<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20777

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGIIMGHGSRNGSHTNHDRDQRPNGINGASHNTDKIQDKGKVRESQQNSAPVSSAMSNGLNGKLPEGLRHGAGENGDSRAMQARVDRLPEEIAHIAENYFPLSTLLARLAQKTHADLLGTLQELGQMPAPASAVNGNSSHHSATDDSSPENVNKKLRLINFATSSHEAWTKALVITGWSRKAEDVSHLIDVRIHLEAQKKLYTDAIDLMAENKRALHNFRLPNPDFKTALEVLTTGKASWMPDLNYIQPPPLTAKEVLRSLEKLNTLLSIRLNLNDYESIPFQFKHFTIKSGRATFSVPGEFEIDLTIADEEPASQYWFIDFRFLFQPSSGNMSPGIRWHLENKVNEVLLKDGLSGCYKYLHELILTYKINEFRRQAVTLARSTWIDTLRVEILNRPISIQYWLNRYTDFRNPKGVLIKGTKSWIILGVHSGGRKDDRPDPKATSRLFIRWFRESKEVKDIDIPFDATNISAESLLKSVISKHVEYILTAIYQTLVIKPLFANGDLELSLNISQDNPAESELKIQLTSEHRVSIKIDPISGRFVFGPMCRAYANFEAGLNDRVQDPASEGHVWIERLRLFLVTEDLSTRALSVGWNKVTNPELRLDKVQQFAGKDHLAVVWFRRYGWAKDWYLAVSQSMSGEKWYLVKTALVPTPLQSTNREIDCAIKLPIKTSSPKTTYSFLCTLNIFAAGVISHYTNMKILHAKHVHHMLGKGRLSKALTLPSVYARFSDLVPSKNRLPRTGKPWAKDIIRITFQGVEMFSSDFNDAGDLDSPVQSQMMQTPMTGSQPPSIVPKRPYSAGERSVLITEAQMLVPLPQALLNINEQVDKDIVFNAQTGSFAIRLHSRVGESVVPVLIERMVRVERLVEFVQVLHKHEKTLVCEMVSLGKIVFTYRHNSSATGADAMDVDLASNMYRATVDFSSTDNVMALVLERGNPHLRIADTLAKILNGPEGLDGIATFLPLTLPVLRALDIIETAWCSDELSAKGEAFVNVRAADSYLISAVLMPRKVAFEVRLRQRKGVPWWYVQRTDNASRGKGEDSLDEALKPLWNASGLRWQGMRVSAVAQGSGTETLLVKVDEVVRNFAMSGKGLDVIAPAQVSVPGPQKQAPPRQQQQQQRQQQPTPNQSQNQSQGRNNAPKREVVEID
Length1150
PositionTail
OrganismCadophora sp. DSE1049
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Helotiales incertae sedis> Cadophora> unclassified Cadophora.
Aromaticity0.07
Grand average of hydropathy-0.341
Instability index39.98
Isoelectric point9.09
Molecular weight128833.58
Publications
PubMed=29679020

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP20777
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.65|      26|      31|    1019|    1045|       1
---------------------------------------------------------------------------
 1019- 1045 (43.55/32.27)	LRQRKGVPWWYVqRTDNASRGKGEDSL
 1052- 1077 (46.10/29.32)	LWNASGLRWQGM.RVSAVAQGSGTETL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.69|      42|     117|      91|     134|       2
---------------------------------------------------------------------------
   91-  134 (67.80/52.07)	EEIAHIAENYFPLSTLlaRLAQ...KTHADLLGT.....LQELGQM.PAPASA
  205-  255 (58.89/38.81)	DAIDLMAENKRALHNF..RLPNpdfKTALEVLTTgkaswMPDLNYIqPPPLTA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     383.83|      99|     124|     263|     362|       3
---------------------------------------------------------------------------
  263-  362 (170.40/144.75)	EKLNTLLSIRLNLNDYESIPFQFKHFTIKSGRATFSvP.....GEFEIDLT..I.....ADEEP...ASQ..YWFIDFR.FLFQPSSGNMSPGIRWHLENKV.NEVLLKDGLSGCYKYL
  393-  488 (133.40/107.15)	EILNRPISIQYWLNRYTD..FRNPKGVLIKGTKSW............IILG..VhsggrKDDRPdpkATS..RLFI..R.W.FRESKEVKDIDIPFDATNIS.AESLLKSVISKHVEYI
  523-  607 (80.04/60.41)	........LKIQLTSEHRVSIKIDPI...SGRFVFG.PmcrayANFEAGLNdrV.....QD..P...ASEghVWIERLRlFLVTEDLSTRALSVGW...NKVtNPELRLD.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.28|      11|      15|      12|      22|       4
---------------------------------------------------------------------------
   12-   22 (21.94/13.55)	NGSHTNHDRDQ
   28-   38 (20.33/12.05)	NGASHNTDKIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.82|      18|      31|     927|     945|       5
---------------------------------------------------------------------------
  927-  945 (26.92/21.77)	DNVmALVLERGNPHLRIAD
  958-  975 (30.90/19.43)	DGI.ATFLPLTLPVLRALD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20777 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) APAQVSVPGPQKQAPPRQQQQQQRQQQPTPNQSQNQSQGRNNAPKREVVEID
2) LLGTLQELGQMPAPASAVNGNSSHHSATDDSSPEN
3) MPGIIMGHGSRNGSHTNHDRDQRPNGINGASHNTDKIQDKGKVRESQQNSAPVSSAMSNGLNGKLPEGLRHGAGENGDSRAMQARVDRL
1099
118
1
1150
152
89










Molecular Recognition Features






MoRF SequenceStartStop




NANANA