<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20740
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MTEPENVTLRFDSNVYGTAEDPFMQDEEKIPIAELIPRILLERQSFLNITEEQLEEEIVNKNGTPETKEEVQEVVETEEDTETVSQLFQKQKYELLGHINFAMNETSLSLDFISLLMSAVKPNITKSTISPHLSKIAPLGSLNSDRLNQDADAQEQEKNEKQAKRSKAENIGLGWKYQSLNHIKTLFQSAGESLRQQVDIEKTYWNMINEVLSHDEVLFRVRDPLTGSRAIGVKYGYGDSGSSYFDQGLAVLRKDDQTGDLSFSPIMTGNHKLSIKSNKYTRVKILSKFDDDYMLTGQSVFEKSVLEDKSPFRVINDIEKARYFLFEDDLLYHLIREAKYLINYNVSIISNKIVIEIHDSVIEIESVIFDENNEEELENAYQNINKESSKNNEKAQAILTFLKLMLCCYYKYNLELKQKIPTSFTKWKQNNSHPLILRPLIGHIRHEINVRNMHTIINKIYKKLDPEEFTYEIIEDKYLNLKKTGTIKNPFQKAVEKPLSKFKIILQKLKTKEHLLVELDVTAGDIFVNLVMNLTVSKYANIDDLQLNQQGEFESDCA |
Length | 558 |
Position | Head |
Organism | [Candida] haemulonis |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Metschnikowiaceae> Clavispora> Clavispora/Candida clade.
|
Aromaticity | 0.08 |
Grand average of hydropathy | -0.507 |
Instability index | 52.62 |
Isoelectric point | 5.24 |
Molecular weight | 64466.44 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP20740
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 56.89| 17| 83| 92| 108| 1
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92- 108 (31.03/19.42) KYELLGHIN..FAMNETSL
176- 194 (25.86/15.09) KYQSLNHIKtlFQSAGESL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 153.55| 51| 71| 270| 325| 3
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270- 325 (80.07/61.52) NHKLSIKSNkytrvKILSKFDDDYMLTGQSVFEKSVLED.KSPFRVIN.....DIEKARYFL
343- 399 (73.48/45.79) NYNVSIISN.....KIVIEIHDSVIEIESVIFDENNEEElENAYQNINkesskNNEKAQAIL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 134.79| 45| 459| 3| 54| 4
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3- 54 (63.09/58.88) EPENVTLRFDSNVY......GTAEDPFMQDEEKiPIAELipRILLERQSflniTEEQL
465- 515 (71.71/44.81) DPEEFTYEIIEDKYlnlkktGTIKNPFQKAVEK.PLSKF..KIILQKLK....TKEHL
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