<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20718

Description Mediator of RNA polymerase II transcription subunit 24
SequenceMKVVNLKQAILQAWKERWSDYQWAINIKKNFPKGATWDYLNLAEALMEQAMIGPSPNPLILSYLKYAISSQMVSYSSVLNAISKFEDFSRELCVKSLLEIMDMFCHRLSCHGKAEECIGLCRALLGVVVWLLQGCAWYCESLRELGPSASTEASLRACQERLHSLLNNTKNRALVHIARLEEQGSWSNVEQAMLKVTDGLGCVPNQTMRSKLEESLSLVKGIPLMLSVQSEPQLHPSFPSVHAFIMLEGTMNLTGETQPLVEQLMMIKRMQQIPAPLFVLEIWKACFTGLIESPEGTEELKWTAFTFLKIPQVLLRLKKYPQGDKGQDFMDDVNIAFQYLLKLTPLLDKADQRCNCDCLGMLLQECNKLGLLSDSNTTSLTSKREFAPRLKTAENANIQPNPGLILRAEPTVTNILKTVDADHSKSPEGLLGVLGHMLSGKSLDLLLAAAAATGKLKSFARKFIKLNEFPKHISGEGSKSASVRALLFDISFLMLCHVVQTYGSEVILSDPSPSGETPFFETWLQTCMPEEGKTLNPDHPCFRPEPGKVESLVTLLNNSSEMKLVQVKWHEICLSTPAAILEVLNAWENGVLSVEAVQKITDNIKGKVCSMAICAVAWLVAHVRMLGRDEREKPQTMIRQLVTPLYGENTLQFYNERVIIMSSIMEHMCADVFQQTAAALRPPMEGLEPIPYRNLLPAKEPIHAALSKQFQAVLRKGWADSRALHLFESLLNMGGVFWFTNNLVKELLKETRQEWATRVVELLYSIFCLDTQQITLTLLGTILPDLLTDSAHWHSLADPPGKALAKLSVWCALSSYSSHHRGSFSARQRKRQREDIEDYNSLFPLDDTQPSKLMRLLSSNEDEPVALSSPGDRSMSSSLSASQLHTVNMRDPLNRVLANLFLLISSIVGSKMAGPHTQFVQSFMEECVECLEQGSRGSILQFMPFTMVSELVKLPALAKPRVVLAITDLTLPLGRRVAAKAISAL
Length985
PositionTail
OrganismScophthalmus maximus (Turbot) (Psetta maxima)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Carangaria> Pleuronectiformes> Pleuronectoidei> Scophthalmidae> Scophthalmus.
Aromaticity0.07
Grand average of hydropathy-0.031
Instability index44.84
Isoelectric point6.76
Molecular weight109941.71
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
enteric nervous system development	GO:0048484	IEA:Ensembl
interstitial cell of Cajal differentiation	GO:0061453	IEA:Ensembl
retinal cone cell development	GO:0046549	IEA:Ensembl
thymus development	GO:0048538	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20718
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.37|      26|     113|     417|     442|       1
---------------------------------------------------------------------------
  417-  442 (43.99/24.96)	KTVDADHSK.SPE.GLLGVLGHMLSGKS
  533-  560 (37.38/20.14)	KTLNPDHPCfRPEpGKVESLVTLLNNSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     142.72|      35|      35|     695|     729|       2
---------------------------------------------------------------------------
  666-  699 (54.75/32.34)	EH..MCADVFQQTAAALRPPMEGLEPIP.YRNLLPAK
  700-  734 (57.03/33.99)	EP..IHAALSKQFQAVLRKGWADSRALHLFESLLNMG
  735-  765 (30.94/15.09)	GVfwFTNNLVKELLKETRQEWA.TRVVELLYS.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.88|      28|      35|     142|     169|       3
---------------------------------------------------------------------------
  142-  169 (45.82/26.84)	LRELGPSASTEASLRACQERLHSLLNNT
  180-  207 (49.06/29.22)	LEEQGSWSNVEQAMLKVTDGLGCVPNQT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.48|      28|     388|      89|     118|       5
---------------------------------------------------------------------------
   89-  118 (49.65/31.86)	SRELCVKSLL.EI.MDMFCHRLSCHGKaeECI
  478-  507 (39.82/20.11)	SKSASVRALLfDIsFLMLCHVVQTYGS..EVI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.77|      26|     639|     210|     265|       6
---------------------------------------------------------------------------
  210-  235 (44.68/66.65)	SKLEESLSLVKGIPLMLSVQ.........SEPQLH
  851-  885 (37.08/ 7.68)	SKLMRLLSSNEDEPVALSSPgdrsmssslSASQLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.82|      11|      30|     304|     314|       7
---------------------------------------------------------------------------
  304-  314 (19.61/12.29)	AFTF.LKIPQVL
  336-  347 (15.21/ 7.82)	AFQYlLKLTPLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20718 with Med24 domain of Kingdom Metazoa
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