<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20715

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMPNFAIGNINTYGPAELTGIKWRCYNFRGGGEYGPVISAPAQDDPVLRSFMRCVQANLLCVWRRKIKPDAKELWIFWWGEEPNLADVIHHELEVAEEGLWECGLSYECRTLLFKAIHNLLERCLMDKGFVRIGRWFFKPHDLEEKSLGNSEHLSCSFSFFLHGESNVCTSVEIAQHQPAYHITEHHIRLAQTSITPVQVILSPYGLSGTLTGQAYKMSDPAVRKLMEDWSYFYPMVLQQKEGSGEKEKEEASQACDRNGHVAVEVIVGGVRMTYPAAFVLIAQGDLPLEQPPPVPAAQGLNREPNHCGVPLTPPTSPEQPCSADSGFVTSVSSVPTLDSSMGVTSISPKHSGKKLTCQVVHQAWRECYLSQPQPVLNPPSDVTPKKEVPNGVTTWDFNDLGARASCSCSRVRQQKLNLTTTSSANAQTSANPTQSSGPSLYPPSLPKHKTSEKTEKADKLSKRPAMVPFHHRLSVTQDTPLEQDSPGGPQLGGLVAMEPPMEPLAALPSCKYPKALSRKGESLLHSPMSPLPPTLSPHPRVQDPEVLDGPMDMAICPDGVSGLGPISSETAVYTALLRQRENGAGWWRGFRTPRTDKTDVRPPELPTDKLEEVKAEAATEGAPLKRLYTQTHKRFKISEERVKDHIHTLGLFQQPGVEALREPGDDPYDFKEGDIEYTFSTSKRLKGQGREPSKKAKGEEITSNGALPDGKDAMSIFNSAPKSDESGQDDGAAKANPSLTREKDLVVNISDLDNIFDEDEEELGTVYPNQHSAKVPVSTEDRPLGKEGRVAVPYPSTVADLQRMFPTPPSLEQHPAFSPIMTYRDTPSQEPPAPSAAADHLPPLASTQLMEYRMETDESMASPRQEDIKPQIGSSMFAPLSCLPSQSLPPLKIPEQCYYRPSWSLMPKMEHFPAVMHPQSNAFIRDGYTNVPSVNAFTDQEYSQMSAATPSVGTTVGILPSPATPRFSVPTPRTPRTPRGINAASSGQGSVKQDGTELSSPASTPSTSMPLSSVEPHARPGPSLPEAHSLYAILLLSDSVLNVFKDRNFDSCCICACNLNVKGADVGVYIPDSTCEDQYRCMCGFSAIVNRRLAHGTGLFLEDELDIYGRTSEVGRAAERRLALCRRDPTMGNPKAKRPQDAAPASPSVMVLLQEQCAQPISSLTSLHLPLSCSCHGRKGALLQSWMSEKQWADGSDACVECYNALEQGLQYVDNPTGGKVDPAVVRSTALHSWPHTNVVEMSMLSSQDMVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGSYGSEESPEPLPIPTVLLGYDRERDFLALSPLALPFWEKLLLEPYGGQRDVAYVVLCPNSPSLLAAARVFFQELSAVYETCRLGKHRPLGKVSRDGLVRVGEDVEPEKLEELDVDQWMTGPWAGQQHTDNLSKLKLYAYACKQQLGPQLSALPLDSSLLLPPKAQPPVNNTPSAQPASTGQTQAWAPDGEQAQGAVSSANAPTPTGATSGQTGETSQGGTSESKGTSSATPPANTPAEIPELTSEQSRIGIPTVADSMDGLANPPAVVIYIVDAFLGSSAARSEGGEEEEGDEVEAGSIWLLGLLRCYTEMLQTLPEMMRPALVLQVVPCQYLLQPASGESRLYLQHLRSMAFSCYSQCRRLLPQQTHIKSLTGFGPVSIVNSVLKGPEHPNPLQLYTPPFILGPTRPKQPEQGEIWAEIPPRYNVLYVGYCLSHDQRWILVSCTDQQGELLESCIINIDVPNRARRPKVSARKMGLQKLWEWCIGIIQMTSLPWRIVIGRLGRLGHGELKDWSSLLGEHSLHSIGRQLREACRICGISAVDSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNLQTSQLNTPQDASCTHILVFPTSATTQLAPSSYPTEDNNDDMFDLPFPDELENDIGHDMMLITGNLHPSPNTSPVPSPGSPSGMGMGSNFHHTRSQGERLLSRDNPPEELKQQPLALGYYVSTAQTNGLPHWFWASCPQAESQCPLFLKASLHHHISIAQSDELVSDKTKRTPHPLDSKTTSDVLR
Length2062
PositionMiddle
OrganismScophthalmus maximus (Turbot) (Psetta maxima)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Carangaria> Pleuronectiformes> Pleuronectoidei> Scophthalmidae> Scophthalmus.
