<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20749

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSDSIPLSRISTHYYKIAHLSSVNYAVYTAKETSSDQFLLELELQIRDRFPRILLTYYSKCLYHFEFGHISDGSPSSDSDTTSYSGKIRLDQHYPQLALKRESSTKAAFLSKPAKHHAAQALNKKDQSVTEEHLAFVSLTFFKAVKKMIVYNLCLKSDTRMFGNYVVTNNRKEDGQYSVIQLDPVVLENGDLIVSLFQTNRLVLWDSQLVRSNEAFVELANSFVIYVVPSGLRCHFYDPLDYSQTFTTAAPKSSHTLLRLLKLSTGIDLTNKQNILWTKLIPNLQHLNNLTSNISHFIHEVDNKKYIMWPWELCLLQFGSHDITSKPKDKTSWSIDPLGLINRILDSNIAAKDHSSHNKDGSASVDMNAASSGQNFNFNAPSSLSTGKSSGHGATMEDISIRLETPQLDDFNYAVSQPIEREVSNPKAEQEIITGEDDMCTSSLSPPRIARKVDYNDSDTNDAEYEGIDDDLFGDGSEPEVFENDPVTTSIRDNNKGGHSSTDFSGEGTHRDTNFTPDKMNNREIKDLEAVDQGTPTTFVNIPKDQMISDLEPIPSSYKDPGLLYQSFPHSTVAFSDSSISHKDKVASTVQNSTKNERLNDFSCHEQRQGYVFSPIKFNPVIRSSIDTKYGKGGKFYVSHEPMDEADTKGRRMRETSVSHGSPLHLSNDYNDNDNESGQDIKLSTKLRAPERTNGSTGESGGLDSDSQVEDHLSRQDRREIDFQGSTEISENLGENDNVFDDAVPNESDDVDDEGGEEDESDEDEEVENDELETSPLRLNTSNQDPALGGPVDTNRNPSSNAYVPMPRSNVLSPASGVINIKVESPSTLAVRNELHGQSLSPMSIHQLELKDDLVAAANDTKDIDMSVPATSAASPTSISSSGMGESSNCLPLILRSINVLTIPPAFVLREEIDNWDGVTMSTGFDMDVVEEVEDLSNSNAGPLNVRGTDLDEYLRWVTSNLVFDFGNFETNAKILMRLPGDRQDERPESMAETEPSESMRNSFEEVFPLSSRVNLNEFRFGFSKQTDENSGRAQSTHMDNQLAFLEPAEGLQSQTSDMNSLYWDSIYYDAPGNQRNATSYWNILKQTERKWALQKGNDEAFLEMYDVKAKVLKPSSEIINFDFVGLRFWRYLNLTPVNRDRKFQILLISEYSPETYDLNVFENGNLSLLNMLRNNYKDNHFGDIKKLSLQTAENRQDLEGVINGTVLAERPRGDHSYSKFYSRTDKRLRSLAELIKLDLINKNNRFDFDRPLLLLFVNFDQSVGSISQISKLCRNFKAALKAHQLSLVEVFSHIIPGDKIVKQSAHLMRLKYISNTELTNLSMMLYNKCPDSKPKHSARNAKGTTGLFTRLIKERPESLSFKATNRGLNNDTDATLSEDLFLHVAYERSVDRRWISAAWSDPHGIVTHTKSWHCTTKRGGSSSAHDTGEVITEIWEISNSLLKFLSADDSRRACGSGGKRFLVLTRVNSILPDDELVFWKRLTAKHKEVSLVVLTANRLPRLTFSLQERALSDSGISEHTPSHSVSTSANRNHSVSGLAGVDLIKAFNGGPFPYMSSPNTAEMNTLNSPMNPGGINVLSPHQFVNVPGNFLSPHDGNGASNLPESNATDEMNLHLRDACLDLIGFIPQTSLPSSNSPTRLGMKTGYLIRDVKSKGKSSKGLMVFELSLLSCSSQWNLNSIMKILLNQFKKLIYLNHIIGICGLASTSGKDDGQNHRNLLRSMVPWHINAIGKSLDYLVHIRVDEES
Length1747
PositionKinase
Organism[Candida] haemulonis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Metschnikowiaceae> Clavispora> Clavispora/Candida clade.
