<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20719

Description Putative mediator of RNA polymerase II transcription subunit 1
SequenceMGTVSASYCAPQGPCLPSLSPTAVLAAVPTSSSMPGSQLKLLLTQYGSPDGGVVEPKRRTMAAVSGVSVPSGSPARELSTSAQQGGNQTHGDRARTEEVTEVEKQSRMAAVLERLHAKHNASRPWQETCKVVRQAMEKRGTMNAAGHQLLLTCLETLQRALKVSSLPSMTDRLESIARQNMLGSHLSPSGTECYITSDMFYVEVQLDTNGQLVDVKVAHQGENPTSCPELIRHLREKNFEEFSKHLKGLVDLYKLPGDNKLKTKMYIALQSLELDLTKMMHMFRLATNANTVETILHGSVGLLTARSGGHLVTLQCYVSPYDVFEEGIGTQLNLTDNNVPRSLGVGVSVTIEGTSAIYKLPIAPLITGSHPVDNKGTPSFSTVTNSNCVDLPACFFLKMNRPMPFSLSFIQRMGNATSIPVFETSPSLSPLYQLVVQSQLQLLEEGSSTPPPSHNMHFYSVLPDQQHCYFLNGDAPVQDGRSLQGTLVSKIPFRHPAQVPLLLDIIRHQAAYNNLIGSCVKRTSVKEDSAGLLQFEVCPLTDSSFSVSFQHPVNESLVCVVMEVIDSRQVSCKLYKGLSDALICTDEFITKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAQTVEIMVKNNLPPSSSPTYNMAAGDGTNPMGLPGPTGGNTPTGGPPGGPNFTGLFGISRTERQAQAGECINQAGVAGQQQLQQQHQQQQQQQQQGQGHADDYSKVTQNPILTSLLQITGSVGSSPSSQNAPAPHQTPPPTSSPASNTKNHPMLMNLLKDNPTQDFATLYSSSPLERQNSSSGSPRTESMGGACPGSGTKGKKKRPRTGEKGGVLPGTAAGGGVGMKSQQSSSMQQHHPVTHEDDFHRALLSMDVDASQNSIFDVNLTGDGLDTPHSITPAPSQCGTPPPGPGMPYSQSHVQSQQQQPPGTVPPRMVRLSSSDSIGPDITEILSDLPEQTGKSSGGSHGQHLMGSGGEDGGPLGTPIRDSSSSGQGSAVFDSADIFNTNSNENPFTDAADLIAEAAATAATPTSDSSSTNFFPDAADFNPDLLTPGHGFSQNYFDDSSPSADGDMDLVKGFGGSSQQNTPAGTPQNPTPHGQSTPEPSMKDPFDMGIVFGGNSGGGKPLLGQAPDLGDTHGTGSQSPLMIGLAAACGEFKSAEPKIKQQQGLMRPKDENGGSGGSSSGMGMGSSSTEGKQVKRSRTPSSEGKSKEKPPKRKKLDPDGKSPSHSSGGRPYTPPSGGSGSGGSISGGGSKSPGSSGRSQTPPGGATPLKITIQIPKGTITGGKTSSHSGYTSSSSGTSSTGGTGATGISKSHHSHSSSSGKMKSKEASMTQGNSSKPGSAGVGGGGGPTQSKGSSQGLGVGKPGSSPITKHGLSGPGGNAGGIGSANKVKPPGGKPSGSLMNPNIKPNISPSHSRSSSSGDKLSSPMKMQQSQVPGTPPSSKAKSPMGSGGGSSGGSKSSGGGMSSQKPMGGSSSSGSASSSSSSGSSSSGSMTFSGGSQSQYASGGGGSGGAGGGSGGSGGGGGSGSGGGGGSSGGAGQNNANNPNAKGKSPSRNKKPSLTAVIDKLKSVGGGGVGEDGCEVGPPAGGTGSGSAPGGGPGNVPSSGPSSMGPSKHASSSQSGEYKREKSDKEAKVKVSVSGGNSGDKKQMDPKSGGAGTTGLAKIIISKPDGGSPSIKAKGNLQKAGEGSGDSMRPQISSLKASPLFSGSTPKHDRSSPSHSRSPGYTPLNHDSESESGSSSVAEKSHQNSPSSDDDQTMRPHPPQDYMSSIPLSSGEKHKKHKKEKKKQKERERERDRDRERDRDKEKKKSSMSMGPSSHPIKADSWSRSPISASDSSLSMLGSERPSRPSPMYMRNEDDDLMDSALTGNL
Length1884
PositionMiddle
OrganismScophthalmus maximus (Turbot) (Psetta maxima)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Carangaria> Pleuronectiformes> Pleuronectoidei> Scophthalmidae> Scophthalmus.
