<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20769

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMDTIPNEFPISLRSWPSSNSTDALPSIIQRINLERGGFQNITEESLREEIAREELNNGDNGESSSEDEEEPDRAKELNAAREEFIREIEQAHQASMLALDFISLLLSKDAPVQASLSLSPDLQQLVGVKTLGADKLAGPRTTEAQKQDNRNIAKGWKAQHLNKTVDSILASATRLEKEIEHETNYWEQVLAVSEKGWAICRLPNQKHILGVRFGFSESSPAFKSRSLAALNRKPDGTISLDQGLADAEPKSLRVRIEVDGVYTGSSTLPKAAPQDSPVEALILQARNTIFSEELWQELNRESRILEPVKLKDGTLIYQLSASRTMVLDLVPLEEEPVHSAGRDDAIAEGIFLALNILLSAAHRQAHRRRTQPPPPITLEKRTTPPLNILRPFITRVKHQEMTSSLRDILRPFHRVLSSIKLDSPPTYTQIPTIWPPLTHLSIAERTVLALTERLEATATLTITPTTTITIKAQTHSHPTIYPQFFLSISPPSSPLHITCPPPPRMESLAAVQQYIYYATSCTLASLFVPNPLFPLPTPHLEPPASSPYTKRTPIQEWVQSTTPSVLTKPLATSAKTKQLAFTIRCTPASLSRGGARTILRVQWEWARGELSGIEQAPFQIDGFRSDLWGDAERAGRLFFSEEENIYGVQPVKDGNENENGDGEGGDRGKGKRKRGLQAEGYYEWIAWVGEDDDDKGFFEVVRSLGSVVESAGTLKEGNK
Length719
PositionHead
OrganismCadophora sp. DSE1049
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Helotiales incertae sedis> Cadophora> unclassified Cadophora.
Aromaticity0.06
Grand average of hydropathy-0.450
Instability index57.55
Isoelectric point5.65
Molecular weight79871.21
Publications
PubMed=29679020

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20769
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     142.18|      35|      37|     480|     514|       1
---------------------------------------------------------------------------
  409-  479 (30.81/10.70)	LR.......PfhRVLSSIkldSPPTYTQIPTIWPPlthlsiaertvlaltERLEATATLtitptttitikaqthsHPT
  480-  514 (68.02/32.04)	IY.......P..QFFLSI...SPPSSPLHITCPPP...............PRMESLAAV................QQY
  515-  548 (43.35/17.89)	IYyatsctlA..SLF..V...PNPLFPL.....PT...............PHLEP.PAS................SPY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.94|      22|      45|      17|      38|       2
---------------------------------------------------------------------------
   17-   38 (35.63/17.28)	SSNSTDALPSIIQRINLERGGF
   63-   84 (32.31/15.11)	SSSEDEEEPDRAKELNAAREEF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.73|      33|      45|     194|     234|       3
---------------------------------------------------------------------------
  194-  234 (46.34/48.33)	EKGWAICRlPNQkhiLGVRFG....FSESSPAFKsrslAALNRKP
  241-  277 (52.40/31.36)	DQGLADAE.PKS...LRVRIEvdgvYTGSSTLPK....AAPQDSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.52|      17|      31|     354|     370|       4
---------------------------------------------------------------------------
  354-  370 (29.08/19.66)	LNILLSAAHRQAHRRRT
  386-  402 (30.44/20.91)	LNILRPFITRVKHQEMT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.02|      15|      17|     602|     616|       7
---------------------------------------------------------------------------
  602-  616 (29.19/18.79)	QWEWARGELSG.IEQA
  619-  634 (23.83/13.97)	QIDGFRSDLWGdAERA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20769 with Med17 domain of Kingdom Fungi
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