<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20779

Description Mediator of RNA polymerase II transcription subunit 7
SequenceMAQPPPEEEEQFLTSIFPAPPPFYKHFTPTNLSALKDAQEKLSPNTNDQNSNKNSKDASSSSFPTTTLTPTQLLDLPAPLREQLTYLIPPPPPDPSVEYRVFGKPTKLGGDDPFEYIMQYVRNRLWNPDTSQGLLPLWEYERLYPADPSSKSSLSREGAGDTQMTDENNNNNTQTTQQQGEGGGGGDWGTLDRQTYLFRFLRSIIIKHVELLGILATDPTAPAPPDADGNGPQVILPENPFNPGTPLYDKAKDKVLREILNLVMNMHALINEYRPHQARETLIRVLEGQVERKKKEIEGVRRMAGRVGEALEGLRGAAAAAGGGEEGGGVDGNEGEGSSSGGGGGVEKDEEKIAMREMWRALEGV
Length365
PositionMiddle
OrganismPericonia macrospinosa
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Massarineae> Periconiaceae> Periconia.
Aromaticity0.07
Grand average of hydropathy-0.732
Instability index46.60
Isoelectric point4.85
Molecular weight39949.04
Publications
PubMed=29679020

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364060
ECO:0000256	ARBA:ARBA00003669
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP20779
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      69.02|      16|      16|     316|     331|       2
---------------------------------------------------------------------------
  299-  315 (21.53/ 8.51)	GV...RRMAGrVGEALEGLR
  316-  331 (28.88/13.55)	GA...AAAAG.GGEEGGGVD
  332-  347 (18.61/ 6.51)	GNegeGSSSG.G...GGGVE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.66|      17|      70|       4|      22|       3
---------------------------------------------------------------------------
    4-   22 (30.80/17.99)	PPPEEEEqfLTSIFPAPPP
   77-   93 (35.86/15.66)	PAPLREQ..LTYLIPPPPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.84|      13|      16|     123|     135|       4
---------------------------------------------------------------------------
  123-  135 (24.94/14.30)	NRLWNPD.TSQGLL
  141-  154 (17.90/ 8.48)	ERLYPADpSSKSSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.27|      15|      19|     214|     228|       5
---------------------------------------------------------------------------
  214-  228 (28.02/13.46)	ILATDPTAPAPPDAD
  235-  249 (30.26/15.11)	ILPENPFNPGTPLYD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20779 with Med7 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ADPSSKSSLSREGAGDTQMTDENNNNNTQTTQQQGEGGGGGDW
2) ALKDAQEKLSPNTNDQNSNKNSKDASSSSFPTTTLTPTQLLDLPAPLREQLTYLIPPPPPDPSVEYRVFGKP
3) ATDPTAPAPPDADGNGPQVILPENPFNPGTPLYDK
4) GLRGAAAAAGGGEEGGGVDGNEGEGSSSGGGGGVEKDE
146
34
216
313
188
105
250
350










Molecular Recognition Features






MoRF SequenceStartStop




1) EQFLTSIF
2) PFYKHFT
3) PLWEYERLY
10
22
136
17
28
144