<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20748

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMCLTYLENTNGKDWQLAKATGITLKPSDDGAAAEIDMLKWSNLSTDLGVWDVNGNFYILLAGVGLINDKKGENGQNGTANGAISAPSPTKRDSDGPSYELTSYNHTEMIYRDIVPPQAHTKCVSFEWLNIEKPQIVNKSATLAGEDGSGYANYSYGVTQHHPPGTSHPIPTKQACVAVRQNGLLNLYYQGEHKVEYHKLSYNLAPDGREGSCTFTKAAIGFNNDKKIVIVAYDARSDLILTYVVSIDWGFLVDSAQRQRADPHYHTPKDGQNQPSISCSLVHEMRPEPTASIDYGDEKAFGRPEVVQQTLKSIELFSPFFQQGSSLEILVTYECMNPVGSQPFTSAYRYNLENAMDSVGDLFDSMGDGASNSDSREGLLRLVLQGHISLSKQVQQIETAISESLLLFIYTDGSIDAVNRETWEIIPNPGLKIEGQDSSATFPPTISSLLDCGFSFPELGANPALLAVSPNMAAFVHHADGQLQFKSLERLNGKENISLCGIGFAYMHACACYSTTSSDDLLVMLRNELSKTELESPELASKLVDLVMTESHKAINFQLNSFGKESVDKLLSNPPLQRLLSLQLVLGELHSDNRAIKDMAWIVLNLRSTSFGIMFSLSSIYRQMSKKKPAEDLLQDSVSRAECIMSLVGNVRWLIDLIVYFNQELLQLAFSRNRPSQSKVTVDNSVVLPVILGKVPRLFLMYSLSSIGKTHEILKKLYKELTESNKLYTPMKEALNRFFTACNSSPLNLGLFENFLRECEVYVNKELNNVVSNDRAQSLRLEQQLFCRGHVPDEVKYMANVLIDRHAATISRDLKLSDLYFYENNWIDVGIARKEFTKPYIPTDDEYKPMVPRLRYSDNEVVDALRKIIINAGPTVVSGGASAMGVEQFR
Length889
PositionTail
Organism[Candida] haemulonis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Metschnikowiaceae> Clavispora> Clavispora/Candida clade.
Aromaticity0.09
Grand average of hydropathy-0.248
Instability index42.09
Isoelectric point5.47
Molecular weight98915.10
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20748
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     157.68|      31|      43|     144|     174|       1
---------------------------------------------------------------------------
   62-   91 (25.15/10.44)	...GVGLINDKKG..EN.....GQNGTangaiSAPSP.TKR.
   93-  121 (28.09/12.46)	.SDGPSYELTSYNHTEMiyrdiVPP.Q.....AH....TK..
  144-  174 (61.82/35.54)	GEDGSGYANYSYGVTQH.....HPPGT.....SHPIP.TKQA
  190-  218 (42.61/22.40)	GEHKVEYHKLSYNLA........PDGR.....EGSCTfTKAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.95|      38|      42|     400|     441|       2
---------------------------------------------------------------------------
  400-  441 (53.05/45.71)	ISeSLL..LFIYTDgsIDAvNRETWEIIPNPGLKIEGQDSSATF
  445-  484 (61.91/37.33)	IS.SLLdcGFSFPE..LGA.NPALLAVSPNMAAFVHHADGQLQF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     157.59|      46|      47|     560|     606|       4
---------------------------------------------------------------------------
  512-  557 (39.52/21.06)	.YSTTSSDDLlvmlrnelskteLESPELASKL.VDLVMTESH.....KA......I........NFQ
  560-  606 (73.97/49.87)	SFGKESVDKL............LSNPPLQRLLSLQLVLGELHSD..NRA......IKDMAWIVlNLR
  609-  654 (44.10/24.05)	SFG.....IM............FSLSSIYRQMSKKKPAEDLLQDsvSRAecimslVGNVRWLI....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.16|      13|      49|     785|     797|       6
---------------------------------------------------------------------------
  785-  797 (27.53/16.59)	FCRGHVP..DEVKYM
  835-  849 (22.63/12.42)	FTKPYIPtdDEYKPM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20748 with Med16 domain of Kingdom Fungi
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