<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20795

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSQSAKRQRTSYSPASPPYHIAAKPSETKTLIVQPNPPPSPPYPSMNSQSNGGFSSSAIGPPSVMTPPASVVMSQQYSPSGLTAGNPPTTFTPASTAGPSNSMHIDSDGDAMMLDTQDSDAAIRLGGRRRTDHNRQPRNIFAPDGGVAAAKGICGSQLFLGCQSSKPSRPHASQDLFELYKLGPLARSVARTNPVTGEKTNKLRKSYEGQIKKMQIAGKHKAVKMDGKFTGLMSLPEEEYYATVVSDKDVSKVGLNSQGTGLNTSLGDLVNRALGGIGPGGLSHSEMIKHRQYIGTDDTAKPKPNLEPTPHRATPSASGTPNTHTPISRISRPERTGSKRQYTDGSYSGYGEGYADDFADSTGGEDNAQGNFAKRRKMGLEQRSRQVEVGGVRR
Length394
PositionHead
OrganismPericonia macrospinosa
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Massarineae> Periconiaceae> Periconia.
Aromaticity0.05
Grand average of hydropathy-0.777
Instability index61.65
Isoelectric point9.66
Molecular weight41961.31
Publications
PubMed=29679020

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP20795
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.69|      22|      23|      37|      58|       1
---------------------------------------------------------------------------
   14-   34 (27.93/10.62)	.PA..SPPYHIAAKPSETKTLIVQ
   37-   58 (42.34/19.79)	PPP..SPPYPSMNSQSNGGFSSSA
   61-   84 (31.42/12.84)	PPSvmTPPASVVMSQQYSPSGLTA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.18|      25|     234|      88|     138|       2
---------------------------------------------------------------------------
   91-  119 (39.56/61.48)	FTPASTAGPSNSMHidsdGDAMMLDTQDS
  141-  165 (44.62/12.70)	FAPDGGVAAAKGIC....GSQLFLGCQSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.07|      19|     234|     120|     138|       3
---------------------------------------------------------------------------
  343-  367 (25.17/13.66)	TDGSYSGY..gegyadDFADSTGGEDN
  368-  394 (21.89/10.94)	AQGNFAKRrkmgleqrSRQVEVGGVRR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20795 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ALGGIGPGGLSHSEMIKHRQYIGTDDTAKPKPNLEPTPHRATPSASGTPNTHTPISRISRPERTGSKRQYTDGSYSGYGEGYADDFADSTGGEDNAQGNFAKRRKMGLEQRSRQVEVGGVRR
2) MSQSAKRQRTSYSPASPPYHIAAKPSETKTLIVQPNPPPSPPYPSMNSQSNGGFSSSAIGPPSVMTPPASVVMSQQYSPSGLTAGNPPTTFTPASTAGPSNSMHIDSDGDAMMLDTQDSDAAIRLGGRRRTDHNRQPRNIFAPDGG
273
1
394
146










Molecular Recognition Features






MoRF SequenceStartStop




1) NFAKRRKMGLEQR
2) SQSAKRQRTSYSPASPPYHIAAKPSETKTLIVQ
371
2
383
34