<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20723

Description Putative mediator of RNA polymerase II transcription subunit 25
SequenceMSGDWDEDLCKKALVLVEELCFNSPRGYSQSERCQEFSYMLRGRNRQLDTEISVSLLSVIVTFCGIVLLSVSLFVSWKLCWLPWRDKEGGGLSLTSGLLPGSAGVGSLGGPGGASLLPPLLQRKEGHSSSSLYPTLGQQGQHHPHFSDLVGLERGEVGSVAGGPQETQEHSYLDMDSYPNNAGTLKLSTTSPDVPNSEGGANKDLPNAHSQQQVTPRPKPMTHQLSSPDFHGEEKEQVTSIGQIKPELYRPKGDQGDGKQGDNCGKISFLLRYAFNTEQLVVKILKALDLPAKDANGFSDPYVKIYLLPDRKKKFQTKSPKPLKSTTASLGCTTRRLLCFERRRSFDFNHILINCLSSFVFLAFFPEGSASPAAAAAAAAEKADLGELNFSLCYLPTAGRLTATVIKATNLKAMDLTGFSGQTSEQPRFDLDHDSYGGTQYGLVVFNTVDCAPESYVQCHAPTSSAFEFVSWIDSIQFMGGGAESCSLIAEGLSVALQLFDDFKKMREQIGQTHKVCVLLCNSPPYLLPAVESVSYTGCTADNLVKIIRDKGIHFSVVAPRKLPALRALFERASPVGGVVEPHPDYSQDPFHMVLVRGISLPVSSGGGPGPLKPVLPPQSLPVSQPLVGAPQPPPPINATHPYQNPAPMTAAQVAAQMAVEAANVQKSRFPGMINQGPPFPGQPNIPSVAGVKLSQPSISTVTTASQPMMPQQQVAPNQQQQQPVPPPGQPAPNQQPQQPPQQQQQPTANQPTAPSVQPNMPGVSGPPSGANPVGQAQGVTNKIVAWTGVLEWQEKPKASTMDAATKLTRSLPCQVHVNQGENLNTDQWPQKLIMQLIPQQLLTTLGHLFRNSRMVQFLFTNKDLESLKGLYRIMTNGFAGCVHFPHTTSPCEVRVLMLLYSSKKRIFMGLIPNDQSGFVNGIRQVITSHKQVQQHRAQLGGAVGPMQPGQVPPNQNFLNRAPGPIPVSHGNVQQQMAMRAAGPANQQSSVGGPPPNQVAQGGQAPPQGPILRLSNPGANPQLRSLLLSQQQPQGGVSHMPGIMSHQGLGQQLVHSAPGGGAQMQGQWRQPMPGQVLMSGQRGAGPQPGMPQVSSVMEDEILMDLI
Length1106
PositionUnknown
OrganismScophthalmus maximus (Turbot) (Psetta maxima)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Carangaria> Pleuronectiformes> Pleuronectoidei> Scophthalmidae> Scophthalmus.
Aromaticity0.06
Grand average of hydropathy-0.322
Instability index48.07
Isoelectric point8.54
Molecular weight118876.17
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20723
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.12|      21|      21|     717|     737|       1
---------------------------------------------------------------------------
  714-  736 (39.18/11.44)	QvaPNQQQQQPVPPPGQPAPNQQ
  995- 1015 (29.95/ 6.92)	P..PNQVAQGGQAPPQGPILRLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      27.77|      14|      23|    1030|    1051|       2
---------------------------------------------------------------------------
  674-  690 (16.40/ 7.41)	INQ..G...PPFpgqPNIPSVA
  737-  755 (11.37/ 9.56)	PQQppQqqqQPT...ANQPTAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.27|      21|      23|    1030|    1051|       3
---------------------------------------------------------------------------
  624-  645 (31.75/10.96)	SQPLVGAPQPPPPInaTH..PYQ...N
 1031- 1055 (32.94/15.09)	QQPQGGVSHMPGIM..SHQgLGQqlvH
 1056- 1068 (26.58/ 7.89)	SAPGGG.AQM........Q..GQ...W
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.02|      23|     310|     646|     668|       4
---------------------------------------------------------------------------
  646-  668 (40.34/31.49)	PAPMTAAQVAAQMAVEA...ANVQKS
  965-  990 (37.68/28.80)	PIPVSHGNVQQQMAMRAagpANQQSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.12|      19|      24|     211|     234|       5
---------------------------------------------------------------------------
  207-  228 (29.29/21.72)	NAHSQQQVTP..RPKPmthQLSSP
  231-  251 (27.82/ 7.97)	HGEEKEQVTSigQIKP...ELYRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.87|      18|      19|      90|     107|       6
---------------------------------------------------------------------------
   90-  107 (31.81/19.86)	GGLSLTSGLLPGSAGVGS
  112-  129 (33.06/21.01)	GGASLLPPLLQRKEGHSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.95|      13|      19|     590|     603|       8
---------------------------------------------------------------------------
  590-  603 (21.16/15.53)	PFHMVLVRGiSLPV
  611-  623 (25.78/14.29)	PLKPVLPPQ.SLPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.60|      24|      24|     843|     866|      10
---------------------------------------------------------------------------
  843-  866 (41.37/27.91)	LTTLGHLFRN..SRMVQFLFTNKDLE
  868-  893 (41.23/27.79)	LKGLYRIMTNgfAGCVHFPHTTSPCE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.89|      35|     256|     163|     197|      13
---------------------------------------------------------------------------
  163-  197 (63.47/37.74)	GPQETQEHSYLDMDSYPNNAGTLKLSTTSPDVPNS
  421-  455 (64.42/38.41)	GQTSEQPRFDLDHDSYGGTQYGLVVFNTVDCAPES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.45|      35|     118|     265|     299|      14
---------------------------------------------------------------------------
  265-  299 (59.35/42.42)	GKISFLLRYAFNTEQLVVKILKALDLPAKDANGFS
  386-  420 (61.10/43.89)	GELNFSLCYLPTAGRLTATVIKATNLKAMDLTGFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.81|      11|      37|     910|     921|      15
---------------------------------------------------------------------------
  910-  921 (16.58/12.41)	GLIPNDQSgFVN
  950-  960 (22.23/11.54)	GQVPPNQN.FLN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20723 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGPGPLKPVLPPQSLPVSQPLVGAPQPPPPINATHPYQNPAPMTAAQVAAQMAVEAANVQKSRFPGMINQGPPFPGQPNIPSVAGVKLSQPSISTVTTASQPMMPQQQVAPNQQQQQPVPPPGQPAPNQQPQQPPQQQQQPTANQPTAPSVQPNMPGVSGPPSGANPVGQAQG
2) HPHFSDLVGLERGEVGSVAGGPQETQEHSYLDMDSYPNNAGTLKLSTTSPDVPNSEGGANKDLPNAHSQQQVTPRPKPMTHQLSSPDFHGEEKEQVTSIGQIKPELYRPKGDQGDG
3) QQHRAQLGGAVGPMQPGQVPPNQNFLNRAPGPIPVSHGNVQQQMAMRAAGPANQQSSVGGPPPNQVAQGGQAPPQGPILRLSNPGANPQLRSLLLSQQQPQGGVSHMPGIMSHQGLGQQLVHSAPGGGAQMQGQWRQPMPGQVLMSGQRGAGPQPGMPQVSSVME
607
143
934
779
258
1098










Molecular Recognition Features






MoRF SequenceStartStop




1) YVKIYLL
302
308