<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20819

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGSVTNIRVIDGFSQIYWRIYTEEPGITNIPGESPANGYTILKHLSRLKDLELRLRNLNCLVSSYPRRLCLWTFSSTPGFEALASVAASRGKDDTGRLLVGSTTLKVSSSGSVSSSDLVKNLSVEPQHVTSAAGPQRPSAPTPFVTIYASFISALMGTLSLQLIQQLGAVPLGSRTLLTLDERGLHETVGYSAESSTFVPALTTLQVQLISAGKLTVALQTVPQPGLLRLCNPEDSPESHDIPPGTDLWLSPSGSIARLVTTRPAQRVGSSPYPYNTGGIGSDRSDPVNRKQWMANVLGWLANFGLPVNGIGEDSWVEVEVWEPFYSRLAGETWRPNDGGLSTLPLKRILWPAIYCFRRTKSASSDSYGEMESVCAVIDNPLEFAEKWHVLEKPNLNETSPKPLSIAQESETKDQDAPTPDMAGLPEGLESLSRPSQYPDLQTAGLVYPTPPDGATTAGLNPTTVSSDAFSEDLYNSSAFPQQTRQISFGQPHSKDRSAMDVTMGFGPSAGLAVGSGLYDTNDDDDLFGDMNERDFGAKGITDADFSFFDEPGFDRMDEGDHPDPMHEMPDFTVTDQLEAQPTPAEHTFPGLVQEAVEDQMFAPEADKVDVTTEAQSEQPLHEKNVPLPSPQEDNVGTISPPLSPVEVKKFLFPEPQAESHPSPQQGQMPGYYKPIHFKQGISSWDQKYSSEGKFWFKMRGKDTIENATTTSSDIPTIGLPRHTTTSKRSAGVKPSDEHGSPLDDIFQEATSDSELSDAASIDGAESEAESDLSPATYPTRKRKRSLSNSGTSLALSPEKTSINAEQDTATQRPEDSVFLGNFLSTFSDWSLTGYFSLSQNQTFPALLQKELQVQIAQILVDQITQSSLDHKYDGTVGLSGCGNEAHSSQSVDDESFMGGIERLDLNSFVSLQDPVALSPTTQARQSSQRKDTSKGTISRLGPPHLRVCRGKDFLETLPPAIPFWETFGLGPAHGQKDILAYCIHPHTATEAADTFLDRLGLVYSGCNLGNHDRGNSSNLFNRGMGSWDIDLSHTRYSSIMQSLQTICEDLGTALLQSPPGKDNNLVVYIVNPFAQAAALVDICSAFWSLFQRYVADADRQQARQLNELVLQIVPLDFLMSNESLVVPPQAEYLNLALEVYSRCPPKSPHSSLVNGAPPVLLAEPLPKIINFKLSSEKTSPLQEGRCLHIACSRSQDQRWMSVAWSDNTGALQRTMSYCLRFRNSSAVRSIAEVRGEIWGATKDIMDRTQARWRVIVANTDPVDQEEVDTLTEQYNKSRSANLELIILSVGTTPDLTLEPPFLPLPMSAVNPLASTTPIATPNPSISSPDQFSTAPTPPSAANVPLNAPTPTDTNPEIESESLLMDICDETWGVVLSHRLNSSMHQTEYRPALASGYLLRRRGSTDGDGVYTMGANIIYTRRSSASYDAVLREILSMYRDLATLARARGTRAVQQGTLPWHIATVVKAQALLSYVL
Length1480
PositionKinase
OrganismAspergillus violaceofuscus CBS 115571
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.371
Instability index53.01
Isoelectric point4.87
Molecular weight161527.70
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20819
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     183.20|      36|      55|     537|     572|       1
---------------------------------------------------------------------------
  527-  561 (58.20/32.03)	D...DDD.LF...GDMNE..................RDF.G..A..KGIT..DADFS.....FFDE.PGFDRM
  562-  579 (26.78/10.72)	D...EGD.HP...DPMHE................................................mPDFTVT
  580-  613 (34.48/15.94)	D...QLEaQP...TP..A.................EHTFpGlvQ..EAVE..DQMFA..........PEADKV
  614-  665 (34.40/15.88)	DvttEAQ.SE...QPLHEknvplpspqednvgtisP....P..L..SPVE..VKKF......LFPE.PQAESH
  669-  709 (29.35/12.46)	Q...QGQ.MPgyyKPIH...........................fkQGISswDQKYSsegkfWFKM.RGKDTI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     332.04|     112|     176|    1094|    1229|       2
---------------------------------------------------------------------------
 1094- 1229 (167.38/109.56)	LFQRYvadaDRQQARQLNELVLQI..VPlDFLMSNESLVVPPQAeyLNlalEVYSRCPPKSPHSSL.......VNGAPP....VLLAEPLPkiinfklssEKTSPLQEGRCLHI.ACsrsqDQRWmSVAWSD..NTGALQRTM......SYCLRFRNS
 1275- 1408 (164.66/71.24)	LTEQY....NKSRSANLELIILSVgtTP.DLTLEPPFLPLPMSA..VN...PLASTTPIATPNPSIsspdqfsTAPTPPsaanVPLNAPTP.........TDTNPEIESESLLMdIC....DETW.GVVLSHrlNSSMHQTEYrpalasGYLLRRRGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     213.01|      52|      55|     297|     350|       4
---------------------------------------------------------------------------
  253-  292 (44.23/18.32)	.......WLSPSG.........SIARLVTTRP..AQRVGSSP....YPyNTGGIGsdrSDPV
  297-  350 (87.27/50.93)	WMAnVLGWLANFGLPVNGIGEDSWVEVEVWEPFySRLAGETW....RP.NDGGLS...TLPL
  355-  408 (81.51/39.96)	WPA.IYCFRRTKSASSDSYGEMESVCAVIDNPL..EFA.EKWhvleKP.NLNETS...PKPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     238.41|      71|     544|     415|     505|       5
---------------------------------------------------------------------------
  415-  489 (114.45/65.57)	ETKDQDAPTPDmaGLPEGLESLSRPSQYPDLQTAGLVYPTPPDGATTAGLNPTTVSSDAFSEDLynSSAFPQQTR
  718-  756 (51.50/18.45)	.............................DIPTIGLPRHT.TTSKRSAGVKP....SDEHGSPL..DDIFQEATS
  757-  809 (72.46/28.74)	DSELSDAASID..GAESEAESDLSPATYPTRKRK....RSLSNSGTSLALSPEKTSINA................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.76|      29|     122|     882|     911|       7
---------------------------------------------------------------------------
  882-  911 (47.87/32.89)	GL..SGCGNEAHsSQSVDDESFMGGIERLDLN
 1005- 1035 (50.89/30.64)	GLvySGCNLGNH.DRGNSSNLFNRGMGSWDID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.07|      34|     891|      49|      82|       8
---------------------------------------------------------------------------
   49-   82 (61.03/38.53)	LSRLKDLELRLRNLNCLVSSYPRRLCLW.TFSSTP
  942-  976 (61.04/38.54)	ISRLGPPHLRVCRGKDFLETLPPAIPFWeTFGLGP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20819 with Med13 domain of Kingdom Fungi
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