<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20796

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMDSLVREWTHFLDRCIELRVRADLFDAAAVQLHITSPLPGRKIAALLLKPRTPAAVSFDPRVVVYAERLLALKKIDASDLLSSAFQYSKDRPARQGEEHDSKDPSPWQNPPELEEILFHRLHKAFSGERVERPTTNTEGFRTLCVVTAWMSAMVTSHTSDSMIQALAGIQQHPQQQSINVREALGMLVVGLIENAKVLQLLNKVELKEVRKQFAQALSTFIPFLSQTSIQIANRLEIYQKEHDFHDKSVPSANEDGSENAVAALQLEAVIEIPMINTRAGLYIFLHSLLVARPLTDDILITSYINSRYKMDAQTMATDLVTAAFDILANAMYRNEPSQTMDSLKSFLVNKIPLLLSQYASPMYAMNPELCITQALSHVDPNAFPAFSQGFDIMGSNNALSDVRQDFLNACALHGLIQTSTVERLLGETPMQGPPETKYVKQNLIAQCKENFERVYAYIEELENLDGNAGAIVGAVTEFISHLCETQMTMHLKNICNLLSKKSQALDTMLQFTSPVSILKPLCIFLDEWRYDGDQGEYQPVYDEFGAILILVMAFVHRYNLTHYDLGIEHNSFVAQLLESGYHSVPPNDLTEDQGKHLGSWLRDLYDSDKEGLSNEVFASCRPQDFYLIVPTLFSQTVMACSADVLSLESVKGGLEYLHETFLLPALVGGLTWMASHALLSGHQDLDVLMQMFGKLIRSTPTSGDAQAMHSTILCVVSPQLKKCFRTLKRRHPNRNDIEPLLQAIKGVKGNLHYERSVYSSIAELEQWTNASNSTLISSLRQTVQQLSQWASSSALQPNPPSYTHRQIYTCIELVGASKTLRAIVDEIKAQTEAGNGAAALDIGVSIICAPMVDNSTMPVIWPGSSIPASPSPRTRINLREALQVEFDDAPSIVSADPLAAETIVRLHRRVEGLFADLAQAAGIPTGNAMLSTVNLADVPSQDLPADLDKAMNDAAAGVLATGNGDLSSMEGIDMELNKQGLNRTMDDLDLTAAGVDLSSIGVGTGGMSADIQMGDLPDLNLDDMGDMGDMGMGADGDDWGLDFTDM
Length1046
PositionTail
OrganismPericonia macrospinosa
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Massarineae> Periconiaceae> Periconia.
Aromaticity0.07
Grand average of hydropathy-0.100
Instability index41.43
Isoelectric point4.90
Molecular weight115105.79
Publications
PubMed=29679020

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20796
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.71|      25|      33|     913|     937|       1
---------------------------------------------------------------------------
  913-  937 (43.05/26.08)	L...FADL.AQ.....AAGI.PTGNAMLSTVNL.AD
  943-  973 (32.53/17.88)	L...PADL.DKamndaAAGVlATGNGDLSSMEG.ID
  981- 1010 (26.13/12.88)	LnrtMDDLdLT.....AAGV.DLSSIGVGTGGMsAD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      90.46|      21|      51|     164|     184|       4
---------------------------------------------------------------------------
  164-  184 (35.06/24.79)	QALAGIQQHPQQQSINVREAL
  215-  235 (35.30/25.02)	QALSTFIPFLSQTSIQIANRL
  503-  517 (20.10/10.83)	QALDTMLQFTSPVSI......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.63|      11|      50|     652|     662|       6
---------------------------------------------------------------------------
  652-  662 (20.31/11.99)	GGLEYLHETFL
  668-  678 (21.33/12.95)	GGLTWMASHAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.58|      11|      19|    1014|    1024|       7
---------------------------------------------------------------------------
 1014- 1024 (21.23/11.50)	GDLPDLNLDDM
 1036- 1046 (23.35/13.36)	GDDWGLDFTDM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.95|      10|      19|     381|     390|       8
---------------------------------------------------------------------------
  381-  390 (19.32/10.96)	NAFPAFSQGF
  397-  406 (17.63/ 9.40)	NALSDVRQDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.94|      20|      23|     564|     583|      16
---------------------------------------------------------------------------
  564-  583 (33.87/23.81)	DLGIEHNSFVAQLLESGYHS
  588-  607 (34.07/24.00)	DLTEDQGKHLGSWLRDLYDS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20796 with Med5 domain of Kingdom Fungi
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