<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20761

Description Mediator of RNA polymerase II transcription subunit 4
SequenceMDKLLDNRFEKVEKALATLITSISTYNPTPVLANNLVAADAELSEGLEQLSIHQSNYAKLLTLRESSNALDNQIRETLTLLTTTRQDLLATPATSLPTTTGGNPISYSELLSYARRISKFTLPPTYREPPAGDAEPISQTQTNGTNTPIVTTNGEAHTSTATEVDGSATAPGGQAQTQTTQHPGVSTNLSLWEQYLNQSADIPFVPWPAEEAIRKGALASIQILLDQGVDPVTFDPEKSAELEAERKRVTEADDAIREQEREDTRRRDLERRMSGGPVPERREEPKVFQLETFDDDDSDG
Length300
PositionMiddle
OrganismCadophora sp. DSE1049
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Helotiales incertae sedis> Cadophora> unclassified Cadophora.
Aromaticity0.05
Grand average of hydropathy-0.650
Instability index42.87
Isoelectric point4.56
Molecular weight32934.88
Publications
PubMed=29679020

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364141
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP20761
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.17|      20|      29|     196|     215|       1
---------------------------------------------------------------------------
  196-  215 (39.20/25.55)	LNQSAD.IPFVP.WPAE.EAIRK
  225-  247 (21.97/11.49)	LDQGVDpVTFDPeKSAElEAERK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.14|      15|      29|      92|     106|       2
---------------------------------------------------------------------------
   92-  106 (28.03/13.81)	PAT.SLPTTTGGNPIS
  123-  138 (25.11/11.68)	PPTyREPPAGDAEPIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.16|      27|      29|      24|      50|       3
---------------------------------------------------------------------------
   24-   50 (43.81/25.91)	STYNPTPVLANNLVAADAELSEGLEQL
   55-   81 (42.35/24.85)	SNYAKLLTLRESSNALDNQIRETLTLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20761 with Med4 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LLDQGVDPVTFDPEKSAELEAERKRVTEADDAIREQEREDTRRRDLERRMSGGPVPERREEPKVFQLETFDDDDSDG
2) TLPPTYREPPAGDAEPISQTQTNGTNTPIVTTNGEAHTSTATEVDGSATAPGGQAQTQTTQHPGVSTNLSLW
224
121
300
192










Molecular Recognition Features






MoRF SequenceStartStop




1) RRDLERRMSGGPVPERREEPKVFQLETFDDDDSDG
266
300