPGKDNNLVVYIVNPFAHAAALVDICSAFWSLFQRYVADADRQQARQLNELVLQIIPLDFLMSNESLVVPPQAEYLNLALEVYSRCPPKSPHSSLVNGAPPMLLAEPLPKIINFKLSSEKTSPLQEGRCLHIACSRSQDQRWMSVAWSDNTGALQRTMSYCLRFRNSSAARSIAEVRAEIWGATKDIMDRTQARWRVIVANTDPVDQEEVDTWTTLTEQYNKSRSANLELTILSVGTTPDLTLEPPFLPLPMSAVNPLASTTPIATPNPSISSPDQISTAPTPPSAANVPLNAPTPTDTNPEIESESLLMDICDETWGVVLSHRLNSSMHQTEYRPALASGYLLRRRGSTDGDGVYTMGANIIYTRRSSASYDAVLREILSMYRDLATLARARGTRAVQQGTLPWHIATVVKAQALLSYVL
Length1483
PositionKinase
OrganismAspergillus indologenus CBS 114.80
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.381
Instability index52.04
Isoelectric point4.92
Molecular weight162198.58
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20837
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     283.65|      47|      49|     586|     632|       1
---------------------------------------------------------------------------
  383-  426 (30.75/ 9.07)	.......................DNPL..efaekwhvlekPNL.NE..T...SP.KPLPIAQESETK.DHD...APTPDM
  427-  486 (38.88/13.45)	AglpegleSLSRAA..QYPDL.QTAGL...........vyPTP.PDgAT...TA.GLNPTTVSSDAF.SEDlynSSAFPQ
  563-  615 (55.67/22.49)	.........EGDHP..DPMHEmPDFTV......tdqleaqPTP.AE.HT...FP.GLMQEAVEDRMF.EPE...ADTMDV
  616-  665 (51.43/20.20)	T.......TEAQSE..QPPHE.KDVPL.............PSPqAD.NVgtiSP.PLSPVEVKKFLFpEPQ...AESH..
  666-  719 (41.19/14.69)	P.......SPQQGQ..MPGYY.K..PIhfkqgisswdqkySTE.GK.FW...FK.MRGKDTIEN.....AT...TTSSDI
  729-  769 (35.90/11.84)	T.......TSKRSAgvKPSDE.HGSPL...........................dDIFQEATSDSEL.SYA...ASIDGA
 1311- 1338 (29.82/ 8.56)	.........................PL.............PMS.AV.NP...LA.STTPIATPN.....PS...ISSPDQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     240.72|      76|     183|    1158|    1242|       2
---------------------------------------------------------------------------
 1158- 1242 (116.41/89.83)	VNGAPPMLLAEPLPkiINFKLSSEkTSPLQEGRCLHI.ACsrsqDQRW.........MSVAWSDNTGALqrTMSYCLRFRNSSAARSIAEVRAEI
 1339- 1424 (124.31/72.29)	ISTAPTPPSAANVP..LNAPTPTD.TNPEIESESLLMdIC....DETWgvvlshrlnSSMHQTEYRPAL..ASGYLLRRRGSTDGDGVYTMGANI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.67|      23|      55|     150|     172|       3
---------------------------------------------------------------------------
  150-  172 (38.78/25.29)	TIYASFISALMGTLSLQLIQQLG
  208-  230 (38.89/25.38)	TLQVQLISAGKLTVALQTVPQPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.27|      25|     814|     231|     264|       6
---------------------------------------------------------------------------
  232-  258 (46.73/28.45)	LRLCNPEDYPEShdIPPGTDLW....LSPS.G
  950-  979 (40.53/ 9.13)	LRVCRGKDFLET..LPPAIPFWetfgLGPAhG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.31|      28|      55|     291|     324|      12
---------------------------------------------------------------------------
  291-  324 (41.26/41.64)	PVNRKQWMAnvlgwLANFgLPVNGIDEDSWVEVE
  349-  376 (52.06/31.92)	PLKRILWPA.....IYCF.RRTKSASSDSYGEME
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20837 with Med13 domain of Kingdom Fungi
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