<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20718

Description Mediator of RNA polymerase II transcription subunit 24
SequenceMKVVNLKQAILQAWKERWSDYQWAINIKKNFPKGATWDYLNLAEALMEQAMIGPSPNPLILSYLKYAISSQMVSYSSVLNAISKFEDFSRELCVKSLLEIMDMFCHRLSCHGKAEECIGLCRALLGVVVWLLQGCAWYCESLRELGPSASTEASLRACQERLHSLLNNTKNRALVHIARLEEQGSWSNVEQAMLKVTDGLGCVPNQTMRSKLEESLSLVKGIPLMLSVQSEPQLHPSFPSVHAFIMLEGTMNLTGETQPLVEQLMMIKRMQQIPAPLFVLEIWKACFTGLIESPEGTEELKWTAFTFLKIPQVLLRLKKYPQGDKGQDFMDDVNIAFQYLLKLTPLLDKADQRCNCDCLGMLLQECNKLGLLSDSNTTSLTSKREFAPRLKTAENANIQPNPGLILRAEPTVTNILKTVDADHSKSPEGLLGVLGHMLSGKSLDLLLAAAAATGKLKSFARKFIKLNEFPKHISGEGSKSASVRALLFDISFLMLCHVVQTYGSEVILSDPSPSGETPFFETWLQTCMPEEGKTLNPDHPCFRPEPGKVESLVTLLNNSSEMKLVQVKWHEICLSTPAAILEVLNAWENGVLSVEAVQKITDNIKGKVCSMAICAVAWLVAHVRMLGRDEREKPQTMIRQLVTPLYGENTLQFYNERVIIMSSIMEHMCADVFQQTAAALRPPMEGLEPIPYRNLLPAKEPIHAALSKQFQAVLRKGWADSRALHLFESLLNMGGVFWFTNNLVKELLKETRQEWATRVVELLYSIFCLDTQQITLTLLGTILPDLLTDSAHWHSLADPPGKALAKLSVWCALSSYSSHHRGSFSARQRKRQREDIEDYNSLFPLDDTQPSKLMRLLSSNEDEPVALSSPGDRSMSSSLSASQLHTVNMRDPLNRVLANLFLLISSIVGSKMAGPHTQFVQSFMEECVECLEQGSRGSILQFMPFTMVSELVKLPALAKPRVVLAITDLTLPLGRRVAAKAISAL
Length985
PositionTail
OrganismScophthalmus maximus (Turbot) (Psetta maxima)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Carangaria> Pleuronectiformes> Pleuronectoidei> Scophthalmidae> Scophthalmus.
Aromaticity0.07
Grand average of hydropathy-0.031
Instability index44.84
Isoelectric point6.76
Molecular weight109941.71
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
enteric nervous system development	GO:0048484	IEA:Ensembl
interstitial cell of Cajal differentiation	GO:0061453	IEA:Ensembl
retinal cone cell development	GO:0046549	IEA:Ensembl
thymus development	GO:0048538	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20718
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.37|      26|     113|     417|     442|       1
---------------------------------------------------------------------------
  417-  442 (43.99/24.96)	KTVDADHSK.SPE.GLLGVLGHMLSGKS
  533-  560 (37.38/20.14)	KTLNPDHPCfRPEpGKVESLVTLLNNSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     142.72|      35|      35|     695|     729|       2
---------------------------------------------------------------------------
  666-  699 (54.75/32.34)	EH..MCADVFQQTAAALRPPMEGLEPIP.YRNLLPAK
  700-  734 (57.03/33.99)	EP..IHAALSKQFQAVLRKGWADSRALHLFESLLNMG
  735-  765 (30.94/15.09)	GVfwFTNNLVKELLKETRQEWA.TRVVELLYS.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.88|      28|      35|     142|     169|       3
---------------------------------------------------------------------------
  142-  169 (45.82/26.84)	LRELGPSASTEASLRACQERLHSLLNNT
  180-  207 (49.06/29.22)	LEEQGSWSNVEQAMLKVTDGLGCVPNQT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.48|      28|     388|      89|     118|       5
---------------------------------------------------------------------------
   89-  118 (49.65/31.86)	SRELCVKSLL.EI.MDMFCHRLSCHGKaeECI
  478-  507 (39.82/20.11)	SKSASVRALLfDIsFLMLCHVVQTYGS..EVI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.77|      26|     639|     210|     265|       6
---------------------------------------------------------------------------
  210-  235 (44.68/66.65)	SKLEESLSLVKGIPLMLSVQ.........SEPQLH
  851-  885 (37.08/ 7.68)	SKLMRLLSSNEDEPVALSSPgdrsmssslSASQLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.82|      11|      30|     304|     314|       7
---------------------------------------------------------------------------
  304-  314 (19.61/12.29)	AFTF.LKIPQVL
  336-  347 (15.21/ 7.82)	AFQYlLKLTPLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20718 with Med24 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




NANANA