<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20807

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMIPHPSAGVQPWSRSMRAPNNGLGRVEAFQALSQSEPQSEKPPMPVPPSLPRQPAVIDLTTIPGDAQESEPPAKRLKLDVTSGVYAATGSPAPVSGGEARTTPGTATAKPQSLTWRGRPAWSFQALLSETTGAVEVKDDDATAQGKTSSSPPPLPLLPWKYTPQETPATDVTKIAEIAPVKEVKTTPYRIEVPTIAPKIKGEKVADFSPWTGNHPEDILNEHTAKQGHYDRTQVSQNESNTARPSLYAQLKHRSGLQMLSSVFAAALEKRQSHNMVTAPSSFKPPPRVTLTDNKREAWLRDLANPSVPLRRLSRTIPHGIRGKVLLDQCLGKWIPVPRAIWLARCVGANEIRAFKRKGTSGALALGLESKWVRDWTATVQQFLDGVVGICGAADWKVKMTYAVSLTSRLFFERLLDHDQYLSWFLLSLENASLNTIPVWLLMLGIYWNNIMRYRKRGRKLAEVLLEKLRQIKKSGHPEILQPLVDRLSRCIRRLVLEHTSSLILPNSWMTYKELISSCLNFNETPDQTMFHNLVERNSRVQLLKSQQEAKARPPQQKVISLFDSLRSAHDVSATASACLDAVTDKTVLVSKLLEWAATPFRHGSRRVYTSVRLLRKWKMSGIDIESHILNFVAGFDSNSRLNMEHIYHIFSELVRSQTFSVGRYLQWLMAKGLAHSPASEKEAISSELRLLIQLPSHRLPEHVRNLRNMLIDRAGFSLDQENSLVAKLQMSIAGRLPHIFGSERSGVLKTNLSLPAELTWAVKSEIGLWIRRGVAEHYRKPGRRYSNIPFFSDSGISALTPAEFCIIREILEGFGDLSMLADVLKQATTCDNSIVLASVADTVNYHFDTFCVISAVHDLFKGLVESYVRLKRFGAPSLDLIFSLMELGLRVPSEFNTVALLRQDLARIENRAAVAAPSPLSDHISVSTGQIDSLFQEKLDQTLLSGGGMDESTMDTSFASLTKALQDGHMKLSANEICRYMAYLRTFHPKRFDAMLVRWVCGLLKSQTRSTMARILPPLIGVGCVTIHAFVTLVKKLLQSEKVVAVIPSVAELKLDLFELLVPPKHDQSRLADMVTYRFRLAQQEFLAKHPEESLDIIRDAVPLIAPENTGAIYGPRRDDLTECATMLLQLLLTQNPERIVQSCLQKFIGQHTASTALLQKALDSLLGFDSDASDKTTPDAEKVIRMNNDFSLPFCQLKLQLLFNAEAAGQDNNSIVDVMFKAAVADTKSHNDHWYGLVSLMSHDAIQQIRERAERSFFSIPMFEENSDSLQSIETARLYLTMIEKLAPCIPEAGVPTVVPVLVEKMEFLLQKFVAMQANHTGAGDARPTNQASPSFERSLAFWFSALLRIVVIHRASFNTPGLAPRSHGLPEQTRLLISIFCISLARLPNRVLRLFPSADYFPQPKSVESYRPCPGILLQTHALDVAACLVDIFPDEARQQCARFLKEKCPPFLQFQNDARFLYLLGPIVDSSNPPQLTSLPSPAAGGSTPTPSGSLAYGQQTPQQSSTAVPSGLSAGLSEGVNCIASHLRVQYRGRAIGAYPVRPWELLEDAAPIVGMNDTALSLKYFDARRVRA
Length1577
PositionKinase
OrganismAspergillus violaceofuscus CBS 115571
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.158
Instability index50.45
Isoelectric point9.05
Molecular weight175212.66
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20807
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.34|      34|     434|       8|      42|       1
---------------------------------------------------------------------------
    8-   42 (56.75/43.47)	GVQpWSRSMRAPNNG..LGRV..EAFQALSQS.EPQSEKP
  444-  482 (47.60/30.39)	GIY.WNNIMRYRKRGrkLAEVllEKLRQIKKSgHPEILQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     154.86|      41|      48|      43|      83|       2
---------------------------------------------------------------------------
   43-   77 (55.82/28.60)	..........................PMPVPPS..LPR.QPAVIDLTTIPGDAQESEPPAKRLK
   78-  124 (55.77/28.57)	LDVTSG.............vyaatgsPAPVSGG..EARtTPGTA..TAKPQSLTWRGRPAWSFQ
  127-  184 (43.27/20.39)	LSETTGavevkdddataqgktsssppPLPLLPWkyTPQ.ETPATDVTKIAEIA.....PVKEVK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     411.91|     138|     307|     816|     964|       3
---------------------------------------------------------------------------
  816-  964 (205.10/192.83)	DLSMLADVLKQATTCDN..SIVLASVADTVNYHFDTFCVISAVHDLFKGL...........VESYVRLKRfgapslDliFSLMELGLRVPSEFNTVAlLRQD...LARIENRAAVAAPSPLSDHIS..VSTGQIDSLFQ..EKLDQTLLSGGGMDESTmDtSFASLTKA
 1120- 1277 (206.81/157.90)	DLTECATMLLQLLLTQNpeRIVQSCLQKFIGQHTASTALLQKALDSLLGFdsdasdkttpdAEKVIRMNN......D..FSLPFCQLKLQLLFNAEA.AGQDnnsIVDVMFKAAVADTKSHNDHWYglVSLMSHDAIQQirERAERSFFSIPMFEENS.D.SLQSIETA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.43|      43|      49|     576|     622|       4
---------------------------------------------------------------------------
  576-  622 (67.84/64.44)	SACLDAVT..DKTvlvSKL.LEWAATPFRHGSRRVYTSV.RLLrKWKMS.GI
  626-  673 (59.59/43.30)	SHILNFVAgfDSN...SRLnMEHIYHIFSELVRSQTFSVgRYL.QWLMAkGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.47|      20|     307|     231|     251|       5
---------------------------------------------------------------------------
  231-  251 (31.92/22.02)	RTQV..SQNESNtARP......SLYAQLK
  539-  566 (24.55/11.64)	RVQLlkSQQEAK.ARPpqqkviSLFDSLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.70|      35|      60|     675|     713|       6
---------------------------------------------------------------------------
  675-  713 (49.41/44.73)	HSPASEKEAIsseLRLLIQLPShRLPEHVRNLRNMLIDR
  738-  772 (60.28/39.85)	HIFGSERSGV...LKTNLSLPA.ELTWAVKSEIGLWIRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.55|      16|      16|    1481|    1496|       8
---------------------------------------------------------------------------
 1466- 1481 (26.68/14.08)	LLGPIVDSSNPPQLTS
 1482- 1497 (29.87/16.78)	LPSPAAGGSTPTPSGS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20807 with Med12 domain of Kingdom Fungi
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