<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20782

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMEDQSYPSMDVDDLFGDAEQVALPSINVIATPPVKGLAKRLDELSTSGCSSKIAWSKNGCVAYITPDRYAVHIRVFSRDPSTGKWDLGKATPVDIPHGQDDFPFVHVSWSNLGNDLSIINAAGQVMIFSCAMALDRMGYMRSELTHPEADMDFVIGMHWLAIMPHEQQNQIAWSANKIGDTWSFHIEQHHFKHMHHPADQKAALVYLKSRGDLRLRFQQPDSSWQEVGSPLESTLSTREAFTHAAFASNGDNTLLLAAYAVSGRLHLYRVETSWNVPPLKPGQPHPKQYDKPQIVISLLNIEDNCYPTMMSSDMNGGGESRVRLPAQLTHLDFLPATPEKNDGSVPTIQMVFSTPPNVVPMDQTQQAQTPFSVVVRWEVHQLQRNMLHSSLDKVSSKKKSVNSVPARNIWTLKRQEDGMMHSVVLSFTPIWYSMVLGFVYSDGTIEFRKRGTMAIISPDYSTEAVTSMSQSGFSFPPHEASLYTALSPNQCVAACMQTDGKITLRSMDYTHGSLSAAEDPDHRISAALAALALQTSTAANQYITSDDIFSIIENLPASRKDEFTKLMFQSLSVSIDCGIDDQSSNHLILLGRSPFFVKTLSAIHVLGLHGKVSRSLSSLTAWVILNIKYVTQIITTIARMHGQIDKQPLRPEVVPQFVGLCQWSMHFMTYIIDDLLELSRGLTKPGAPPLTKDLLEATLHQSKRPALLFLLSGFPRTMLKLWTQPLAWVMRSAATYSNASAPPEMRKLYTPLHAVLHEAPADFRQFDYLIREVEHLVRGCYRRDPSASKEGKEGEAARNQAERELLAGRIPEVLWPAARKLVSESLWGPAQGRGEAAEAMYFADKVDVARITFFDTTWLGFTDSRRAQSYFDTHVVDVCQKMVIRGPSAQPHHGALSRSAKRNRSDSIQSAGGAGNVDDKRKERKLRQCVRCSACMEDVLMGLPGYAATHVSWLMGVAKHCICGNSWMLVNEKDLLK
Length977
PositionTail
OrganismPericonia macrospinosa
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Massarineae> Periconiaceae> Periconia.
Aromaticity0.08
Grand average of hydropathy-0.246
Instability index46.50
Isoelectric point6.95
Molecular weight108850.12
Publications
PubMed=29679020

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20782
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     194.65|      47|      47|     101|     147|       1
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   53-   98 (51.76/28.74)	.......IAWSKNGCVAYITPDryAVHIRV.FSRDPSTGKWDL.....GKAtpvDIPHG
  101-  147 (80.64/48.96)	DFPFV.HVSWSNLGNDLSIINA..AGQVMI.FSCAMALDRMGY.....MRS...ELTHP
  150-  197 (62.25/36.09)	DMDFViGMHW......LAIMPH..EQQNQIaWSANKIGDTWSFhieqhHFK...HMHHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.72|      17|      47|     214|     232|       2
---------------------------------------------------------------------------
  214-  230 (32.93/20.50)	RLRFQQPDSSWQ....EVGSP
  264-  284 (27.79/10.54)	RLHLYRVETSWNvpplKPGQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.96|      15|      16|     888|     902|       3
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  888-  902 (26.99/14.05)	SAQPHHGALSRSAKR
  907-  921 (25.97/13.28)	SIQSAGGAGNVDDKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     140.41|      46|     102|     670|     722|       4
---------------------------------------------------------------------------
  670-  722 (63.07/61.72)	YIIDDLLELSRGLTK..PGAPPLTKDlLEATLHQSKRPaLlflLSGfpRTMLKLW
  768-  815 (77.34/48.70)	YLIREVEHLVRGCYRrdPSASKEGKE.GEAARNQAERE.L...LAG..RIPEVLW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     135.35|      42|      47|     451|     497|       5
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  451-  497 (65.79/54.52)	GTMAIISPDYsTEAVTSMSQSgfsfPPHEASLYTALSPNQCVAACMQ
  500-  541 (69.56/42.66)	GKITLRSMDY.THGSLSAAED....PDHRISAALAALALQTSTAANQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20782 with Med16 domain of Kingdom Fungi
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