<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20756

Description DNA polymerase delta catalytic subunit
SequenceMVSDVKADKLVQTSLGKKTQPKAFVALLNQLDEKAPIPDNELASSLLTLSKHRLQWKLQHQYAFAFANESAEKLRRIMSGLHGLPTDAQREFVLYLKSRYKAFKEPVLQFFVNQSLPDYTVQLQRSFQSSLDENSKNLWFHLLFLWGNIIDNASSVVQKEPFRALALEVMGSLQSLGATSQLAYFSKKANSLLNAAELHKELQTSALGNVKREKVSATPVRKAFALNQHSKKVMKIAKLKKLLWLNERFRQWNIEKLMEQYIAFFRVDMSKYDDTVKELVEILFTGISTAIQQQESPYVLFNWKNFIVSRFPLFLKESRPKNNDGSSNLESVILKTVSGFTDAYLIEMVVGGRSSHPYDLRKMFLRSCMYQDLVTVSSYTKTFPEDSESVTWSHITHEKNVLNHTDHLKTEFNSKLLNINTEFTSLGESKFINFLEDLPSSDIQYSVSKQEQLRSLVSSSLEKLIEEKSNEKLVRLVLGLSICLPVTNYVYFVDPRGPWGIIDPLIAYIDNDSFGADADDNNFQETFSYFGILMTGSIAITNFFGIDFISVTLGRSYTIDFMNKFYYRSCTNFSNKVEPEKDSDSGVINTYNEHLSEWANALFDVNNDGLSDDLIKSVNVKQIYKLVFVIFQSAITANIAGSLASPNLSNGIDYLSQDFLAPSSAELIHWIVSNIGPLQRNSDIFLQILWKIVQSNLGENKEEGSEINYTFRLVLNLVGKELLESVYAFRNWETKEIMLKLVRVVKQNADEEYNRIDRPLLIQHQKHTEGDSLASTIRQAAQIFLNEDGEESGKSIWRAFRTMWKVTESEEILTLLLNEIRSCHGSKASHGASAEEGKIIIDFMAFLVVLTSQSSTEMSDAELKSRFNEVKPRGISPMSFGSQFKLSIENHYASIFSGAASSEGAEKIADPVDVKLAPKDDLMMDFEMDDLFNDKGEDLFGDSGDAAISRPSSPPVKVGSMYKDVVSGTSVLRRVLNQLSQATETDHHDAEILKIVLSQQLEQSYSNKHTYHIYISMSEDPNALKRAWYHSQEGAHALPVGSQNIDSKLELSESQQQLLKRVKRPNGNEEPSEFEKELVEMTESASAFHEESQSWKRPPLPKDYTTRDISFQQLDAEEATHGDESSARFFGITSEGHSVLCNVTGFLHYFYVPVPRGFFPDQHLTQFTAYLKANYFGVETVEIVKKESIWGFNNSTKSPFFKVIVNNARNITKIRGAFERGEIRFEQLFPPSCVSYDNINYLLRMMIDCGITGMSWITLPAGSYTVTDNDLKVSTCQIECSVDYRKLISHPSEGEWLKMAPLRIMSFDIECAGRKGVFPEANQDPVIQIANVISRYGESRPFVRNVFTVKSCLPIIGSEIFSNEKEEDMLMAWRDFVVKSDPDVIIGYNTANFDLPYLLDRAKALNIPKFPYFGRMVNIKQEAKDSVFSSRAYGTRENKVVNIDGRMQLDLLQFIQREYKLRSYTLNSVSAHFLGEQKEDVQHSIITDLQNGTAETRRRLAVYCLKDAYLPLRLLEKLMCLVNYTEMARVTGVPFSYLLARGQQIKVISQLFRKCLQEDIVVPNMKSEGSNEEYEGATVIEPIRGYYDVPIATLDFSSLYPSIMMAHNLCYTTLLNKQSIKAFNLSEDDYTHTPNGDYFVKETKRKGILPTILNELLTARKKAKADLKKESDPFKRDVLNGRQLALKISANSVYGFTGATIGKLPCLAISSSVTAFGREMIEKTKNVVQEKYNTGNGYTYDAQVIYGDTDSVMVKFGHQDLETCMKLGEEAAAYVSTKFINPIKLEFEKVYFPYLLINKKRYAGLYWTNPDKFDKMDTKGIETVRRDNCRLVQNVITRVLEYILEERNVPKAERYVKQTIADLLQNRVDLSQLVITKAFSKHEYDSKQAHVELAKRMRKRDAGSAPTLGDRVAYVIINSSSSKNYEKSEDPLYVLENSLSIDVKYYLENQLSNPLLRIFEPILGEKRAKELLAGAHTRTIKMSAPKGGGLMKFAKKAELCKNCKSPLKANNKGALCENCISKAPELYCDALAQMNYLENKFSRLWTECQRCQGSLHQEVLCSNKDCPIFYMRKKAQKDASQQVQELQKWDETIW
Length2094
PositionTail
Organism[Candida] haemulonis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Metschnikowiaceae> Clavispora> Clavispora/Candida clade.
