<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20763

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMSTSLPAWQTFLTRCIESRLDPETFSTYLAVLDTQEPLPPPRIVDLFLAPREESDYALDPLVSQYIQVLLSSGQANVPTVLRGLWKVSSFGHQINGDIEGNESQNNELGKTKAGKRWKNSYTTEETLFYRITKYISSGTAPRDLQEAVELIAVCIQWMETVVSASRVGHEMLSLAPTHTAEMPAQHMALGTLVIAVVENARVVHALGTRAVPKPTRKHLGKALEGFVPLLLQCSPQGAARLEVFRTETLVNLEPVEIKEPMAGADKEIEDILEDGLQLGVDSMVVEEMPVMNTRAGLYVYFNSLLVARPLIDDSTIFAYLHNRYQGDIRSTMVDIILAAFDILANAQSRNERAQSTTILRSFLINKIPLLLSSLSSSLFPPLTAEYCITEALRQVDINVFPTLSNMFDESSGGNMFPDSVRTDFCFACCLHGLVEESNIIELLGDEPLQSLPAEGRYAKDDLVQQCLSDPERAERLIDDLQLMNGNAGAVSQAITEVIARLCVNKETMSLKGLCSKLVKIPSSLDVMLLFDKPTSFLQPICDLLDNWHYDEDQGEYQPVYEEFGSILLLVLSYANRYNLSTVDLGIRNSDSFVAKLLNQGHLSRKMEQLSEQEQTHLDGWIKGLFDNESGGLGDELMSSCPPQDFYLLVPTLFHEIVLGCSTRNLSEDALKGGLEYLVDTFLLPSLVPGITWLACHLWESRGDGNAVLQILSALITSPTSISNNTEASQMLNSILNIVAKNLEHSLRWLQRAEPSRQDIEPLLKALRGNLGWERRGATGHTELESWTGSPNGGLVVAVKSTITHLIQWGLNPTLNSNPANYTHRQILVAVKMLSAKRVLAAIIDELKAQTTAGSGSVALDVACAIICAPDAASWDAGIQTDIMGTATITPQQRRMNLREALKMEADNAPKLHKTDPFLAETIVRLYRKVEAQLNMPQQTMLQHDALGDLNSAIEAVGMDALAADAALHGDGLGDGTDLGLGDPHADLMQGLMGGGADDLLRFSSGGDLGDGIGF
Length1014
PositionTail
OrganismCadophora sp. DSE1049
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Helotiales incertae sedis> Cadophora> unclassified Cadophora.
Aromaticity0.06
Grand average of hydropathy-0.055
Instability index50.38
Isoelectric point4.79
Molecular weight111093.43
Publications
PubMed=29679020

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20763
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.50|      40|      71|     661|     702|       1
---------------------------------------------------------------------------
  661-  702 (67.79/41.24)	STRNLSEDALKGGLEYLVDTflLPS...LVPGITWLACHL.WESRG
  733-  776 (60.71/31.43)	SILNIVAKNLEHSLRWLQRA..EPSrqdIEPLLKALRGNLgWERRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.32|      30|      35|     944|     975|       3
---------------------------------------------------------------------------
  944-  975 (46.32/34.86)	DALGDLNSAIEAVGMDALAADAAlhGDGLGDG
  982- 1011 (56.00/35.55)	DPHADLMQGLMGGGADDLLRFSS..GGDLGDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.13|      14|      16|     449|     462|       5
---------------------------------------------------------------------------
  449-  462 (24.97/14.00)	QSLPAEGRYAK..DDL
  465-  480 (21.16/10.82)	QCLSDPERAERliDDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.17|      11|      16|     530|     540|       6
---------------------------------------------------------------------------
  530-  540 (20.27/12.32)	FDKPTSFLQPI
  549-  559 (20.90/12.93)	YDEDQGEYQPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.12|      12|      37|      20|      32|       7
---------------------------------------------------------------------------
   20-   32 (17.91/15.61)	LDPeTFSTYLAVL
   58-   69 (22.21/13.96)	LDP.LVSQYIQVL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20763 with Med5 domain of Kingdom Fungi
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