<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20758

Description RNA polymeras-like protein II mediator complex component Srb8
SequenceMTTRPVGRQPPQRSLSSTGAIHQRPPPLRTHSQQFTSSSPTRRGNEGGFVDLTLDGEVARPRIGTSRLRVEISTESKQADVVESPRPSSAATPTWRPSLPPRGRPQLHFDVPSVINPRSAQEGGQYDTTIKPMPLPVRPGQYVPPLSGKQRPLPVNTNKKDARPKPYTLEVPAIAPHYSPNGHADFYPWTGNHPEDQFSEPVIRQGYFDKAQMTQNETGSARSAIFPALKHKSGLQTLSSLFTNVLAQRRAHGQINSASTFKPPPRVTVTDTKREMWLKDLANPTISLRRLSRSIPHGIRGKVLLDQSLSKNIPIERAVWLAKCVGANELRSFRRKGASGTFAMGGEAKWIRDFTVCVEQFLESIVGSCGEKDFKARITYAIRLATHFHAEYLLDREHYMDWLVSSLESSPQTKLPMWLLITQVYWRDLLKYRKYGRRLSTALINHLAEISKHTDHDILAPLSDRLKDLLKGLLSTSADNFVSPRVWAIHKETVRSSFGSGDPQFLPILATIERRNSRFNPTGALKEPTARQRLITALDKTLREPFSNDLSRICWDIDGDKTMLILAVLGWSTSSYRPGTTKIFVAARIIRYWAKLGADVTGVILGFLDSTSNSSEINKPAFFHLVSELARSDHFSTPRYFQWLIARGGIYDSADVAADGPLSTRLLAELPMSNTSDSISDLRAALMDRADLSTDDESDLIQDCLVSMNGNLPGMHTGVDLDLESRSCFETSNIAELPSDLSRTIKSELGLWLRQKVSLQMLQPTIPPLDDWDVSPMKGGSSAITEADFNTVRRYLEDLGDYSMLADVLKIVTSSNDTEVLASCTDTLDLHLETFSAIGALNGLFDILMSRLRALTEETDSVPRGFLVSLSDLASRLPRENIIAQQLAQQLARSDRKTAADACSPVSDHMAIVETAEVDFTDEIERVLASGNSMDQATLERLFHRIILRLEESWKKFPEQQRSCALLLTRLRTFDAKQFDVLMLAWVSRVLHKESRPGMMEVFGPLISFGCLALRDVVTSCGLNNDRHLGGVNVDRPFTSRIAQELIHLLVAHCDLPEVMTLEETYRLRIKQSHAQRDFPIDTLLVLRHAFEAAQAAVNGSSQSLAFQALFASQDMYDIYRYYILTDAVAFTQNLILPLLQSSNSDVVDAVNTTVDKLLLASGASEFITPELLLSIADDLSLPFCQVKLAAMLQAQDTEMDGDHAESGHLAAFDRAIESAVEAGRTTWASIIPLLDVSISQHLRERADTQFLGLFPNLKANSSDGPWVHSRITRAENLLHIIDATAHSISTSPSQDSTNTSLASDMVIALNGIWLLLANSQSQDIKDSIISKWLPLLLSFMTIHVGTFEASKQGHECRAKATLALSAVYLQLEALDTGTEAIRNLIEQTFDLALHLVDNLPEDMRHQCIHSLRDTASSPAISYLFSIAANPTEWLVLRQRDRLQSVTGPDGKPAEKEKLTPFPLKRWEMLGEPTPNVGENDTSLSLTLFGARRVG
Length1495
PositionKinase
OrganismCadophora sp. DSE1049
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Helotiales incertae sedis> Cadophora> unclassified Cadophora.
Aromaticity0.07
Grand average of hydropathy-0.237
Instability index47.59
Isoelectric point6.22
Molecular weight166142.01
Publications
PubMed=29679020

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20758
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      82.49|      18|      19|     614|     631|       1
---------------------------------------------------------------------------
  479-  495 (24.50/11.72)	.DNFVSPRVWAIHKETVR
  614-  631 (27.90/14.38)	SSEINKPAFFHLVSELAR
  632-  647 (30.09/16.08)	SDHFSTPRYFQWL..IAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     196.24|      52|     129|      83|     134|       2
---------------------------------------------------------------------------
   83-  134 (95.09/48.98)	ESPRPSSAATPTWRPSLPP..RGR....PQLHFDVPSVINPRSAQEGGQYDTTIKPMP
  217-  265 (78.75/39.34)	ETGSARSAIFPALKHK.....SGL....QTLSSLFTNVLAQRRAHGQINSASTFKPPP
  280-  314 (22.40/ 6.10)	DLANPTISLRRLSR.SIPHgiRGKvlldQSLSKNIP......................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.06|      46|     523|     851|     899|       3
---------------------------------------------------------------------------
  851-  899 (59.98/51.21)	RLRALTEETDSVpRGFLVSLSDLASRLpRENiIAQQLAQQLARSDRKTA
 1371- 1416 (79.08/50.47)	QLEALDTGTEAI.RNLIEQTFDLALHL.VDN.LPEDMRHQCIHSLRDTA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.99|      38|     523|     535|     613|       4
---------------------------------------------------------------------------
  571-  613 (60.27/121.23)	WSTSSYRPGTTKIFVA..ARIIRYWAKLG.....ADVtgviLGFLDStSN
  772-  816 (56.72/24.62)	WDVSPMKGGSSAITEAdfNTVRRYLEDLGdysmlADV....LKIVTS.SN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.72|      15|      22|     699|     713|       5
---------------------------------------------------------------------------
  699-  713 (28.21/19.91)	DL.IQDCLVSMN.GNLP
  722-  738 (18.51/10.32)	DLeSRSCFETSNiAELP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.27|      24|     133|       4|      27|       6
---------------------------------------------------------------------------
    4-   27 (47.66/29.27)	RPVGRQPP....QRSLS.STGAIHQRPPP
  138-  166 (38.61/22.16)	RPGQYVPPlsgkQRPLPvNTNKKDARPKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.15|      14|     133|     831|     849|       7
---------------------------------------------------------------------------
  831-  849 (20.66/23.53)	HLETFSAigalnGLFDILM
  970-  983 (26.49/15.69)	RLRTFDA.....KQFDVLM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.01|      16|      19|     525|     542|      10
---------------------------------------------------------------------------
  527-  542 (26.68/20.91)	EPTAR..QRLITAL..DKTL
  544-  563 (22.34/ 8.73)	EPFSNdlSRICWDIdgDKTM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20758 with Med12 domain of Kingdom Fungi
Unable to open file!