<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20829

Description Mediator of RNA polymerase II transcription subunit 4
SequenceMNTQVHTTLSTLESALQTLLTTLTTSPTASGAPAAALSLLAADDALTSTIDELRVHQRNYARLLGLRAEAQALEAKVRGIVREVVEYEGVVRGVCGDSSGSESDSDDEEDDTDLDSEGDGDGDGDGDGDTEMQGTEGSGAAKKKKTTTKLRGVKEVDYKLLLDFARRISKYNHQAAADAAAGVEERVAARRGSVKDAEMAGTGAGAGAGAGGANGAGDATATATATADAEPVAEVTKGATSWLDESAQLARQVYMLPYPMEDRIRMGLMGQIQLAAAEGRPGFQVEAEVERMIREAEGLGVAAPVAAAPGPEVAEQARHADEAARAAAAAGAGSSAAASAGTTTARPAAAPLPAKPKATLDLDLYDPDEDDE
Length372
PositionMiddle
OrganismAspergillus violaceofuscus CBS 115571
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.03
Grand average of hydropathy-0.368
Instability index28.31
Isoelectric point4.47
Molecular weight38025.28
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364141

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20829
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     121.57|      22|      22|     189|     210|       1
---------------------------------------------------------------------------
  165-  185 (32.83/15.69)	ARRIS.KYNHQAA.ADAAAGVEE
  189-  210 (35.37/17.62)	ARRGSVKDAEMAG.TGAGAGAGA
  212-  229 (26.53/10.92)	GANG....AGDAT.ATATATADA
  314-  334 (26.84/11.16)	AEQ..ARHADEAArAAAAAGAGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.80|      21|      28|     248|     275|       2
---------------------------------------------------------------------------
  248-  268 (38.11/41.40)	QLARQVYMLPYPMEDRIRM..GL
  277-  299 (30.68/15.43)	AEGRPGFQVEAEVERMIREaeGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.39|       9|      40|     302|     311|       4
---------------------------------------------------------------------------
  302-  311 (14.59/ 9.84)	AAPvAAAPGP
  345-  353 (18.80/ 8.47)	ARP.AAAPLP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20829 with Med4 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAAGVEERVAARRGSVKDAEMAGTGAGAGAGAGGANGAGDATATATATADAEPVAEVTKGATS
2) GLGVAAPVAAAPGPEVAEQARHADEAARAAAAAGAGSSAAASAGTTTARPAAAPLPAKPKATLDLDLYDPDEDDE
3) RGVCGDSSGSESDSDDEEDDTDLDSEGDGDGDGDGDGDTEMQGTEGSGAAKKKKTT
179
298
92
241
372
147










Molecular Recognition Features






MoRF SequenceStartStop




1) AARAAAAAGAGSSAAASAGTTTARPAAAPLPAKPKATLDLDLYDPDEDDE
323
372