<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20794

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGILKMDPNGANGTASARDGDTKKRTYDGRFVNGDRNTPRPEASKPSTSMADQVAQLPPELAHVAASSYHPLSTLIERVNQECFNDLNDVLNAMAAIPTHHQTNGAMPNGLGSHNMGGSGRESAEANQQKKQLLIKFAQESRAKMIKLLVLTDWGKKSAAEISKLIDIFGWTRAQSADADAADVQLLEMKLLSNEARQRNPDIRTALEILATKKAEWLPDMGYIPPEPITSEKALHLLRYMNTSLYIRLTVHEKLPHHLRKWRVGSGRATFIVENEFEFDVMSFVEDTSDQWHFIDFRLLFSPAPVIDVDSRFLRELKLMMDGNLATEGKGLEECFNFLHNFTLTHKISVLRSQANELLRGAWAGSLRVESPHRQLVFYYWTDRPGKKSWIEIGISSNRPKDGKVSWRGPSIPSLTARWFRQGVEVKDVDLKIDWNNLSAERTLKHVVALHIGHLLHTARMGMFANASAKEILSTSEPADCRLVASLGASANKVTLSVQPATGRYILQPINMLSAQAEHAINRPYNPPSPSNAVTHLLAQALVGSVHKCAQQLGWHQVGQQSLRHDAVKTATKQEVIQFAIYQPRGWSVQAGSKWAIAMIVNAVGESWWLCKIGPANTTIEHAQQMNMERPKSEPDVTRATLSAIARVAVNAVAIHTNVQMLQQERMAFTLANDFAESRTSQKTQVIRGLVLHLKTSDLLASNSGEDAWLEPRIRLACHGLRVQSHKVWHIAAGTMIPAVAADMKKLMASSPQRNFNFSDDGHFQILIDTPFGEEVISKLKTRLRDIYRLRTFATILQKRKMLLVSSSLEHVKFQYGRDLTATVRFDKEDKVEVEFGKNAPHVRIQRLLNNVVNDTKRTSTPSRTFGLDAFCITLLITRPLLSAFDAIEASNTTTFGNPVIHTHSIGVYRLTYANPVCSFDVRLKQKGDRALWFIEDNEKKPTDLRPKNERTPNYKRPDALNKALRSLLDEKTERWYGVNTGIIAEIDGVPEALKRLHQVVMAHHDRNAAHPSPPANIKPVIKGSNGAPEKTNGVTAQNRPGGGGVGGGGGGNAAGGAAQLQRPPFNKANAFAGKAQVKREVIEIDD
Length1088
PositionTail
OrganismPericonia macrospinosa
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Massarineae> Periconiaceae> Periconia.
Aromaticity0.07
Grand average of hydropathy-0.381
Instability index41.37
Isoelectric point9.45
Molecular weight120867.55
Publications
PubMed=29679020

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP20794
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     271.09|      88|     105|     508|     611|       1
---------------------------------------------------------------------------
   73-  172 (134.42/79.64)	LSTLIERVNQECFN...DLNDV..LNAMAAIPTHHQTngamPNGLGSHNMGGSGRESAEANQQKKQLLIKFA.QESRAKMIKLlvltdwGKKSAaeISKLIDIFG..W
  514-  609 (136.67/109.56)	LSAQAEHAINRPYNppsPSNAVthLLAQALVGSVHKC....AQQLGWHQVGQQSLRHDAVKTATKQEVIQFAiYQPRGWSVQA......GSKWA..IAMIVNAVGesW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.29|      11|      16|    1054|    1064|       2
---------------------------------------------------------------------------
 1054- 1064 (19.63/12.32)	NAAGGAAQLQR
 1071- 1081 (19.66/12.36)	NAFAGKAQVKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.19|      12|      16|     387|     398|       3
---------------------------------------------------------------------------
  387-  398 (22.67/11.25)	GKKSWIEIGISS
  404-  415 (24.52/12.69)	GKVSWRGPSIPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     174.62|      56|     556|     417|     480|       6
---------------------------------------------------------------------------
  417-  480 (73.42/78.30)	TARWFrqGVEVkDVDLKIDwNNLSAERTLKHVVALHigHLLHTARMGMFANasAKEILSTSEPA
  974- 1029 (101.20/69.52)	TERWY..GVNT.GIIAEID.GVPEALKRLHQVVMAH..HDRNAAHPSPPAN..IKPVIKGSNGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.27|      17|      20|     209|     225|       9
---------------------------------------------------------------------------
  209-  225 (31.62/24.54)	EILATKKA.EWLPDMG...YI
  228-  248 (21.65/14.09)	EPITSEKAlHLLRYMNtslYI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.93|      22|     106|     751|     773|      10
---------------------------------------------------------------------------
  751-  773 (38.07/30.76)	SSPQRNFNFsDDGHFQILIDTPF
  861-  882 (39.86/27.08)	STPSRTFGL.DAFCITLLITRPL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20794 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KRLHQVVMAHHDRNAAHPSPPANIKPVIKGSNGAPEKTNGVTAQNRPGGGGVGGGGGGNAAGGAAQLQRPPFNKANAFAG
2) MAAIPTHHQTNGAMPNGLGSHNMGGSGRESAEANQQKKQL
3) MPGILKMDPNGANGTASARDGDTKKRTYDGRFVNGDRNTPRPEASKPSTSMADQVAQLPPELAH
996
95
1
1075
134
64










Molecular Recognition Features






MoRF SequenceStartStop




1) GAAQLQRPPF
2) MPGILKMDP
1058
1
1067
9