<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20728

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMALSMETQLQSIFEDVVKTEMIEEAFAGMFMDTPEDERTKLISCLGAFRQYWGTLPQESHDQCVQWIVRFIHSQHSPKRISFLYDCLAMAVETSLLPPRMVCVALISSDSLEWERTQLWALTFKLIRKIIGGVDYKYDLMFMDTPEDERTKLISCLGAFRQYWGTLPQESHDQCVQWIVRFIHSQHSPKRISFLYDCLAMAVETSLLPPRMVCVALISSDSLEWERTQLWALTFKLIRKIIGGVDYKGVRDLLKAVLDKIQTIPTTVSSAIVQQLLAAREVVEYILDRNACLLPAYFAITEIRKLYPEGQLSHWLLGSLISDFVDSFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPTTLRFPLRGMLPFDKDLFEPQTGLLRYVLEQPYSREMVCNMLGLNKQHKQRCPVLEEQLVDLVVYAMERSETEEHFDADVGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKECIPVPDINKPQSTHSFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQSLRNKTLGMSDYKIALLCNAYSTNSECFTLPMGVLVETIYGNGSMRINLPGTNCMASGSVTPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSIALAPALVETYSRLLVYMEIESLGIKGFISQLLPNVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHSLAAVPQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLNDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIHGTWCKDILQTIMTFTPHNWASHTLSCFPAPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMANENDIITHFSMQGSPPLFLCLLWKMLLETDHINQIGFRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVNDFVKENAPEHWLQSDWHNKHMSYHKKYPEKLYFEGLADQVNPPMQLQPQYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYERHLRDRTNLKRKLVHAIMSSLKDNRTPGWCLSETYLKCGMNPREDNVWIPDDTYYCKLIGRLVDNILHYSDIEHPLNSVSPMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVPGKEVGNALLNVVLKSQPLVPRENITAWMNAIGLVITALPEPYWIVLHDRIVSVISSPALTSETEWAGYPFALLDFTACHQSYSEMNCSYVLALAHAVWHHSSIGQLSLIPKFLSETLKPVVQTEFQLLYVYHLVGPFLQRFQQERTRCMLEIGVAFYEMLQAVDQHCQHLSYMDPICDFLYHIKYMYTGDSVKEQTPPHKCPAQTPR
Length1458
PositionTail
OrganismScophthalmus maximus (Turbot) (Psetta maxima)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Carangaria> Pleuronectiformes> Pleuronectoidei> Scophthalmidae> Scophthalmus.
Aromaticity0.10
Grand average of hydropathy-0.040
Instability index44.82
Isoelectric point6.74
Molecular weight167259.26
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20728
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     546.15|     108|     108|      29|     136|       1
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   29-  106 (156.17/101.76)	....................................MFMDT.PEDE.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RTKLISCLGA.....FRQYWGTLPQES.....................HDQ...CVQ.WIVRFI....HSQHSPKRISFLYD.CL..AMAVETSLLPPRMVCVALI
  107-  217 (231.14/154.58)	SSDSLE..WERTQLWA.LTFKLIRKIIGGVDYKydlMFMDT.PEDE.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RTKLISCLGA.....FRQYWGTLPQES.....................HDQ...CVQ.WIVRFI....HSQHSPKRISFLYD.CL..AMAVETSLLPPRMVCVALI
  218-  247 (28.97/12.14)	SSDSLE..WERTQLWA.LTFKLIRKIIGGVDYK................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
  737-  805 (53.54/29.45)	..............................................gvrdllkavldkiqtipttvssaivqqllaarevveyildrnacllpayfaiteirklypegqlshwllgslisdfvdsfrptarinsicgrcsllpvvnnsgaicnswkldpttlrfplrgmlpfdkdlfepqtgllryvleqpysremvcnmlglnkqhkqrcpvleeqlvdlvvyamerseteehfdadvggtsqllwqhlssqliffvlfqfasfphmvlslhqklagrglikgrdhlmwvllqfisgsiqknaladflpvmklfdllypekecipvpdinkpqsthsfamtciwihlnrkaqndnsklqipiphslklhheflqqslrnktlgmsdykiallcnaystnsecftlpmgvlvetiygngsmrinlpgtncmasgsvtplpmnlldsltvhakmslihsiatrviklahakssialapalvetysrllvymeieslgikgfisqllpnvfkshawgilhtllemfsyrmhhiqphyRVQLLSHLHS.....L....AAVPQTN.....................QNQlhlCVEsTALRLItalgSSEVQPQFTRFLNDpKT..VLSAESEEL.NR....ALI
  820-  917 (76.33/45.52)	GSDSIHgtWCKDILQTiMTF.....................tPHNW.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ASHTLSCFPAplqafFKQ..NNVPQESrfnlkknveeeyrkwksmaneND.........IITHF....SMQGSPP....LFL.CLlwKMLLET.............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.20|      36|     213|     283|     370|       2
---------------------------------------------------------------------------
  289-  329 (54.04/68.93)	NACL..LPAY.FAITEIRKLYP.....EGQLSHwlLGSLISdFVDsfRP
 1075- 1118 (54.16/ 9.81)	NVCLrfLPVFdIVIHRFLELLPvskslETLLDH..LGGLYK.FHD..RP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.70|      20|     206|    1010|    1031|       3
---------------------------------------------------------------------------
 1010- 1031 (36.18/31.41)	PNDFRN...RVNDFvkENAPEHWLQ
 1217- 1239 (36.52/24.59)	PGPFPNcdwRFNEF..PNPAAHALH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      82.92|      17|     205|     352|     368|       5
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  352-  368 (32.01/18.51)	ICNSWKLDPTTLRFPLR
  564-  580 (28.38/15.52)	IPHSLKLHHEFLQQSLR
  594-  609 (22.53/10.68)	LCNAYSTNSECFTLPM.
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20728 with Med23 domain of Kingdom Metazoa
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