Aromaticity0.08
Grand average of hydropathy-0.541
Instability index44.84
Isoelectric point5.37
Molecular weight195370.47
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20749
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|    1047.07|     342|     972|      67|     441|       1
---------------------------------------------------------------------------
   67-  441 (520.32/426.02)	FGHISDGSPSSDSD.ttsYSGKIRLDQhyPqlALKRESSTKAAFLSKPAKHHAAQALNkkDQSVTEehLAFVSLTFFKAVKKMIVYNLCLKSDTRMFGNYVVTNNRKED....GQYSVIQLDPVVLENGDLivSLFQTNRLVLWDS..........QLVRSNEAFVELANSFVIYVVPSGlrCHFYDPLdYSQTfttaaPKSSHTLLRLLKLstgiDLTNKQNIL.WTK.LIPNLQHLNNLTSNISHFIHEVDNKKYIMWPWELCLLQFGSHDItskPKDKTSWSIDPLGLINRILDSNIAAKDHSSHNK..DGSASVDM.NAASSGQNFNF...NAPSSLSTgKSSGHGATmEDISIRLETpqlDDF.NYAVSQPIERE.VSNPKAEQE.IITGEDD.MCT
 1045- 1416 (526.74/343.46)	FLEPAEGLQSQTSDmnslYWDSIYYDA..P..GNQRNATSYWNILKQTERKWALQKGN..DEAFLE..MYDVKAKVLKPSSEIINFDFVGLRFWRYLNLTPVNRDRKFQilliSEYSPETYDLNVFENGNL..SLLNMLRNNYKDNhfgdikklslQTAENRQDLEGVINGTVLAERPRG..DHSYSKF.YSRT.....DKRLRSLAELIKL....DLINKNNRFdFDRpLLLLFVNFDQSVGSISQISKLCRNFKAALKAHQLSLVEVFSHII...PGDKIVKQSAHLMRLKYISNTELTNLSMMLYNKcpDSKPKHSArNAKGTTGLFTRlikERPESLSF.KATNRGLN.NDTDATLSE...DLFlHVAYERSVDRRwISAAWSDPHgIVTHTKSwHCT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     488.82|     156|     721|     772|     942|       2
---------------------------------------------------------------------------
  517-  603 (102.24/46.80)	....................................................................PDKMNNREIK.DLEA.......VDQGTPTTFVNIPKDqmISDLEPIPSSYKDPgLLYQSFPHSTV..AFS.DSSISHKDKVA.STVQNSTKNERLNDFS
  778-  937 (252.43/154.18)	RLNTSNQDPALGGPVDTNRNPSSNAYVPMPRSNVLSPASGVINIKVESPSTL...AVRNELHGQSL.SPMSIHQLELKDDLVAAANDTKDIDMSVPATSAASPTS..ISSSGMGESSNCLP.LILRSINVLTIppAFVlREEIDNWDGVTmSTGFDMDVVEEVEDLS
 1502- 1571 (60.24/23.70)	RLTFSLQERALSDSGISEHTPSHSVSTSANRNHSVSGLAGVDLIKAFNGGPFpymSSPNTAEMNTLnSPM.................................................................................................
 1577- 1643 (73.90/31.67)	................................NVLSPHQ.FVNV....PGNF...LSPHDGNGASN.LPESNATDEMNLHLRDACLDLIGF...IPQTSLPSSNS..PTRLGM......................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     133.47|      31|     256|     476|     507|       3
---------------------------------------------------------------------------
  476-  506 (53.34/21.30)	GS..EPEVFEND.PVTTSIRDN.NKGGHSSTDFSG
  695-  725 (35.93/11.36)	GStgESGGLDSD....SQVEDHlSRQDRREIDFQG
  734-  765 (44.20/17.03)	GE..NDNVFDDAvPNESDDVDD.EGGEEDESDEDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.05|      16|     214|     442|     459|       4
---------------------------------------------------------------------------
  442-  459 (25.87/21.48)	SSLSPPRIARkvDYNDSD
  659-  674 (32.18/20.08)	SHGSPLHLSN..DYNDND
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20749 with Med13 domain of Kingdom Fungi
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