Aromaticity0.03
Grand average of hydropathy-0.649
Instability index57.02
Isoelectric point8.92
Molecular weight194042.94
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20719
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     491.99|      60|      60|    1206|    1265|       3
---------------------------------------------------------------------------
  793-  854 (58.42/11.39)	YSSSPLERQNSSSG....S..........PRTESM..G.....G.A...CPGS....GTK.......GkkkR............PRTGE...KGG.V....LPGTAAGGGvGMKS.Q...QS
 1096- 1155 (60.80/12.23)	TPQNPTPHGQSTPE....P..........SMKDPFDMG.....I.V...FGGN....SGG.......G...K............PLL......GQ.A....PDLGDTHGT.GSQS.PlmiGL
 1163- 1202 (46.31/ 7.15)	K....SAE.....................PKIKQ..QQ.....GlM...RPKD....ENG.......G........................SGG.S....SSG..MGMG.SSST.E...GK
 1206- 1265 (116.30/31.68)	RSRTPSSEGKSKEK....P..........PKRKKLDPD.....G.K...SPSH....SSG.......G...R............PYTPP...SGG.S....GSGGSISGG.GSKS.P...GS
 1268- 1325 (58.29/11.35)	RSQTPPG.GATPLKitiqI..........PKGTI..TG.....G.K...TSSH.....S........G.................YTSS...SSGtS....STGGTGATG.ISKS.H...HS
 1326- 1396 (44.64/ 6.56)	...HSSSSGKMKSK....EasmtqgnsskPGSAGVGGG.....G.....GPTQ....SKGssqglgvG...K............PGSSPitkHGL.S....GPGGN.AGG......I...GS
 1399- 1472 (51.21/ 8.87)	KVKPPG..GK...................PSGSLMNPN.....I.KpniSPSHsrssSSG.......D...KlsspmkmqqsqvPGTPP...SSK.AkspmGSGGG.SSG.GSKS.S...G.
 1553- 1617 (56.02/10.55)	NANNPNAKGKS.......P..........SRNKK..PSltaviD.K...LKSV....GGG..gvgedG...C............EVGPP...AGG.T....GS.GSAPGG.GPGNvP...SS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      84.88|      19|      19|    1826|    1844|       8
---------------------------------------------------------------------------
 1478- 1496 (27.00/ 9.13)	QKPMGGSSSSGSASSSSSS
 1619- 1633 (23.25/ 6.59)	PSSMGPSKH...ASSSQS.
 1825- 1843 (34.63/14.28)	SMSMGPSSHPIKADSWSRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.37|      19|      20|    1028|    1047|       9
---------------------------------------------------------------------------
 1005- 1020 (28.09/13.59)	SADIFN...T....NSNENPFTD
 1028- 1047 (29.67/19.58)	AAATAA...TPtSDSSSTNFFPD
 1048- 1069 (31.61/16.44)	AADFNPdllTP.GHGFSQNYFDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.80|      18|      19|    1790|    1807|      10
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 1757- 1775 (24.89/12.33)	EKsHQNSPSSDDDQTMRPH
 1790- 1807 (28.91/15.65)	EK.HKKHKKEKKKQKERER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.44|      21|      67|     856|     877|      11
---------------------------------------------------------------------------
  856-  877 (36.79/24.14)	SMQQHHPVTHEDDFHRaLLSMD
  926-  946 (39.65/21.83)	SQQQQPPGTVPPRMVR.LSSSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.74|      18|      25|     374|     392|      12
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  375-  392 (32.64/13.57)	KGTP.SFSTVTN.SNCVDLP
  401-  420 (22.10/10.30)	RPMPfSLSFIQRmGNATSIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.56|      19|      22|     677|     698|      13
---------------------------------------------------------------------------
  677-  698 (26.16/23.34)	GLFGISRTERQAQAGEcinQAG
  701-  719 (34.40/20.30)	GQQQLQQQHQQQQQQQ...QQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     177.70|      52|     277|     179|     233|      14
---------------------------------------------------------------------------
  179-  233 (85.42/57.73)	QNMLGSHLSPSGTECYITSDMFYVEVQLDTNGQLVDvKVAHQgeNPTSCP...ELIRH
  454-  508 (92.28/52.70)	HNMHFYSVLPDQQHCYFLNGDAPVQDGRSLQGTLVS.KIPFR..HPAQVPlllDIIRH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.55|      18|     118|    1531|    1550|      15
---------------------------------------------------------------------------
 1532- 1550 (31.90/ 9.28)	GGGgGSGSGGG.GGSSGGAG
 1652- 1670 (28.64/ 7.20)	SGG.NSGDKKQmDPKSGGAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.83|      36|     174|     333|     374|      17
---------------------------------------------------------------------------
  333-  374 (53.21/48.23)	NLTDNNVPRSlgvgvSVTiEGTSAIYKLPIAPLITGS......HPVDN
  514-  555 (57.62/35.52)	NLIGSCVKRT.....SVK.EDSAGLLQFEVCPLTDSSfsvsfqHPVNE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20719 with Med1 domain of Kingdom Metazoa
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