<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20764

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLMMDDEMNMDDLFGDGGGLSLPSRPPTRELHQRVDELRASGCCQSIAWSKWGSIASIASNGTTLELRNLRCHPDDGTWALSEPTTTPNFSASLDGCPLKHLAWSPTGSDLAVIDAVGRVTILSIYSSINKPALSRPCHLDPADDLHAVVGSFWLNQAPYPPGRPTILHGPGVKEGAVYRYEASQAPILGPCHPVQAKSALVCVTTNGLLKVLWQQNNNKWCESHTELESIVSSDDLITHAAICPDKSGTLLIAFATTSMQLRTVRALVDWGQLKVEKAPPQALPLNPTVRSKHLAGTSWVPDGPTDPMNVSHSDSSMVQLSHLELLPPTADNNGSPVPATIVAIRSSLPSLTSHYNQDVHSTIDRWEIQEPNPRAHPAFEQLSSRRNSTGITPPPVAYMKKLESITVNKIVVAMETMNTGRVIVIAYSDSSVEYRDRRNMLETFNDNNLDRVWHLSQIGLSYTEDEPCLQVALSPSYCSVVQIRNDGKIKWKQLDYHLGDIGKSMDEPIYSAVITALSLSCATAVMRNVNYDDILAAASKHVNPQFSYDWLTEISRILKVNLDYSEETHHDVLVRNTSIQLCLSIQQSLGFKGQFNPRTFSSKFAWVVLQLRNIVVLVSMAANLHISSGPNATEKSSPLEDPEVIRSLAGSVNWVLNLMAWIIDTLTNLPASLPPNIDLSSTTNLSLPDLLAHLHSTNTIALHLILSSASRGFLTAILRRLAHLDYIARKAISHTSTPNPQNTPSALSPALKAAYVEIASLTASPILDIKTIETLLSSLSSSIKNAYASHTPPLSGSPQAERARNALEIKMHFGSSFPDAFKSVIVELFREDGGLLSAVKADIKPADLFFADFEILEVDEEGVMLEKRRGRGMTMDCFRKAWLLNPVKGQVENGTGAGGTGTGTEGNANAMVGRQGARWRRCARCAAVMEDVLTQRQALQWLVMQQRRCFCSGFWDTLLPGGLVA
Length967
PositionTail
OrganismCadophora sp. DSE1049
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Helotiales incertae sedis> Cadophora> unclassified Cadophora.
Aromaticity0.06
Grand average of hydropathy-0.137
Instability index43.51
Isoelectric point6.17
Molecular weight105747.32
Publications
PubMed=29679020

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20764
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.46|      42|      53|      43|      93|       1
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   17-   68 (69.58/49.70)	DGG.GLSLPSRPPtrELHQrvdelrasGCC.QSIAWSKWGS.IASIASNG..TTLEL
   77-  126 (54.88/29.18)	DGTwALSEPTTTP..NFSA.....sldGCPlKHLAWSPTGSdLAVIDAVGrvTILSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     395.40|     105|     112|     229|     339|       2
---------------------------------------------------------------------------
  148-  222 (77.88/36.84)	.......................................HAVV..GSFWLNQAPyPPGRPTilhGPGVKEGAVyrYEASQAPiL..GPCHPVQ.........AKSALVCVTTNGLLKVLWQQNNNKW
  229-  339 (166.49/102.81)	LESIVSS.DDLITHAAicPDKSGTLliafATTSMQLRTVRALVDWGQLKVEKAP.PQALPL...NPTVRSKHL..AGTSWVP.D..GPTDPMN......VSHSDSSMVQLSHLELLPPTADNNGSPV
  343-  454 (151.03/80.85)	IVAIRSSlPSLTSHYN..QDVHSTI....DRWEIQEPNPRAHPAFEQLSSRRNS.TGITP....PPVAYMKKL..ESIT.VN.KivVAMETMNtgrvivIAYSDSSVEYRDRRNMLETFNDNNLDRV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.27|      28|      30|     740|     767|       3
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  740-  767 (47.95/25.67)	PNPQNTP...SALSPALKAAYV.EIASLTASP
  769-  800 (38.32/19.20)	LDIKTIEtllSSLSSSIKNAYAsHTPPLSGSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.62|      26|      30|     679|     707|       4
---------------------------------------------------------------------------
  682-  707 (42.75/29.43)	SSTTNLSLPDLLAHLHSTNTIALHLI
  709-  734 (41.86/20.83)	SSASRGFLTAILRRLAHLDYIARKAI
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.07|      30|      42|     455|     487|       5
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  455-  487 (49.56/39.45)	WHLSQIGLSYteDEP...CLQVALSPSyCSVVQIRN
  498-  530 (50.51/29.31)	YHLGDIGKSM..DEPiysAVITALSLS.CATAVMRN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.44|      26|      30|     823|     851|       7
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  823-  851 (36.46/36.30)	FKSVIVElfrEDGGLLSAVKADIKPADLF
  855-  880 (45.99/34.97)	FEILEVD...EEGVMLEKRRGRGMTMDCF
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.00|      15|     112|     551|     565|       9
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  535-  549 (23.59/15.68)	DILAAASKHVNPQFS
  551-  565 (25.41/17.47)	DWLTEISRILKVNLD
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20764 with Med16 domain of Kingdom Fungi
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