<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20793

Description Uncharacterized protein
SequenceMTSRPGPGIQESLQHRGGGSAYAPARRAANPQHGQQDSTADLDRAPLEDRVTKPRYKAKPIPLEAIQTSTSEFLRPSPRGKPQLFFTNPIAVGADFSSHGQAAPCLPVPPRPGFSTPGDGFQQPRIVPGGSGVKAEAATKLQGNDAPAPALMFPGGKTADLFPWAGNHPEDVMSEALVKGGISNKSQIMNETNTARPSLWSNLKNKSGINTLSTLFVAVLEKRQSCNRLTAPNTFKPPPRLTLRDSTRETWLHDLANPTIGLRRLSRTIPHGITGKVLLEQCLNKNIPIPRAIWLAKCVGINEMRTHKRKGQAGAISWIRGWTSSVEQFLESTIATIGQQDWKPRVTYALQLTTHLFKERLLENDHFLDWALKNLDSCSHERLFIWLLIICIPDFWNDIVSARRRGKRLAESLLDHTEKFYGAQENTESMPVLSFLENVLVRLVVTMPACLLLPITWAKHSSVLHLLAERRPQIDIVNAITSLDARNERLAQPSRTSASLSNDPVGRVYQLLDSVDYSSKICIDDLSYDCLQMIYDTTQLVFTVLSWACSLYRQGCCRIYLATRLLRKWNHLGTDIYDAILACLPRLALDQTKESCAIFRIIAELVRSKTFSPGRFLQWLIATGSLSQHQDIRSPSAWPLRLVTEIPLSGLSENVQNLRNTLLRGTSYSVEMEEQAIEAAETTICHQLPGLFNINHLNSVQPGSAFKEYSSTVRLEVGAWLRQEVAASMEFMENVPTKDASVEVAGAVCMISLSDFHVVRSYLEDFEDHSILADIVGIVATTLDSNVLSAAADTLSYNLEAFRAIGAFEPLFEKIAMRYAAIRTVRFPERDLLLSLTDLARTAHADPQLMQLLMYDLSRYDQRNSLAACSPASDSMVDGITNLDVEEEIERSLSSGTSMDQQMMSRVFEKIVANLEDQLCKHSNPVENFSTWLYRLRSFEENTFEEVLSSWIKTLLLGHQTQILSTALPLLIASGSLTFNSFLKTLQECINGRRATQPEESLRIAIKGLDTLLPARHMQGSCRQQDLYRYRLEQRRFCRQQNANIINLVKTIAEVVSASQIHIKDHALLEVCSSDRLLDLLRYFAIMDAHSLSTLASFRSQASGDPPCPNFGLLFRRLLDPLGRLQLSKMSLEQQVATVVPHADYLSLPFCQLALQQIFAASASSTEEVVESVSAVFLGTIKNAIEREHSCWSELVSGLEPGLVNKIREHAERTVIDTTAFLCGPLTARTSEEMKEKQTSIRRYLSVIEATTVGTLSDVQASFIASLTERFRGLLEIFTKNVDVVGPINQVILRSKSDLCYWLNVLLRLTVIHGSAMMTHASPQHQATFMWALWSLLSHPYIEDLPSIASSVFDVAVKLSDSISDDARKHLANMSAAKAGGDARCAFMFGTSVQSDGWLNLMKPVVSPANAQTASSSLQGQLPPSSTQASSSHSMQRSSSQQNIQQSHAQSQGRAYTQYPGNSPGYKMLPQQLQRVASNGQNGQASQLQQLQQMQAMAQQRGFQAVSGQQQRPVTAAPQQTAGAKGNAAKQEKVEMRAVPFSLNRWEILPESGGNLMGNETAISLGLFGARRA
Length1573
PositionKinase
OrganismPericonia macrospinosa
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Massarineae> Periconiaceae> Periconia.
Aromaticity0.07
Grand average of hydropathy-0.196
Instability index50.32
Isoelectric point7.88
Molecular weight174359.99
Publications
PubMed=29679020