Aromaticity0.06
Grand average of hydropathy-0.412
Instability index57.53
Isoelectric point5.66
Molecular weight225691.00
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20715
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.65|      22|      24|     877|     900|       1
---------------------------------------------------------------------------
  832-  853 (39.65/12.34)	PAPSAAADHLPPLASTQLMEYR
  879-  900 (43.01/17.64)	PLSCLPSQSLPPLKIPEQCYYR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     352.01|     114|     213|     287|     404|       2
---------------------------------------------------------------------------
  287-  341 (72.63/25.19)	...........................................................................PLEQPPPVPAAQGLNREPN...HCGV..P.LTPPTSPEQPCSADSGFVTSVSSVPTLDSSM
  342-  466 (155.66/72.54)	GVTSISPKHSGKKLTCQVVHQawRECYLSQPQPVLNPPSDVTPKKevPNGVTTWDFNDLGARAscscsrvrqqklNLTTTSSANAQTSAN..PT...QSSG..PsLYPPSLPKHKTSEKTEKADKLSKRPAM....
  503-  555 (47.95/13.80)	...........................................................................PLAALPSCKYPKALSRKGEsllHSP.msP.LPPTLSP.HPRVQD....PEVLDGP.MDMAI
  559-  617 (75.77/27.38)	GVSGLGPISSETAVYTALLRQ..RENGAGWWRGFRTPRTDKTDVR..PPELPTDKLEEVKAEA.........................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.73|      24|      24|    1849|    1872|       3
---------------------------------------------------------------------------
 1849- 1872 (44.68/24.98)	AMEPQGSFVVMP.DA.VTMGSVFGRS
 1874- 1899 (35.05/18.00)	ALNLQTSQLNTPqDAsCTHILVFPTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.60|      22|      24|    1304|    1327|       4
---------------------------------------------------------------------------
 1306- 1327 (40.92/25.29)	PLPIPTVLL..GYDRERD..FLALSP
 1329- 1354 (34.68/14.03)	ALPFWEKLLlePYGGQRDvaYVVLCP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.06|      27|      28|    1458|    1485|       5
---------------------------------------------------------------------------
 1459- 1485 (51.60/31.72)	KAQPPVN..NTPSAQPASTGQTQAWAPDG
 1487- 1515 (43.45/20.32)	QAQGAVSsaNAPTPTGATSGQTGETSQGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.59|      28|      28|    1769|    1796|       6
---------------------------------------------------------------------------
 1751- 1779 (47.29/32.30)	CIINIDVPNRARRpKVSAR..KMGLQKLWEW
 1780- 1809 (48.30/33.17)	CIGIIQMTSLPWR.IVIGRlgRLGHGELKDW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.10|      23|      28|    1055|    1079|       7
---------------------------------------------------------------------------
 1055- 1079 (39.17/34.63)	CACN....LNVKGA.DVGVYIPDSTceDQY
 1081- 1108 (32.93/20.38)	CMCGfsaiVNRRLAhGTGLFLEDEL..DIY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.49|      19|      22|    1676|    1696|       9
---------------------------------------------------------------------------
 1676- 1696 (31.25/22.79)	IVNSVlkGPEHPNPLQLYT..PP
 1698- 1718 (32.24/17.13)	ILGPT..RPKQPEQGEIWAeiPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.72|      18|      22|     957|     978|      10
---------------------------------------------------------------------------
  957-  975 (29.18/10.93)	GIlPSPATPRFSVPTPRTP
  980-  997 (27.54/10.66)	GI.NAASSGQGSVKQDGTE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.15|      31|     213|     907|     944|      11
---------------------------------------------------------------------------
  907-  944 (47.89/51.24)	PKMEHfPAVMHPQsnafirDGYTNVPSVNAFTDQEYSQ
 1129- 1159 (56.26/38.04)	PTMGN.PKAKRPQ......DAAPASPSVMVLLQEQCAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.29|      18|      24|     660|     678|      13
---------------------------------------------------------------------------
  660-  678 (29.70/19.84)	LREPGDDPYDFKEGDiEYT
  685-  702 (30.59/15.91)	LKGQGREPSKKAKGE.EIT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.71|      20|     284|     737|     758|      15
---------------------------------------------------------------------------
  737-  756 (33.00/27.05)	PSLTREKDLVV....NISDLDNIF
  782-  805 (27.70/13.46)	RPLGKEGRVAVpypsTVADLQRMF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.27|      13|      24|    1404|    1417|      24
---------------------------------------------------------------------------
 1404- 1417 (20.61/16.49)	KLEELDVDQWMtGP
 1431- 1443 (24.66/14.62)	KLYAYACKQQL.GP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20715 with Med13 domain of Kingdom Metazoa
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