<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20786

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEFLKSCSTNAQAIGEFDAVAYQAVSVTRNLTTAQTSFEWSPSDDIRAAEAELRQAQNLVVQDATRPWLWIFRSATVELPANTSPLRLPVVDGYQFHREQCGFMKASELARPPMRSASQNTPSTGSVSSPMTPGSTKPNPAGGGRLQQGNFPVGSTPDQQQQHDTFVVYELFTSAVVALIVYSLVKDHGAVALNYRTIISRATVQQDGGTVPHKLEHEYLSPNRLTNVDVFWASSGTLMVSTFTVPQTDMHCVFSVTGEEQKKILGKCIRLAPNGILAQIVSFEDPLETVVNDRNPKDRRKRPRTSPLEQGIERWKSTVKRWLAWKGYALKNLDHNSSWVRIRIAQPSPHASSSPALSHSSKEIMWPRALCFFYSTQTEDTYTPFAQGLASTRGDDGFKWFEALNSTGYTDPLDAAQRWFLGKPERDKIVEARRRAKKAEQDAVRSKDEVPNLLPSSPLNIRPGTYGDLQTASGVYPTPPDGILPGTVLSSADTPSVAGVGMNVILPPGGTNPAINLSAPQDIMQIDGQQQPPTSPDFTLSYDQYNTTGNHDDLFEDMEEDGFEANGVTDADFNFFDEPDDDVDMLDASNQEDTKQNAKKKAEQLKASTTSSDPTFESQSADPRSALESVLAAASKNNQVVQDTKPNAAIKTEESVDAKQITPPPRDSHTQITAAAPSVKENTPPLSPHFIEETLLPSVGTKPISKSHASTESHPRNSAFDPLDFNRKMSISDAKYQSGRFNFPLDKSQNRNKHEVEDASRKPKSLRDLPLVTKLRYAIGVAATKGLPDVPSPTDVDSDSSDDVSDDNSSVEDDVESSALFIPPFVPPGVAVPVKRKLPTEGNATPLSATSYADSFGGEYLEMLGLQTDDAALALLEPTLSDWSLVDVPAPVEIPSNQTRYSIPVFSPSNQSTPNTPVSPPDISMDMLDEKPLSGKDSIAVAQIVTAQVVSATLDILNEQQNRCLDDFTHHIPSESIWHEAIRAIFPAATNCNVTSFAAIQDVFPDLSQTKGQQRPPPRKPNEGPATLSHHMHHINPPHIRVRRSDVLWDLLPPALAFWEPLGLSPSSPPKNVVAFTVYPNSESLKLCVNNFMVNTQLAYDNCRLGSHTRVDTIPEYEGGLVPCKISNWTSTRAVFKALRDTCVQLGKQLSAKHAQMRGKEDTKIDAFVIYMIDPFENPSALWELCSAFWTLFQSYGQGPPGRHDQLPKPDLVLQVVPMKYVASFEAPVILDSSTYAGLAREVYDRCPPSAPCEDKTPLSIYTSPSFQLEEPIPRSVPFKLLAEPPHDLLHENSYIHLGYAISLDGMWVTAAWTDICGKFQSVVSYNLATRAFGDIAKEIWQTTIEILQARRVTWRVCIAKAGVMDREELEAWVFLVSCPTQINLFITLLTVDTEPHLKFTPTIPSSHPSATGGTNTPGSTPQGVVSPDHGLTPAATPSAENNTDPTTDPEARLVDATDETWGIILAHRLHNSNATNEFRPALISGLLVKRGLSPSYTITTTTSGPTNITSTSTSIPTAAPNSPDATVTPGPAIITVNILWMGAVNPTRAATSPFPPSTAAGTEGISPGGAGITNIVPPSPSPQERNYSSLTWTPTAQTRAAAENLLKEVLGQFRGLGLLARLKGIRGTRGGVVPWHVGVCLRGVGGLERVYPPGRA
Length1657
PositionKinase
OrganismPericonia macrospinosa
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Massarineae> Periconiaceae> Periconia.
Aromaticity0.07
Grand average of hydropathy-0.378
Instability index46.57
Isoelectric point5.38
Molecular weight180496.47
Publications
PubMed=29679020