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP20793
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.48|      14|      16|     267|     282|       1
---------------------------------------------------------------------------
  267-  282 (20.22/20.71)	RTIPhgITGKVLLEQC
  285-  298 (27.27/18.32)	KNIP..IPRAIWLAKC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.56|      12|      15|    1408|    1419|       2
---------------------------------------------------------------------------
 1408- 1419 (21.09/11.21)	PANAQTASS.SLQ
 1424- 1436 (17.47/ 7.97)	PSSTQASSShSMQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.18|      18|      20|    1471|    1490|       3
---------------------------------------------------------------------------
 1471- 1490 (27.13/18.90)	QQLQRVASngQNG.QASQLQQ
 1492- 1510 (29.05/13.88)	QQMQAMAQ..QRGfQAVSGQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.76|      17|      20|    1171|    1189|       5
---------------------------------------------------------------------------
 1171- 1189 (21.10/21.77)	ESVSAVFLGTIkNAIeREH
 1194- 1210 (30.66/19.63)	ELVSGLEPGLV.NKI.REH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.77|      13|      16|      89|     101|       7
---------------------------------------------------------------------------
   89-  101 (23.83/16.35)	PIAVGADFSSHGQ
  107-  119 (26.94/19.77)	PVPPRPGFSTPGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.35|      16|      16|     515|     530|       8
---------------------------------------------------------------------------
  515-  530 (28.88/18.99)	VDYSSKICIDDLSYDC
  534-  549 (28.47/18.61)	IYDTTQLVFTVLSWAC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      26.50|       9|      19|     358|     372|       9
---------------------------------------------------------------------------
  358-  372 ( 7.90/17.09)	KERLlendhFLdWAL
  380-  388 (18.60/ 8.11)	HERL.....FI.WLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.23|      13|      15|     829|     841|      10
---------------------------------------------------------------------------
  829-  841 (20.72/10.58)	ERDLL.LSLTDLAR
  846-  859 (19.51/ 9.56)	DPQLMqLLMYDLSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.77|      35|     176|      49|      84|      12
---------------------------------------------------------------------------
   49-   84 (58.19/33.41)	DRVTKPRyKAKPIPLEAIQTSTSE.FLR..PSPR.GKPQL
  227-  265 (51.58/25.00)	NRLTAPN.TFKPPPRLTLRDSTREtWLHdlANPTiGLRRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.48|      44|     298|     390|     484|      13
---------------------------------------------------------------------------
  433-  482 (70.75/110.47)	LSFLENVLVRLVVTMPACLLL...P.....ITWAKHSSVLHllaerrPQIDIVNAITS
 1299- 1350 (72.73/24.15)	LCYWLNVLLRLTVIHGSAMMThasPqhqatFMWALWSLLSH......PYIEDLPSIAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     214.58|      56|     294|     301|     356|      14
---------------------------------------------------------------------------
  301-  356 (97.12/63.05)	INEMRTHKRKGQAGAISWIRGWTSSV...EQFLESTIATIGQQDWKPRVTYALQLTTHL
  602-  646 (74.68/46.60)	IAELVRSKTFSPGRFLQWLIA.TGSL...SQ..........HQDIRSPSAWPLRLVTEI
  648-  687 (42.79/23.21)	LSGL...SENVQNLRNTLLRGTSYSVemeEQAIEAAETTICHQ................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.67|      13|      20|    1125|    1137|      16
---------------------------------------------------------------------------
 1125- 1137 (20.51/11.74)	LQLSKMSLEQQVA
 1148- 1160 (23.16/14.24)	LPFCQLALQQIFA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20793 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FSSHGQAAPCLPVPPRPGFSTPGDGFQQPRIVPGGSGVKAEAATKLQGNDAPAPALM
2) MTSRPGPGIQESLQHRGGGSAYAPARRAANPQHGQQDSTADLDRAPLEDRVTKPRYKAKPIPLEAIQTSTSEFLRPSPRGKPQLFFTNPIAVG
3) QTASSSLQGQLPPSSTQASSSHSMQRSSSQQNIQQSHAQSQGRAYTQYPGNSPGYKMLPQQLQRVASNGQNGQASQLQQLQQMQAMAQQRGFQAVSGQQQRPVTAAPQQTAGAKGNAAKQEKVEM
96
1
1412
152
93
1536










Molecular Recognition Features






MoRF SequenceStartStop




1) IQESLQHRGGGSAYAPARRAANPQH
9
33