Aromaticity0.10
Grand average of hydropathy-0.343
Instability index46.84
Isoelectric point6.47
Molecular weight238210.76
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
4 iron, 4 sulfur cluster binding	GO:0051539	IEA:UniProtKB-KW
DNA binding	GO:0003677	IEA:InterPro
DNA-directed DNA polymerase activity	GO:0003887	IEA:UniProtKB-KW
metal ion binding	GO:0046872	IEA:UniProtKB-KW
nucleotide binding	GO:0000166	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20756
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.16|      15|      15|    1992|    2006|       1
---------------------------------------------------------------------------
 1992- 2006 (29.30/19.38)	KFAKKAELCKNC..KSP
 2008- 2024 (24.86/15.29)	KANNKGALCENCisKAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.60|      28|     423|     930|     959|       2
---------------------------------------------------------------------------
  930-  959 (44.85/33.76)	DLF.NDKGEDLFGDSGDAAISrpSSPPVKVG
 1359- 1387 (46.75/28.08)	EIFsNEKEEDMLMAWRDFVVK..SDPDVIIG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     272.84|      85|    1146|     308|     400|      10
---------------------------------------------------------------------------
  308-  400 (128.89/110.66)	VSRFPLFlkeSRPKNNDGSSNlESVILKTVSGFTDAYLIEmvVGGRssHPYDLRKMFLRSCMYQDLVTVSSYTKTFPEDSESVTWSHITHEKN
 1407- 1491 (143.95/97.81)	IPKFPYF...GRMVNIKQEAK.DSVFSSRAYGTRENKVVN..IDGR..MQLDLLQFIQREYKLRSYTLNSVSAHFLGEQKEDVQHSIITDLQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.58|      25|    1145|     491|     519|      11
---------------------------------------------------------------------------
  491-  515 (49.77/42.97)	YFVDPRG..PWGIIDPLIAYIDNDSFG
 1151- 1177 (43.81/25.96)	YVPVPRGffPDQHLTQFTAYLKANYFG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.46|      12|      17|    1692|    1703|      12
---------------------------------------------------------------------------
 1692- 1703 (21.55/12.09)	SVYGFTGATIGK
 1712- 1723 (20.91/11.52)	SVTAFGREMIEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.36|      14|     868|     473|     486|      15
---------------------------------------------------------------------------
  473-  486 (24.29/18.89)	LVRLVLGLSICLPV
 1342- 1355 (26.07/20.94)	FVRNVFTVKSCLPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.55|      14|      21|     986|    1005|      19
---------------------------------------------------------------------------
  986- 1000 (19.54/24.44)	DHHDAEILkIVLSQQ
 1007- 1020 (24.00/ 9.55)	NKHTYHIY.ISMSED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.99|      21|      21|    2039|    2059|      20
---------------------------------------------------------------------------
 2039- 2059 (39.07/28.56)	NKFSRLWTECQRCQGSLHQEV
 2063- 2083 (36.93/26.53)	NKDCPIFYMRKKAQKDASQQV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20756 with Med5 domain of Kingdom Fungi
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