<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20774

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDPSEYPTNVISFNNFSSINYEYFESHSTSSGAARKHLQRVEAGWRQDGRLVHHDPYREGVWLFYNGIASTGSPTKDSDTSSSSVDIQGLGLLQRERGIYEPASLARSKQILGSSMTAGSASSSPSSSLENALRNAQALNVKAIQANTSLSVMQEPPTPSPGAKAEFTASAKDIHEYFISAVLSSIVYFLSHDHNFIPLNSRTLIPASSRLIGSTSKPGNEIELATLEISLTSLGVLVLKAHSDMAPGLQTLRDVFSPSSTTCGLSPGAPLWLAPSGSAAKFYCVPDDNKLPGTLSIAQLQGSSFDSRPNGGINPLTIRSWQSRCLAWLSAKGLNSAALESGGWLYVQILGGHLPYSNSDSHGIPLLEELAIVPWPALLCFQTSNSSGARDSQTTDLVTPCRDPLSFAEDWFTSRDERAAIVSKRSKEKQAADALSKEQADVEARALQSHTFSPAALRRGSNAGAMYPTPPDAPQHPVGATPSFDGNVSTPGNPNHLIAHEAGGALPPNPTVVDADTDMWGTSAKKDRTNSTVHYNENDNDNDNDNDNDHDHDNDNDNLFGDLGGDMFGTHITDDDFNFFDEPDVDEFDVKQPSPAPIPTTKEPDAIAQVPESTMSITGADETNGTRVVVVEDSLDHKEISGLVTVDVAAVAPDALAAGSGQTKAEATQHSQPIVNLPFNKEIIFQKLVQESTMSKARKQPRRASLFKQIEFEDSLRSVNEKYSSHGQFDFFHQRRKQNPGEISGLPQTQYLTSRRKAHEGTLEMENIARMLGEKALDSQPKLVEDPMDYLMTSVGGSPVSEQDDSSHTTDEALVGSKFGIKRKWEGDDEDDIASTFDTLAMEFEQSVGTPQSMSGSQLPLLDADPADWALTTYFTSPEPDVEPNTLSDLERIATAQILADQAVSGTLHLPGLNGSDTSPSWDRCSATKLLLNKLSKAANSCLKDGTICSMRAFLDIQGIPILSQALRLPPRPTPNPRGPNGLDTRPNNPFMIIPPQIEVRRSESKLSILPSSVPFWENLGLGPSKDTKDIDAVCVYPNLEGVAAYANTFLDQMRSVYESSRFGSHDRVESKDIGSGLLPFAVDTTSQNKMHHLTTLKETAARLNRTLSSLPVGERNFVVYFVYPVDNSVLLVHICSAFQHLFNLYRKALSERRANTANELVLQLIPLDFIASPTSLAIPTPSKYFQLSMEVYDRCIDFTSSSSSPAIMLEQPLPRTIDFKLNANPSASLLQENTCLHIAYAQSIDDRWITAAWTDNRGTRQMTASYCLGRKNEPISTSFTEVANEIWETTLQVVGSKKIHWRIIIARVGVMDSSEFEFWTGLASKESNAQISLTLVTVQTDPSLKLLPAFITLTPNGYGAQSVITPVSTPQALQASILSPENAPTPVRENSTAAPAEAPAEPDQDVRLIDYTDQSWGAVLSHRLNNSNSLMETNPALISGYLIKRGGTNAVDPPIVMEVNIVHSEVVGNPRTFHESLLREMLGYYRGLGTLARARGVVDAVLDIRPWHIAAAEKAVKTLYMLM
Length1524
PositionKinase
OrganismCadophora sp. DSE1049
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Helotiales incertae sedis> Cadophora> unclassified Cadophora.
Aromaticity0.07
Grand average of hydropathy-0.351
Instability index45.71
Isoelectric point5.08
Molecular weight165969.62
Publications
PubMed=29679020

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20774
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     334.75|      94|     300|      44|     148|       1
---------------------------------------------------------------------------
   44-  138 (153.98/91.63)	GWRQDGRLVHHDPY....REGVWLFyNGIASTGSPTK...DSDTSSSSVDIQGLGLLQRERGIYEPASLARSKQILGSSMTAGSASSSPSSSLENALRNAQA
  299-  341 (41.11/15.51)	.................................................QLQGSSFDSRPNGGINPLTI.RSWQ..SRCLAWLSAKGLNSAALES.......
  343-  440 (139.66/77.68)	GWLYVQILGGHLPYsnsdSHGIPLL.EELAIVPWPALlcfQTSNSSGARDSQTTDLVTPCR...DPLSFAEDWFTSRDERAAIVSKRSKEKQAADALSKEQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     157.28|      48|     300|     746|     793|       2
---------------------------------------------------------------------------
  746-  793 (85.97/60.37)	LPQTQYLTSRRKAHEGTLEMENIARMLGEKALDSQPKLVEDPMDYLMT
  854-  872 (21.60/ 8.79)	.........................MSGSQ....LPLLDADPADWALT
 1079- 1112 (49.70/31.31)	LPFAVDTTSQNKMHHLTTLKETAARL..NRTLSSLP............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.37|      43|      78|     592|     635|       4
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  592-  635 (69.79/49.73)	QPsPAPIPTTKEPDAIAQVPESTMSITGADETNGT..RVVVVEDSL
  672-  716 (68.57/44.21)	QP.IVNLPFNKEIIFQKLVQESTMSKARKQPRRASlfKQIEFEDSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     131.73|      37|      39|     454|     490|       5
---------------------------------------------------------------------------
  454-  490 (68.92/35.58)	PAALRRGSNAGAMYPTPP..DAPQHPVGATPSFDGNVST
  494-  532 (62.81/31.72)	PNHLIAHEAGGALPPNPTvvDADTDMWGTSAKKDRTNST
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20774 with Med13 domain of Kingdom Fungi
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