<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20809

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVVMDTANIGRQIQGSPNDSQNGVSYSAGEKAPLKGSAVVQNGSLHAAGLEKGSVHRTDASTVTSLLAKTRELPELPHVTQGFFPFSILLNRSAQQCWNDLLDLITELAEIQVAPNDPGHASVPIVGKPPGNQSSENIQKKLRVLEFAHAKRADFIKLLVLSQWGRQAADVSKLIDIQNFIRTRHQAYTGALQWIGEMKKDLVRAQVANPDIRTSLEVLSKGRVASMLTLGYKPPKLLAPRRALRKLQKVNRLLCTRLALHDELPPSFQTYRIHDGRVTFIVPTEFELDLSIGEGSGLSQFFFVDIRFLFHPSSPIPKGRIFNELESKVNDVLQTRGLPGCFDLLHNLVLTNKINVLFKQATEMARGLWADVLRIELLHRTVVVHYWARKPGSKSWVEIGINSGRRGSMHGGSVPPYLGLRWIKYGEEVNSGLVDFDTANMSMERLLRSVIALHISHTVSSAYYSISQSLLYSTSTLSLRAQLTTTEPGNCLLDVQLTETRYLRVSVEPMSGANVFSTTPNVLERPDNDRLADKPAVDDIVTRVARLRCIAAIEEVECYLQMLGFDVINPRMLNIDIRRVFPANVLRISFFSHKSWEQNWVVAATSSMDGDNWWLVQLRPGVVPKRHSAFDVNLGSRPAFRLAQVVSNTFIFSRHEKSYMSLANLGHSLSGILTIYANSRCLADLDAIQSCPPAHKLRIEAGFQIPDISLRYEPAKLPNAIQLVLPAGIRQKGFIRETVRLTFLGIDSQTNLAIIGAYGRLNIPVKAFSALMSKWDRSLVFQESHNGFAIRLLAPTGRPVIISLVEDLQRLECVLSILDILQRKKIEVTSISLSGIFFTYGPRRDLAARLEVEVKRNPSLSEADAAELATRSDSIFRLQLGIRFDSTNPHRRIQGALASSLNRTSAEASIETIAELLTSTLPLMRALDHIMDNTSRNESLKVQVTVRNAMTYAIHYPDANLRFRLVARIRSNRLVWVLRNVSSSESSSDQVHSMSKVQQSLYDSKGEGWRGLGNGVIAQIDRVGNLLGELHRCIAASVPNTSLNKVGTRELSTITPTQATALSEVASGVATKAVRRDSSRPAHLQERTTQHSGSVASDTADVIMID
Length1108
PositionTail
OrganismAspergillus violaceofuscus CBS 115571
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.06
Grand average of hydropathy-0.119
Instability index45.11
Isoelectric point9.52
Molecular weight122881.56
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20809
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     214.67|      72|      92|     745|     822|       1
---------------------------------------------------------------------------
  745-  822 (108.41/79.51)	FLGIDSQTNLAiigayGRLNIPVKAFSALMSKwDRSLVFQESHNGFAIRL...LAPTG..RPVIISLVEDLQRLECVLSILDI
  839-  915 (106.26/62.53)	FFTYGPRRDLA.....ARLEVEVKRNPSLSEA.DAAELATRSDSIFRLQLgirFDSTNphRRIQGALASSLNRTSAEASIETI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     262.23|      77|     148|     512|     592|       3
---------------------------------------------------------------------------
  422-  456 (34.64/16.59)	..........................................LRWIKYGEEVNSGL....VDFDT.......ANMSME.RL..LRSVIALH....
  512-  590 (129.13/96.65)	MSGAN..VFSTTPNVLERPDN..D.RLADKPAVDdiVTRVARLRCIAAIEEVECYLQM..LGFDV.......INPRML.NID.IRRVFPANVLRI
  610-  701 (98.46/61.31)	MDGDNwwLVQLRPGVVPKRHSafDvNLGSRPAFR..LAQVVSNTFIFSRHE.KSYMSLanLGHSLsgiltiyANSRCLaDLDaIQSCPPAHKLRI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.21|      18|      19|      15|      33|       5
---------------------------------------------------------------------------
   15-   33 (29.17/23.64)	IQGSPNdSQNGVSYSAG.EK
   36-   54 (27.04/16.18)	LKGSAV.VQNGSLHAAGlEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.72|      14|     578|     146|     159|       8
---------------------------------------------------------------------------
  146-  159 (23.37/14.58)	VLEFAHAKRADFIK
  162-  175 (24.35/15.50)	VLSQWGRQAADVSK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20809 with Med14 domain of Kingdom Fungi
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