<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20811

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMTSSEQWGIFLHRCLLHRIDAAEFKSLSRLLLQRCPITEALLLDVLLETRLSTGIKWDPLLPLYIDCLCKMGLVQTSTVLNALLKHSSIHDKHQSSSVEAYPGKKSRKCYTLMTDIRVIQDAMLSVSTGSVPKSFSEAISIFTAIIDWIQAVVAWNSSNIDSGDQSPGLISSPDTVSLFESLGILLAALSGTTKGLEVLSADSQEALKVKLGQALSAYLPICVEVSLPLRNRLDSLQKAFNLYGEPPAKPLDVSMMEGVNVNALQFEASVMDSPMINSRAGLFVYINAMLVGRPLVDDSMLLNYLSNRYGGHYEVLIEETITAAFDVLSNASYRSESNRSMFLFRSFLVNKLPAFFAAMLAASMVTLPMELCISHALGRLDPNTFPSFSQMFTMQSNTALSDVRQEFLFACASHKLIPESSIERLLGENPMQTLPVGGPYNKDDLVNQINANPERAEHLIGEIESMEGNAGAIVGAIIEVMHNLCNQKETMTLKNICNSLSRRPQAMDVILLFRSTKQVLQPLCSLLDAWHWDEDQGESQPVYDEFGSILLLVLAFTYRYGLRAQDLGLGGSNSFVLQILGSGSCSQKLDSLSDKQNKNLGGWITALFIAEGISEETMSACSPQEFYLLVATLFSQSLGACEAGKLEFDTLKGGSEYLLEPFLLPSLVLALNWLGNHIWETEGDPSIPLKALHSLINPTSISGEAKEIHRTVLNMTARRLEEQLKDVRARHPSRTDIKPILDALEPCLSFERSGSCHRSELDSWTSHAPGGLLGSIRSAFQSLVLWSASPHVSVAPHSYTHRQLVTGVLLLGATRVLGALVEELKLQTQTGSGDVALDIAATLICAPMAEYFAIDQNNHSHQPLDPTKEFFPRCPILTLRSALNLLHDNIPKISEKDPLRAEVIVRLYRRVNALMTPPAQVPNLDMNNIIQHMQLGVGGPGQMDLDPQGASGHGVTDDDAANLNRMLDNAAAAAAVGMDGGQTMGGMGLESSSGLDTSIDDVLNAADMAVGNPEFLDLDMEGLF
Length1024
PositionTail
OrganismAspergillus violaceofuscus CBS 115571
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.06
Grand average of hydropathy0.036
Instability index46.63
Isoelectric point5.05
Molecular weight111761.85
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20811
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.24|      39|      68|     325|     368|       1
---------------------------------------------------------------------------
  305-  347 (59.94/51.40)	LSNRYGGHYEVLIEET.ITAAFDV.LSNASYRSESNRsmflFRSF
  348-  388 (57.29/43.48)	LVNKLPAFFAAMLAASmVTLPMELcISHALGRLDPNT....FPSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     454.76|     193|     620|      11|     222|       2
---------------------------------------------------------------------------
   11-  134 (155.84/109.84)	..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LHRCLLHRIDAAEFKSLSRLLLQ...........................RCPI.TEALLLDVLLETRLSTGIKW....DPLLPLyiDCLCKMgLVQTSTVLNALLKHSSIHDKHQSSSVEAYPGKKSRkcYTLMTDIRVIQDAM...LSV.STGSVPKS
  135-  222 (53.10/57.19)	FSEAI.SIFTAIIDWIQAVVAWnssnidSGdqSPGLISSPDTVSLFESL.GILLAalsGTTKgleVLSADSQE.ALKVKLGQ...ALS.AYLPIC...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
  638-  759 (146.94/86.85)	...............................................................................................vevslplrnrldslqkafnlygeppakpldvsmmegvnvnalqfeasvmdspminsraglfvyinamlvgrplvddsmllnylsnrygghyevlieetitaafdvlsnasyrsesnrsmflfrsflvnklpaffaamlaasmvtlpmelcishalgrldpntfpsfsqmftmqsntalsdvrqeflfacashklipessierllgenpmqtlpvggpynkddlvnqinanperaehligeiesmegnagaivgaiievmhnlcnqketmtlknicnslsrrpqamdvillfrstkqvlqplcslldawhwdedqgesqpvydefgsilllvlaftyryglraqdlglggsnsfvlqilgsgscsqkldslsdkqnknlggwitalfiaegiseetmsacspqefyllvatlfsqsLGACEAGKLEFDTLKGGSEYLLE.............................PF.LLPSL..VLALNWLGNHI.WetegDPSIPL..KALHSL.INPTSISGEAKEIHRTVLNMTARRLEEQLKDVRAR..HPSRTDIKPILDALepcLSFeRSGSCHRS
  765-  899 (98.88/56.89)	TSHAPgGLLGSIRSAFQSLVLW......SA..SPHVSVAPHSYTHRQLVtGVLLL...GATR...VLGALVEElKLQTQTGSgdvALDiAATLIC......................................................................................................................................................................................................................................................................................................................................................................................................................................................apmaeyfaidqnnhshqpldptkeffpRCPIlTLRSALN.LLHDNIPKISEK....DPL..............................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.97|      10|      32|     423|     432|       3
---------------------------------------------------------------------------
  423-  432 (19.02/12.40)	ERLLGE.NPMQ
  457-  467 (13.95/ 6.94)	EHLIGEiESME
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.11|      14|     499|     434|     448|       4
---------------------------------------------------------------------------
  434-  448 (23.50/17.39)	LPVGGPyNKDDLVNQ
  935-  948 (26.62/14.26)	LGVGGP.GQMDLDPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.95|      30|      39|     951|     980|       6
---------------------------------------------------------------------------
  951-  980 (50.24/30.63)	SGHGVTDDDAANLNRMLDNAAAAAAVGMDG
  993- 1022 (50.71/30.98)	SGLDTSIDDVLNAADMAVGNPEFLDLDMEG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20811 with Med5 domain of Kingdom Fungi
Unable to open file!