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP20786
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.35|      20|      23|     722|     744|       1
---------------------------------------------------------------------------
  665-  684 (33.95/15.90)	PRDSHTQIT...AAAPSVKENTP
  722-  744 (30.40/20.28)	PLDFNRKMSisdAKYQSGRFNFP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      72.45|      19|      27|    1405|    1423|       2
---------------------------------------------------------------------------
  889-  904 (24.60/ 8.33)	PA..........PVEIPSNQTRYSIP...
 1405- 1421 (25.02/ 8.60)	............PSSHPSATGGTNTPGST
 1422- 1449 (22.83/ 7.14)	PQgvvspdhgltPAATPSAENNTD.PTTD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     437.88|     121|     128|    1048|    1174|       3
---------------------------------------------------------------------------
  992- 1123 (208.93/118.63)	CNVTSFAAIQDVFPDLSQTK...GQQ...RPPPRKPNEGPATLSHHMHHINpphirvrrsdvLWDLLPPALAFW...EPLGLSPSS.......P....P......KNVVAFTVYPNSESLKLCVNNFMVNTQLAYDNCRLGSHTR..VDTIPEYEGGLVP
 1124- 1252 (153.53/97.01)	CKISNWTSTRAVFKALRDTCvqlGKQlsaKHAQMRGKEDTKIDAFVIYMID....pfenpsaLWELCS...AFWtlfQSYGQGPPG.......RhdqlP......KPDLVLQVVP....MKY.VASF..EAPVILDSSTYAGLARevYDRCP...PS.AP
 1556- 1635 (75.43/35.85)	...................................................................PPSTAAG...TE.GISPGGagitnivP....PspspqeRNYSSLTWTPTAQT.RAAAENLLKEVLGQFRG..LGLLAR..LKGIRGTRGGVVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.33|      11|      16|     375|     385|       4
---------------------------------------------------------------------------
  375-  385 (20.84/12.57)	STQTEDTYTPF
  391-  401 (22.50/14.25)	STRGDDGFKWF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.67|      37|     160|     404|     441|       5
---------------------------------------------------------------------------
  405-  441 (68.17/45.09)	NSTGYTDPL..D............AAQRWFLGKPERD.KIVEA......RRRA.KKAEQ
  546-  604 (40.50/19.50)	NTTGNHDDLfeDmeedgfeangvtDADFNFFDEPDDDvDMLDAsnqedtKQNAkKKAEQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.00|      13|      15|     789|     801|       7
---------------------------------------------------------------------------
  789-  801 (23.25/15.47)	DVPSPTDVDSDSS
  806-  818 (21.75/13.85)	DDNSSVEDDVESS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.00|      15|     128|    1257|    1273|      10
---------------------------------------------------------------------------
 1257- 1271 (26.01/17.29)	TPLSIYTSPSFQ.LEE
 1277- 1292 (22.99/ 7.04)	VPFKLLAEPPHDlLHE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.99|      15|     137|     605|     625|      11
---------------------------------------------------------------------------
  607-  621 (26.50/ 9.99)	ASTTSSDPTFESQSA
 1510- 1524 (27.49/ 7.75)	TSTSTSIPTAAPNSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      88.61|      22|     137|     503|     526|      12
---------------------------------------------------------------------------
  479-  497 (29.07/13.24)	....PPDGILPGTVLSSA.DTPSV
  503-  526 (36.27/25.76)	NviLPPGGTNPAINLSAPQDIMQI
  530-  544 (23.27/ 9.32)	Q..QPP..TSPDFTLSYDQ.....
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20786 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AATSPFPPSTAAGTEGISPGGAGITNIVPPSPSPQERNYSSLTWTP
2) IPVFSPSNQSTPNTPVSPPDISMDMLDEKP
3) PDLSQTKGQQRPPPRKPNEGPATLSHHMHHI
4) PSYTITTTTSGPTNITSTSTSIPTAAPNSPDATVT
5) SELARPPMRSASQNTPSTGSVSSPMTPGSTKPNPAGGGRLQQGNFPVGSTP
6) SVAGVGMNVILPPGGTNPAINLSAPQDIMQIDGQQQPPTSPDFTLSYDQYNTTGNHDDLFEDMEEDGFEANGVTDADFNFFDEPDDDVDMLDASNQEDTKQNAKKKAEQLKASTTSSDPTFESQSADPRSALESVLAAASKNNQVVQDTKPNAAIKTEESVDAKQITPPPRDSHTQITAAAPSVKENTPPLSPHFIEETLLPSVGTKPISKSHASTESHPRNSAFDPLDFNRKM
7) TPTIPSSHPSATGGTNTPGSTPQGVVSPDHGLTPAATPSAENNTDPTTDPEARLVD
8) VEARRRAKKAEQDAVRSKDEVPNLLPSSPLNIRPGTYGDLQTASGVYPTPPDGILPGTVLSSA
9) YQSGRFNFPLDKSQNRNKHEVEDASRKPKS
1550
903
1005
1495
107
496
1401
430
736
1595
932
1035
1529
157
729
1456
492
765










Molecular Recognition Features






MoRF SequenceStartStop




1) MEEDGFEAN
2) VTDADFNFFDE
558
568
566
578