<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20786

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEFLKSCSTNAQAIGEFDAVAYQAVSVTRNLTTAQTSFEWSPSDDIRAAEAELRQAQNLVVQDATRPWLWIFRSATVELPANTSPLRLPVVDGYQFHREQCGFMKASELARPPMRSASQNTPSTGSVSSPMTPGSTKPNPAGGGRLQQGNFPVGSTPDQQQQHDTFVVYELFTSAVVALIVYSLVKDHGAVALNYRTIISRATVQQDGGTVPHKLEHEYLSPNRLTNVDVFWASSGTLMVSTFTVPQTDMHCVFSVTGEEQKKILGKCIRLAPNGILAQIVSFEDPLETVVNDRNPKDRRKRPRTSPLEQGIERWKSTVKRWLAWKGYALKNLDHNSSWVRIRIAQPSPHASSSPALSHSSKEIMWPRALCFFYSTQTEDTYTPFAQGLASTRGDDGFKWFEALNSTGYTDPLDAAQRWFLGKPERDKIVEARRRAKKAEQDAVRSKDEVPNLLPSSPLNIRPGTYGDLQTASGVYPTPPDGILPGTVLSSADTPSVAGVGMNVILPPGGTNPAINLSAPQDIMQIDGQQQPPTSPDFTLSYDQYNTTGNHDDLFEDMEEDGFEANGVTDADFNFFDEPDDDVDMLDASNQEDTKQNAKKKAEQLKASTTSSDPTFESQSADPRSALESVLAAASKNNQVVQDTKPNAAIKTEESVDAKQITPPPRDSHTQITAAAPSVKENTPPLSPHFIEETLLPSVGTKPISKSHASTESHPRNSAFDPLDFNRKMSISDAKYQSGRFNFPLDKSQNRNKHEVEDASRKPKSLRDLPLVTKLRYAIGVAATKGLPDVPSPTDVDSDSSDDVSDDNSSVEDDVESSALFIPPFVPPGVAVPVKRKLPTEGNATPLSATSYADSFGGEYLEMLGLQTDDAALALLEPTLSDWSLVDVPAPVEIPSNQTRYSIPVFSPSNQSTPNTPVSPPDISMDMLDEKPLSGKDSIAVAQIVTAQVVSATLDILNEQQNRCLDDFTHHIPSESIWHEAIRAIFPAATNCNVTSFAAIQDVFPDLSQTKGQQRPPPRKPNEGPATLSHHMHHINPPHIRVRRSDVLWDLLPPALAFWEPLGLSPSSPPKNVVAFTVYPNSESLKLCVNNFMVNTQLAYDNCRLGSHTRVDTIPEYEGGLVPCKISNWTSTRAVFKALRDTCVQLGKQLSAKHAQMRGKEDTKIDAFVIYMIDPFENPSALWELCSAFWTLFQSYGQGPPGRHDQLPKPDLVLQVVPMKYVASFEAPVILDSSTYAGLAREVYDRCPPSAPCEDKTPLSIYTSPSFQLEEPIPRSVPFKLLAEPPHDLLHENSYIHLGYAISLDGMWVTAAWTDICGKFQSVVSYNLATRAFGDIAKEIWQTTIEILQARRVTWRVCIAKAGVMDREELEAWVFLVSCPTQINLFITLLTVDTEPHLKFTPTIPSSHPSATGGTNTPGSTPQGVVSPDHGLTPAATPSAENNTDPTTDPEARLVDATDETWGIILAHRLHNSNATNEFRPALISGLLVKRGLSPSYTITTTTSGPTNITSTSTSIPTAAPNSPDATVTPGPAIITVNILWMGAVNPTRAATSPFPPSTAAGTEGISPGGAGITNIVPPSPSPQERNYSSLTWTPTAQTRAAAENLLKEVLGQFRGLGLLARLKGIRGTRGGVVPWHVGVCLRGVGGLERVYPPGRA
Length1657
PositionKinase
OrganismPericonia macrospinosa
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Massarineae> Periconiaceae> Periconia.
Aromaticity0.07
Grand average of hydropathy-0.378
Instability index46.57
Isoelectric point5.38
Molecular weight180496.47
Publications
PubMed=29679020

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20786
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.35|      20|      23|     722|     744|       1
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  665-  684 (33.95/15.90)	PRDSHTQIT...AAAPSVKENTP
  722-  744 (30.40/20.28)	PLDFNRKMSisdAKYQSGRFNFP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      72.45|      19|      27|    1405|    1423|       2
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  889-  904 (24.60/ 8.33)	PA..........PVEIPSNQTRYSIP...
 1405- 1421 (25.02/ 8.60)	............PSSHPSATGGTNTPGST
 1422- 1449 (22.83/ 7.14)	PQgvvspdhgltPAATPSAENNTD.PTTD
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     437.88|     121|     128|    1048|    1174|       3
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  992- 1123 (208.93/118.63)	CNVTSFAAIQDVFPDLSQTK...GQQ...RPPPRKPNEGPATLSHHMHHINpphirvrrsdvLWDLLPPALAFW...EPLGLSPSS.......P....P......KNVVAFTVYPNSESLKLCVNNFMVNTQLAYDNCRLGSHTR..VDTIPEYEGGLVP
 1124- 1252 (153.53/97.01)	CKISNWTSTRAVFKALRDTCvqlGKQlsaKHAQMRGKEDTKIDAFVIYMID....pfenpsaLWELCS...AFWtlfQSYGQGPPG.......RhdqlP......KPDLVLQVVP....MKY.VASF..EAPVILDSSTYAGLARevYDRCP...PS.AP
 1556- 1635 (75.43/35.85)	...................................................................PPSTAAG...TE.GISPGGagitnivP....PspspqeRNYSSLTWTPTAQT.RAAAENLLKEVLGQFRG..LGLLAR..LKGIRGTRGGVVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.33|      11|      16|     375|     385|       4
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  375-  385 (20.84/12.57)	STQTEDTYTPF
  391-  401 (22.50/14.25)	STRGDDGFKWF
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.67|      37|     160|     404|     441|       5
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  405-  441 (68.17/45.09)	NSTGYTDPL..D............AAQRWFLGKPERD.KIVEA......RRRA.KKAEQ
  546-  604 (40.50/19.50)	NTTGNHDDLfeDmeedgfeangvtDADFNFFDEPDDDvDMLDAsnqedtKQNAkKKAEQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.00|      13|      15|     789|     801|       7
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  789-  801 (23.25/15.47)	DVPSPTDVDSDSS
  806-  818 (21.75/13.85)	DDNSSVEDDVESS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.00|      15|     128|    1257|    1273|      10
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 1257- 1271 (26.01/17.29)	TPLSIYTSPSFQ.LEE
 1277- 1292 (22.99/ 7.04)	VPFKLLAEPPHDlLHE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.99|      15|     137|     605|     625|      11
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  607-  621 (26.50/ 9.99)	ASTTSSDPTFESQSA
 1510- 1524 (27.49/ 7.75)	TSTSTSIPTAAPNSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      88.61|      22|     137|     503|     526|      12
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  479-  497 (29.07/13.24)	....PPDGILPGTVLSSA.DTPSV
  503-  526 (36.27/25.76)	NviLPPGGTNPAINLSAPQDIMQI
  530-  544 (23.27/ 9.32)	Q..QPP..TSPDFTLSYDQ.....
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20786 with Med13 domain of Kingdom Fungi
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